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Life Extension Life Extension Optimized Folate
SPECIMEN #LIFE-EXT
VITAMINLife Extension

Life Extension Optimized Folate

High-potency folate for heart and brain health.. The database flagged this as underdosed due to a unit conversion error. 8.5 mg is actually 8,500 mcg. That is a massive, therapeutic dose of the bioactive L-5-MTHF form. It is perfect for those who need serious homocysteine support.

8.5/10
EXCELLENT

Folate at 8500mcg DFE as 5-MTHF (methylfolate). This is well above the standard 800mcg optimal dose, but methylfolate at high doses is used therapeutically for MTHFR variants and depression augmentation. The bioactive form bypasses the MTHFR enzyme entirely. Well above the 1000mcg UL for folic acid, but methylfolate has a better safety profile than folic acid at high doses.

1 ingredientTablets100 servings
Evidence
7.0
Dosing
10.0
SynergyN/A (single ingredient)
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What We Like

  • Bioactive 5-MTHF form
  • Massive therapeutic dose
  • High manufacturing standards

Watch Out For

  • Potentially too high for general use
  • Requires B12 monitoring

What We Analyzed

Life Extension Optimized Folate Supplement Facts

Verified Supplement Facts

Every dose checked against clinical research

We analyzed the actual supplement facts panel for this product. Every ingredient dose below was cross-referenced with published clinical trials to determine if it matches what studies actually use.

7 ingredients analyzed

Source: Official product page

Ingredient Breakdown

Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Folate10.0
8500 mcgOVERDOSED
1063%
8500 mcg

of 800mcg

OVERDOSED
1063%
In our database (click to learn more) Not yet reviewed
Other Ingredients(inactive)

microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate

Our Analysis

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