Supplement Interactions Checker
Check 59,000+ supplement-drug and supplement-supplement interactions for free. Powered by SUPP.AI data from the Allen Institute for AI, covering interactions extracted from biomedical research literature. Enter your supplements below or use our Stack Analyzer to check your entire supplement regimen at once.
Check Multiple Supplements at Once
Our stack analyzer checks all your supplements for interactions in seconds.
Analyze My StackMost Important Interactions
Magnesium + Blood Thinners
ModerateWhat to know about magnesium and anticoagulants
Learn moreFish Oil + Blood Thinners
ModerateOmega-3s and anticoagulant safety
Learn moreVitamin K + Warfarin
SignificantCritical interaction for warfarin users
Learn moreSt. John's Wort + Birth Control
SignificantWhy this combination is dangerous
Learn moreMagnesium + Antibiotics
SignificantTiming matters for antibiotic effectiveness
Learn moreGrapefruit + Statins
SignificantWhy grapefruit affects cholesterol meds
Learn moreSupplement + Supplement
Interactions by Medication Type
💉Blood Thinners
❤️Blood Pressure Medications
🦋Thyroid Medications
🩸Diabetes Medications
Our Interaction Data
59,000+
Documented interactions
Clinical
Evidence-based data
Updated
Regular literature review
Frequently Asked Questions
How do I check supplement interactions?
Use our free supplement interactions checker above. Search for any supplement or medication to see known interactions. You can also use the Stack Analyzer to check your entire supplement regimen at once for conflicts, timing issues, and absorption problems.
Can supplements interact with medications?
Yes. Many supplements interact with prescription medications. Common examples: St. John's Wort reduces birth control effectiveness, fish oil increases blood thinner effects, and calcium blocks thyroid medication absorption. Always check interactions before combining supplements with any prescription drug.
What are the most dangerous supplement interactions?
The highest-risk interactions involve blood thinners (warfarin + vitamin K, fish oil + anticoagulants), thyroid medications (calcium and iron blocking absorption), and birth control (St. John's Wort reducing effectiveness). These can cause serious medical consequences if not managed with your doctor.
Where does IngredientMD get its interaction data?
Our interaction data comes from SUPP.AI, a research dataset created by the Allen Institute for AI. It contains 59,000+ supplement interactions extracted from biomedical literature using machine learning, cross-referenced with clinical trial data and pharmacological research.