SPECIMEN #DOCTORS-
Verified
MOODDoctor's Best
SAMe 400mg
SAMe has meta-analyses showing antidepressant effects rivaling some prescription drugs. 400mg is a real therapeutic dose for mood, joints, and liver. The price reflects genuine manufacturing difficulty. DO NOT combine with SSRIs.
8.5/10
EXCELLENTSAMe at 400mg is a real therapeutic dose. Clinical trials for depression typically use 400-1600mg daily. SAMe rivals some antidepressants in head-to-head trials (Papakostas 2010 meta-analysis). The tosylate disulfate form is the most stable. Enteric coating protects from stomach degradation. Single-ingredient simplicity at clinical dose for mood support.
1 ingredientTablets60 servings
Evidence
7.0
Dosing
5.0
SynergyN/A (single ingredient)
What We Like
- SAMe has meta-analyses showing antidepressant effects.
- 400mg is a clinical dose (many studies use 400-1600mg).
- Triple benefit: mood + joints + liver.
- Enteric coating protects the unstable molecule.
Watch Out For
- Expensive ($30-40 for 60 tablets) due to manufacturing difficulty.
- SAMe is inherently unstable (quality varies between brands).
- Must not combine with serotonergic drugs.
- Empty stomach requirement reduces convenience.
What We Analyzed
Verified Supplement Facts
Every dose checked against clinical research
We analyzed the actual supplement facts panel for this product. Every ingredient dose below was cross-referenced with published clinical trials to determine if it matches what studies actually use.
1 ingredients analyzed1 underdosed
Source: Official product page
Ingredient Breakdown
1 underdosed
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
In our database (click to learn more) Not yet reviewed
Our Analysis
Personalized Deep Analysis
See exactly how this fits your health profile. What works for you, what doesn't, and whether you're getting your money's worth.
Unlock with ProTaking other supplements too?
Check your full stack for interactions, redundancies, and gaps. Takes 30 seconds.
0 views