Berberine HClHbA1c
Average change in the trialsAbout 0.73 percentage points lower HbA1c.
- Measured in
- people with type 2 diabetes, berberine alone or added to standard therapy
- Confidence interval
- 0.51 to 0.97 points lower
Berberine 500mg Capsules
Berberine 500mg Capsules.
Verified by IngredientMD
For metabolism-minded adults running a single-active stack. A clean 97% standardized extract with a single active and no filler. Berberine carries some of the strongest metabolic evidence in the supplement aisle, and 500mg capsules give you precise control over your daily protocol.
Clinically dosed97% standardized extractSingle-ingredient formula
1Active ingredientStrongResearch strength13Human studies
Verified by IngredientMDThe receipts
Strong
Research strength
13
Human studies
Lowers fasting blood glucose and HbA1cMeta-analysis of 14 RCTs
Reduces LDL cholesterol and triglyceridesSystematic review of 27 RCTs
500 mg per serving sits inside the studied 500 mg-1.5 g range
Berberine HCl, Yin 2008 meta + Dong 2012 glucose study
Cross-checked against 274 documented interactions for these actives.
Read the evidenceBerberine HCl, the evidence →
Inside the formula
The size of the effect, in plain numbers.
Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.
Read at the source. The magnitude sits beside the same trial the claim already cites. It describes what the trials measured, never what any one person will feel.
How to useChecked 2026-09-10
What the trials show about timing.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
- EarlyBerberine HClabout 7 days of daily useBuilds with daily use
In a placebo-compared trial, 8 healthy young adults took 1.5 g of berberine daily for 7 days before running an hour in 35 degree heat. Mean body temperature, heart rate, respiratory rate, thermal sensation and general discomfort during the run were all modestly lower with berberine than placebo. One small trial of 8 people.
Van Arman et al., 2026 (Physiological Reports)PMID 42204774
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
In contextChecked 2026-09-10
The gap this formula speaks to.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
Daily usePublished 2024
59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 2024Daily usePublished 2015
61% to 74%
of adults refilling a daily long-term medicine on their own had stopped within a year, against 33% to 44% of those whose refills were scheduled to one recurring pickup day, in a matched pharmacy cohort.
Cohort study, 2015Berberine HCl2026-07-24
Meta-analysis, 2023
Pooling 20 trials in about 1,761 adults, berberine lowered fasting blood sugar by roughly 0.5 mmol/L.
The Journal of NutritionZhao et al., 2023 (The Journal of Nutrition)PMID 37598753
Berberine HCl2026-07-24
Meta-analysis, 2025
Across trials, berberine lowered LDL cholesterol by about 0.5 mmol/L and triglycerides by about 0.37 mmol/L.
Frontiers in PharmacologyLiu et al., 2025 (Frontiers in Pharmacology)PMID 40740996
Berberine HCl2026-07-24
Meta-analysis, 2020
Across 12 randomized trials, berberine reduced body weight by about 2 kg and body mass index by roughly 0.5 kg/m2.
Clinical Nutrition ESPENAsbaghi et al., 2020 (Clinical Nutrition ESPEN)PMID 32690176
Berberine HCl2026-07-24
Meta-analysis, 2024
In adults with metabolic strain, berberine lowered fasting blood sugar by 0.77, a long-term blood sugar marker by 0.57, an insulin resistance marker by 1.04, and two inflammation markers.
Clin TherNazari et al., 2024 (Clin Ther)PMID 38016844
Berberine HCl2026-07-24
Meta-analysis, 2020
Across 10 clinical trials, berberine was associated with a lower body mass index (-0.29 kg/m2) and waist circumference (-2.75 cm), with no detectable change in body weight (-0.11 kg, confidence interval -0.99 to 0.76).
Complement Ther Clin PractXiong et al., 2020 (Complement Ther Clin Pract)PMID 32379652
Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Chemical formChecked 2026-09-10
The same mineral, carried differently.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
- Berberine hydrochloride
Berberine is a plant isoquinoline alkaloid that carries a permanent positive charge. The hydrochloride is that alkaloid cation paired with a chloride ion as a crystalline salt, which is the form the raw alkaloid is most often crystallised into for supplements.
- Fits
- It is the form used in most of the berberine research and on most panels, so a formula built on it lines up with the material that has actually been studied, and it is inexpensive and stable as a dry powder.
- Trade-off
- The salt is only sparingly soluble in water, so panels usually split it into two or three smaller servings across the day rather than a single serving, which is a less convenient dosing schedule.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
Capsule
It is a capsule, so the amount per serving is fixed and travels without measuring.
Best forMost standard doses, and anywhere a short, clean label is the point.
Questions shoppers ask
- Is Berberine 500mg Capsules independently verified?
- Yes. IngredientMD reviewed this formula independently and verified it in Jul 2026. The verdict is earned, not bought: brands can't edit or purchase it.
- What's in Berberine 500mg Capsules?
- Berberine 500mg Capsules is built on Berberine HCl. Each ingredient links to its own evidence page on IngredientMD.
- Were ingredient interactions checked?
- Yes. The combination was screened against 274 documented interactions for these actives in IngredientMD's interaction database.
- Who is IngredientMD?
- IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
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