About 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisDHA is the lead active here, studied most for nutrition while breastfeeding. In the 830 mg Total Omega-3s with one other, listed second. Vitamin D3 is the most studied active here, with 20 human studies behind it, each one cited. Each serving carries 480 mg of DHA, inside the range the published research used. Who it fits: made for women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 4 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 1 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisUnder 250 mg a day
US adults average well under the 250 mg a day of EPA and DHA that health authorities suggest for heart health.
Peer-reviewed analysisMore than 97% of US women aged 19 and over
take in less vitamin D from food and drink than the estimated average requirement.
NHANESMore than 97% of US women aged 51 to 70
take in less vitamin D from food and drink than the estimated average requirement.
NHANES57.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics27.5 years, the 2023 US age at first birth
, was up from 26.6 years in 2016 among US women having their first birth, according to the CDC National Center for Health Statistics.
CDC National Center for Health Statistics, 20255.5% of US women aged 20 to 44
who were not pregnant or lactating fell below the estimated average requirement for iron from food alone, in the same NHANES analysis covering 2007 to 2018.
Murphy et al., Nutrients journal, 202234% of US women
aged 18 to 45 who had been or were pregnant said they started taking a prenatal vitamin or multivitamin before they knew they were pregnant, in a national survey run for the March of Dimes.
The Harris Poll for March of Dimes, 201744% to 48% of US pregnancies
, among women surveyed across 2009, 2011, 2013 and 2015, were reported as occurring about the right time, the largest share of any category, in a study of pregnancy desire from the Guttmacher Institute.
Guttmacher Institute (Kost, Zolna and Murro, Demography), 202359 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2011
In trials giving DHA by itself, DHA lowered triglycerides and raised HDL cholesterol by about 4.5 mg/dL compared with placebo.
The paperMeta-analysis, 2022
Across 71 trials, omega-3 (DHA and EPA together) at 2 to 3 grams a day lowered the top blood pressure number by about 2.6 points.
Journal of the American Heart AssociationSystematic review, 2020
Long-chain omega-3s including EPA lowered blood triglycerides by about 15% in a dose-dependent way, a reduction the review graded as high-certainty evidence.
Cochrane Database of Systematic ReviewsMeta-analysis, 2024
Across 10 trials in 318 athletes, vitamin D3 raised blood vitamin D by about 14.8 nmol/L and hinted at better muscle strength, though few trials leave that uncertain.
Frontiers in NutritionMeta-analysis, 2014
Pooling 30 trials of 5,615 adults, vitamin D gave a small rise in overall muscle strength, with no measurable effect on muscle mass or power.
Journal of Clinical Endocrinology and MetabolismMeta-analysis, 2026
In healthy adults after eccentric exercise, supplements combining EPA and DHA reduced muscle soreness across 9 placebo-controlled trials (Hedges g -0.75, 95% CI -1.14 to -0.36). The trials tested the two fats together rather than EPA alone.
NutrientsMeta-analysis, 2014
EPA and DHA together lowered systolic blood pressure by about 1.5 mmHg and diastolic by about 1 mmHg, with a larger drop in people who started with higher blood pressure.
The paperMeta-analysis, 2026
Across 96 trials, EPA with DHA raised blood omega-3 levels and lowered several inflammation markers, with 1 to 3 grams a day the most consistent dose, all markers not outcomes.
Critical Reviews in Food Science and NutritionMeta-analysis, 2024
Across 20 studies, daily vitamin D3 raised blood vitamin D levels by about 10.4 nmol/L more than the same dose of vitamin D2, roughly 40 percent more.
Advances in NutritionRandomised trial, 2026
In 72 healthy adults given omega-3 for 12 weeks, krill oil raised blood omega-3 levels about 1.5 times more than fish oil.
The American Journal of Clinical NutritionRandomised trial, 2026
In 26 amateur runners, 12 weeks of DHA and EPA raised red blood cell omega-3 levels while placebo stayed the same, blood markers not performance outcomes.
Prostaglandins, Leukotrienes and Essential Fatty AcidsMeta-analysis, 2012
In trials directly comparing the two forms, vitamin D3 raised blood 25-hydroxyvitamin D more than vitamin D2 did (P = 0.001).
American Journal of Clinical NutritionMeta-analysis, 2021
Pooling 11 randomised trials of EPA and DHA taken during pregnancy or breastfeeding, the authors did not find consistent evidence of an effect on the children's measured cognitive outcomes or on birth weight.
Nutrition ReviewsMeta-analysis, 2014
Across 23 trials of 4,082 adults, vitamin D raised bone mineral density at the femoral neck by about 0.8%, with no measurable change at the spine, hip, or other sites.
LancetRandomised trial, 2026
In 365 adults aged 55 to 80 with low dietary DHA, 2 g of DHA daily raised the spinal fluid DHA to arachidonic acid ratio at 6 months (difference 0.19, 95% CI 0.16 to 0.21), with no difference detected in brain volumes or cognitive scores over 24 months.
EBioMedicineRandomised trial, 2025
Vitamin D3 supplementation changed the inflammatory protein CHI3L1 and oxidative stress markers in adults with a chronic demyelinating condition. These are markers, not clinical outcomes.
Neuropsychopharmacology ReportsMeta-analysis, 2024
Pooling 9 randomised trials of DHA given before or after birth, infants in the DHA groups scored 1.47 points higher on the Psychomotor Development Index (95% CI 0.23 to 2.72), with no difference detected on the Mental Development Index.
Frontiers in NeurologyRandomised trial, 2010
Formula-fed infants given DHA-enriched formula from 0.32% of fatty acids developed better visual acuity by 12 months than infants on DHA-free formula.
American Journal of Clinical NutritionPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.
In the trial record, EPA in blood plasma plateaus after 4 to 8 weeks of daily fish oil, while EPA in the red blood cell membrane rises with a 28 day half-life and reaches a steady state at about 180 days.
In a randomised single-blind trial, 20 participants took either fish oil supplying 1,296 mg EPA and 864 mg DHA daily or flaxseed oil for eight weeks, with erythrocyte membrane and plasma samples drawn at weeks 0, 4, 8, 10, 12, 14, 16 and 24. On fish oil, erythrocyte membrane EPA rose 300 percent and DHA rose 42 percent by week eight. Levels held until about week 12 and then declined across the post-supplementation sampling, faster in plasma phospholipids than in erythrocyte membranes. Membrane fatty acid content was measured, not a symptom, and this is one trial of 20 people.
In a randomised double-blind crossover trial, healthy men and women aged 19 to 34 took capsules supplying about 4 g DHA per day, with plasma sampled at days 0, 1, 3, 7, 14 and 28. DHA concentrations tripled and so did DHA-derived oxylipins. Increases were detectable as early as day 1, and 11 of 12 individual DHA oxylipins plus total DHA oxylipins reached a plateau by days 5 to 7. The plateau came earlier and was reached by more oxylipins in females than in males. Plasma marker chemistry was measured, not a feeling.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Three ingredients, from each one's own page.
25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.
For the omega-3 index to settle at its new level. Triglyceride readings on a blood panel usually move sooner, inside four to eight weeks.
Membranes fill slowly. The omega 3 index moves over eight to twelve weeks, and the trials reporting cognitive or eye comfort changes run three to six months.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.
In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.
DHA and EPA are the two long-chain omega-3 fatty acids, and they build into cell membrane phospholipids side by side. DHA is the dominant structural fat of nerve and eye tissue, while EPA is a key precursor the body uses for its own resolution-phase signaling lipids, which is why fish and algal oils carry the pair together.
Established omega-3 biochemistry. No combination trial has tested this exact pairing.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.