For For everyone, adults. Melatonin is the lead active here, studied most for body clock alignment. 18 human studies on Melatonin back this formula, each one cited. Each serving carries 3 mg of Melatonin, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 7 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 47,000+ clinical trials and 59,000+ interaction records. No individual reviewer is named or implied.
Cross-checked against 640 documented interactions for these actives.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.
About 7 minutes shorter time to fall asleep, on average across the trials.
Read at the source. The magnitude sits beside the same trial the claim already cites. It describes what the trials measured, never what any one person will feel.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a crossover pharmacokinetic study, 12 healthy male volunteers received 10 mg of oral melatonin and 10 mg intravenously on separate days. Oral melatonin reached mean peak plasma concentration 40.8 minutes after ingestion, with a mean elimination half-life of 53.7 minutes and absolute bioavailability of about 3 percent. A separate randomised double-blind crossover trial in 18 healthy adults aged 18 to 65 measured time to peak concentration of 0.6 hours for 4 mg immediate-release melatonin and 1.56 hours for a 4 mg extended-release form. Both studies measured blood concentration, not sleep. The second was run by employees of Pharmavite, a supplement manufacturer.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 48% of Americans
take in less magnesium than recommended from food and drink.
NIH Office of Dietary Supplements30.5% of US adults
slept less than 7 hours on average in a 24-hour period in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202654.8% of US adults
woke up feeling well-rested every day or most days in the past 30 days in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202615.4% of US adults
had trouble falling asleep, and 18.1% trouble staying asleep, every day or most days in the past 30 days in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202612.9% of US adults
used a sleep aid most days or every day in the past 30 days to help them fall or stay asleep in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202642% of US adults
say they get as much sleep as they need, the first time since Gallup began asking in 2001 that fewer than half did, in a December 2023 poll.
Gallup, 202463% of US adults who want more sleep
say they frequently experience stress, against 31% of those who get the sleep they need, in a December 2023 Gallup poll.
Gallup, 202474% of US adults
report their sleep is sometimes, often or always disrupted by stress, in a 2024 survey commissioned by the American Academy of Sleep Medicine.
American Academy of Sleep Medicine, 20242.1% of US adults
reported using melatonin in 2017 to 2018, up from 0.4% in 1999 to 2000, across ten cycles of the National Health and Nutrition Examination Survey.
JAMA, 202259 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
of adults refilling a daily long-term medicine on their own had stopped within a year, against 33% to 44% of those whose refills were scheduled to one recurring pickup day, in a matched pharmacy cohort.
Cohort study, 201557.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health StatisticsAbout 7 minutes shorter time to fall asleep, on average across the trials
About 7 minutes shorter time to fall asleep on average across trials, in adults and children with disrupted sleep, ranging from about 4.4 to 9.8 minutes.
Meta-analysisMeta-analysis, 2013
About 7 minutes shorter time to fall asleep on average across trials, in adults and children with disrupted sleep, ranging from about 4.4 to 9.8 minutes.
PLoS OneMeta-analysis, 2024
Across 26 randomized trials, melatonin's shortening of time to fall asleep and lengthening of total sleep time both peaked near a 4 mg dose taken about 3 hours before the target bedtime.
Journal of Pineal ResearchSystematic review, 2025
Among botanicals reviewed for psychological wellbeing in older women, valerian was one of the more studied options, with the included trials reporting modest improvement in self-reported mood and sleep measures.
Frontiers in pharmacologyReview, 2026
Reviewing the human and mechanistic work on Valeriana species and sleep, the authors describe small improvements in self-reported sleep quality alongside GABAergic mechanisms, while noting the clinical trials are small and varied.
Pharmaceutical biologyRandomised trial, 2011
Drinking passionflower tea for a week raised subjective sleep-quality ratings compared with placebo (p < 0.01) in 41 healthy adults.
Phytotherapy ResearchRandomised trial, 2024
In a double-blind placebo-controlled trial, a Melissa officinalis phytosome improved self-reported sleep quality scores in adults reporting poor sleep.
NutrientsMeta-analysis, 2025
Across cardiometabolic outcomes, melatonin was linked to small reductions in blood pressure and in blood lipid levels.
Meta-analysisMeta-analysis, 2016
Across 34 trials in 2,028 adults, magnesium at about 368 mg daily for three months lowered systolic pressure by about 2.0 mmHg and diastolic by about 1.8 mmHg versus placebo.
The paperMeta-analysis, 2025
Across 38 trials in 2,709 adults, magnesium lowered systolic pressure by roughly 2.8 mmHg and diastolic by 2.1 mmHg, with bigger effects in those with high readings or low magnesium.
The paperMeta-analysis, 2025
Across 23 trials in 1,345 adults with elevated blood sugar, magnesium raised blood magnesium, lowered fasting blood sugar by about 0.58 mmol/L, and only slightly moved longer-term blood sugar control.
Sultan Qaboos University Medical JournalRandomised trial, 2003
In 46 healthy adults, magnesium citrate raised serum magnesium more than magnesium oxide or amino-acid chelate after both a single dose and 60 days of daily use, indicating higher absorption of the citrate form.
Magnesium ResearchRandomised trial, 2014
In 862 adults preparing for colonoscopy, a split-dose sodium picosulfate plus magnesium citrate regimen produced adequate bowel cleansing in 85.8% of people compared with 69.8% on the standard dosing schedule.
EndoscopySystematic review, 2020
Across nine clinical trials, passionflower preparations most often lowered anxiety ratings, with the effect weaker in people whose anxiety was already mild and no memory or psychomotor decline reported.
NutrientsRandomised trial, 2001
In 36 adults with ongoing anxiety, a passionflower extract eased anxiety ratings about as much as oxazepam over four weeks, with fewer reports of daytime job-performance impairment.
Journal of Clinical Pharmacy and TherapeuticsRandomised trial, 2008
A single 500 mg dose of passionflower given 90 minutes before ambulatory surgery lowered pre-procedure anxiety ratings versus placebo (p < 0.001) without adding sedation.
Anesthesia and AnalgesiaRandomised trial, 2022
In 31 healthy adults, 14 days of a four-herb blend containing passionflower lowered self-reported tension and softened stress-response measures during a lab task, though passionflower's own share can't be separated.
Journal of PsychopharmacologyRandomised trial, 2004
In 18 healthy adults, a single 600 mg lemon balm extract dose raised self-rated calmness during a stress test, and 300 mg sped up math speed without hurting accuracy.
Psychosomatic MedicineRandomised trial, 2003
In 20 healthy young adults, a single 1600 mg dried lemon balm leaf dose improved memory and calmness for hours, though slowing memory and visual tasks grew at lower doses.
NeuropsychopharmacologyRandomised trial, 2021
In 49 adults with raised blood pressure, 400 mg lemon balm for four weeks lowered systolic from about 152 to 130, diastolic from 95 to 80 mmHg, more than placebo.
Phytotherapy ResearchRandomised trial, 2023
In adults with raised blood sugar readings and low mood scores, Melissa officinalis lowered self-reported anxiety and low-mood questionnaire scores compared with placebo.
BMC complementary medicine and therapiesMeta-analysis, 2026
Melatonin improved insulin resistance markers in the pooled trials, while fasting blood sugar showed no detectable change.
Meta-analysisMeta-analysis, 2025
A review pooling trials of melatonin alongside fertility treatment reports combined effects on whatever outcomes those trials measured, without giving specific figures.
BMC Pregnancy and ChildbirthMeta-analysis, 2025
Across over 20 trials, magnesium raised HDL cholesterol by about 1.2 mg/dL but showed no clear change in LDL, total cholesterol or triglycerides.
Nutrition JournalRandomised trial, 2026
A hop-derived compound was linked to shifts in gut bile acid markers and symptom scores in one study, but these are markers, not outcomes, within a larger mix tested.
Molecular Nutrition and Food ResearchReview, 2024
A literature review of natural supplements used for sleep placed valerian among the most studied, with reported benefits on self-reported time to fall asleep that were not consistent across trials.
Psychiatry investigationSystematic review, 2010
In a review of herbal and nutritional supplements taken for feelings of anxiousness, valerian trials gave mixed results and the authors judged the supporting evidence limited.
Nutrition journalRandomised trial, 2023
In 323 older adults with subjective or mild memory complaints, 96 weeks of a lemon balm extract supplying 500 mg of rosmarinic acid a day produced no detectable difference from placebo on the main cognitive measures or on hippocampal volume.
The paperPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
Magnesium bound to citric acid, and soluble in water.
In a 24-week randomised double-blind placebo-controlled trial in 164 overweight and slightly obese adults (mean age 63.2 years, 63.4 per cent women) at 450 mg elemental magnesium daily, magnesium citrate raised plasma magnesium by 0.04 mmol/L (95 per cent CI 0.02 to 0.06) and 24-hour urinary magnesium by 3.12 mmol/24 h (95 per cent CI 2.23 to 4.01) against placebo, a larger urinary rise than oxide or sulfate. On the primary outcome, carotid-to-femoral pulse wave velocity, and on blood pressure, no formulation differed from placebo at 24 weeks. In an 8-week randomised double-blind placebo-controlled trial in 76 analysed calcium stone formers with idiopathic hyperoxaluria, magnesium citrate 120 mg three times daily lowered 24-hour urinary oxalate by 16.99 (SD 18.02) and reduced the calcium oxalate supersaturation index against placebo (p = 0.011 and p = 0.010).
Extraction restricted to root tissue, declared as a percentage of total withanolides measured by HPLC.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.
D3 absorbs calcium, K2 directs it to bones, Mg activates D3. The complete calcium optimization system.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
