Bulbous buttercup.
Research-backed compound with potential health benefits. Poisons you. It causes severe irritation to all mucous membranes, leading to oral blistering, abdominal pain, and potential internal bleeding. It's a toxin, not a therapy.
Reviewed March 2026
- Category
- Compound
What Bulbous buttercup is, and what it does.
- Does it work
- No. This is dangerous. Historically used to create blisters on purpose. Modern medicine has safer ways to do... Well, anything. Do not ingest this.
- How much to take
- Zero. The correct dose is none. The toxic dose is very small. Do not consume any amount of this plant.
- Time to feel it
- The fresh plant's irritant acts on contact within minutes. There is no supplement timeline here, because no intake amount has been established for it in people.
- The first dose
- Immediate and painful blistering in the mouth and throat. Then comes the nausea, vomiting, and dizziness. This is a rapid-onset poison.
- With regular use
- If you survive the acute poisoning, you could face kidney damage or nervous system issues. This is not for 'long term' anything.
- How well tolerated
- Not safe. It's a known toxin. Skin contact causes rashes and blisters. Ingestion is a medical emergency.
- How it feels
- Like you've been poisoned, because you have. Burning pain, severe cramps, and violent GI distress. Not a supplement 'feel'.
- The overlooked benefit
- Drying changes the chemistry. The irritant in the fresh plant breaks down as the material dries, which is why cured hay is not the same substance as a freshly crushed stem.
100 to 250mg a day is where Bulbous buttercup works.
Source: Homeopathic/traditional use references only; Ranunculus bulbosus
The proof, claim by claim.
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
Bulbous buttercup is documented in the library; the clinical read is in the queue. Nothing about the strength of the research prints until the read is done.
- Release of protoanemonin when the fresh plant is crushedIn vitro study
- Irritation of skin and mucous membranes from contact with the fresh plantNarrative review
- Loss of the irritant as the plant material driesNarrative review
- Historical topical folk use of the fresh plant as a blistering agentNarrative review
Questions people ask about Bulbous buttercup.
- Is this safe to eat?
- Absolutely not. It's a toxic plant. Eating it can land you in the hospital.
- What about in a very small dose?
- There is no safe dose. The active toxin is damaging even in tiny amounts. That's not how biology works.
- Can I touch it?
- Best not to. It can cause contact dermatitis and blistering, especially if the plant stem or leaves are crushed.
- Are there any real health benefits?
- No. Its archaic use in folk medicine was to intentionally cause blistering. Modern medicine has far safer and more effective options for everything.
- What if I or my pet accidentally eats some?
- Call poison control or seek emergency medical attention immediately. Do not wait for symptoms to appear.
No pairing data for Bulbous buttercup yet.
Nothing on file for Bulbous buttercup, either from a combination trial or from settled biochemistry. When either lands, it appears here with its source.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
21 pairings are live across the library today. Checked 9 August 2026.
Nothing specific on file for Bulbous buttercup. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.