The most potent natural senolytic (zombie cell killer) in animal studies. Mayo Clinic is running human trials. But zero published human results. We don't know the dose, frequency, or safety in humans. Exciting science. Premature supplementation.
Fisetin at 500mg hits 100% of the theoretical optimal dose. But the evidence base is almost entirely preclinical (mouse studies). Zero completed human longevity trials. Mayo Clinic trials are ongoing. The compound itself is genuinely promising as a senolytic, but scoring a product on speculative science is generous. Good dose of a potentially great compound with insufficient human evidence.
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