The people it speaks toFieldwork March 2022
24% of US adults
say digestive health is the most important aspect of their overall health, per a 2022 IFIC survey on gut health and probiotics.
International Food Information Council, 2022Synbiotic+
Synbiotic+.
Backed by human trials
Lactobacillus rhamnosus is the lead active here, studied most for a balanced gut microbiome. In the 11 billion CFU+ Probiotic Blend with one other, listed first. 8 human studies on Lactobacillus rhamnosus back this formula, each one cited. Who it fits: for everyone, adults.
Full label disclosure
9Active ingredients17Human studies300 mgTributyrin
Verified by IngredientMDHow we read this product
- 01We read the label.
The panel on the left is the one we evaluated, line by line.
- 02Every active, separately.
All 9 actives checked against the clinical evidence: dose, form, and what the research actually shows.
- 03Then the formula as a whole.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
- 04Earned, not bought.
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
The receipts
17
Human studies
300 mg
Tributyrin
Cross-checked against 13 documented interactions for these actives.
Inside the formula
Probiotic Blend
A 11 billion CFU+ blend of two ingredients, listed by weight.
Supporting roleLactobacillus rhamnosus
A balanced gut microbiome. In the 11 billion CFU+ Probiotic Blend with one other, listed first.
Key driverBifidobacterium animalis ssp. lactis
Feeding the bacteria that make butyrate. In the 11 billion CFU+ Probiotic Blend with one other, listed second.
Supporting rolePreforPro
A 15 mg blend of four ingredients, listed by weight.
Supporting roleLH01 - Myoviridae
A balanced gut microbiome. In the 15 mg PreforPro with three others, listed first.
Supporting roleLL5 - Siphoviridae
A balanced gut microbiome. In the 15 mg PreforPro with three others, listed second.
Supporting roleT4D - Myoviridae
A balanced gut microbiome. In the 15 mg PreforPro with three others, listed third.
Supporting roleLL12 - Myoviridae
A balanced gut microbiome. In the 15 mg PreforPro with three others, listed fourth.
Supporting roleTributyrin
Gut barrier integrity
Well studiedIn context
The gap this formula speaks to.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
The people it speaks toFieldwork January 22 to 26, 2026
52% of US adults
believe common digestive symptoms such as bloating and abdominal pain are just a normal part of life, per a 2026 Harris Poll conducted for Oshi Health.
The Harris Poll for Oshi Health, 2026This formulaNHANES 2017-2018, published 2021
57.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health StatisticsThe people it speaks toFieldwork 2017 to 2018
58% of the recommended fiber intake
was reached on average by US consumers, who ate 8.1 grams of fiber per 1,000 calories in 2017 to 2018 versus the 14 grams recommended, per USDA Economic Research Service analysis of federal food consumption survey data.
USDA Economic Research Service, 2023The people it speaks toFieldwork March 28 to 29, 2023
40% of US adults
aged 18 and over report they experience bloating at least a few times a month, with 5% saying they experience it daily, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 2023The people it speaks toFieldwork March 28 to 29, 2023
34% of US adults
aged 18 and over report they experience abdominal discomfort or pain at least a few times per month, with women about twice as likely as men to report it several times weekly, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 202317 more
28% of US adults
aged 18 and over say that digestive issues impact the quality of their life, a share that rises to about a third among those aged 18 to 44, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 202332% of US adults
say they actively try to consume probiotics, and among them 60% try to do so at least once a day, per a 2022 IFIC survey on gut health.
International Food Information Council, 202259 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Randomised trial, 2025
Combined supplementation with the BLa80 and LRa05 strains altered measured microbial and biochemical parameters.
Beneficial MicrobesLiu Y et al., 2025 (Beneficial Microbes)PMID 40527514
Randomised trial, 2020
In 68 healthy adults over 4 weeks, adding a bacteriophage blend to a probiotic improved a self-reported gut symptom score within that group and raised beneficial gut bacteria more than the probiotic alone.
NutrientsGrubb et al., 2020 (Nutrients)PMID 32824480
Narrative review, 2024
The review sets out how phage predation shapes gut bacterial community composition, with most supporting evidence coming from culture and animal models rather than human outcome trials.
Gut MicrobesMahmud et al., 2024 (Gut Microbes)PMID 39167701
Randomised trial, 2024
Reports glycaemic index, lipid panel and microbiome composition measures in adults supplemented with Lactobacillus rhamnosus. All three are laboratory markers rather than clinical outcomes.
FoodsChaiyasut C et al., 2024 (Foods)PMID 38731665
Randomised trial, 2026
Evaluates a preparation containing Lactobacillus rhamnosus across clinical, biological and patient-reported measures in a single trial. The multidimensional design is the paper's contribution.
NutrientsMaragno P et al., 2026 (Nutrients)PMID 42123931
Randomised trial, 2022
A low glycaemic index energy-restricted diet changed faecal short-chain fatty acid concentrations, while adding Lactobacillus rhamnosus did not produce a detectable additional change. A failure to detect a difference, not evidence that none exists.
European Review for Medical and Pharmacological SciencesRandomised trial, 2026
Lactoferrin combined with the BB-12 strain improved the study's reported endpoints compared with control.
Frontiers in PediatricsShi Z et al., 2026 (Frontiers in Pediatrics)PMID 42038244
Randomised trial, 2026
The BLa80 strain was reported to lower the incidence of the trial's skin and respiratory endpoints in early childhood.
Frontiers in NutritionChen K et al., 2026 (Frontiers in Nutrition)PMID 42293186
Randomised trial, 2026
Supplementation with the two-strain combination shifted measured gut microbiota composition relative to control.
European Journal of NutritionChen K et al., 2026 (European Journal of Nutrition)PMID 42090020
Randomised trial, 2026
A 12-month randomised trial measuring progression of early enamel lesions in children given a probiotic supplement.
European Journal of Oral SciencesSystematic review, 2025
The review pooled probiotic trials in a specific paediatric population and found limited and heterogeneous data.
Frontiers in NutritionToh QY et al., 2025 (Frontiers in Nutrition)PMID 41200143
Randomised trial, 2026
A randomised trial of early postoperative synbiotic supplementation, with Lactobacillus rhamnosus among the strains, reporting gastrointestinal tolerance measures after bariatric surgery.
Clinical NutritionAltunsaray A et al., 2026 (Clinical Nutrition)PMID 42400993
Randomised trial, 2026
Reports executive function test scores in children given a probiotic supplement. Cognitive test scores are measures of performance on the task, and the report should be read at that level.
Neuropsychopharmacology ReportsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Every one of these is a fact the engine could ground.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
- Studied in people8 human studies on Lactobacillus rhamnosus back this formula, each one cited.
- A mechanism that is settledHow Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis work is settled pharmacology.
- Studied together, not just separatelyLL12 - Myoviridae and Lactobacillus rhamnosus have been studied together, not only separately.
- Why this formatIt is a capsule, so the amount per serving is fixed and travels without measuring.
- The exact form, describedThe label names its forms exactly: Lyophilised Lactobacillus rhamnosus, CFU-declared, Lyophilised culture, Freeze-dried phage powder. The record says what each one is and what it suits.
- A declared blend totalPreforPro declares its total, 15 mg per serving, with 4 ingredients listed by weight.
- Where it comes from and how it is madeLactobacillus rhamnosus is made by fermentation.
- Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
- A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
How each ingredient usually behaves over time.
8 ingredients, from each one's own page.
- Lactobacillus rhamnosusAbout one to two weeks
Most people notice digestive changes over one to two weeks. Immune related measures in trials are read after eight to twelve weeks of continuous use.
- Bifidobacterium animalis ssp. lactis
Most of the change lands in weeks two to four, showing up in stool frequency and comfort rather than as a sensation.
- PreforProTwo to four weeks
For digestive comfort. Stool testing picks up the shift in which bacteria dominate well before you would notice anything.
- LH01 - Myoviridae
No onset has been measured for this phage on its own, and no dose figure is on record. What it does happens in the gut lumen, showing up in stool measures rather than in sensation.
- LL5 - Siphoviridae
Nobody has published a timeline for this particle on its own. Trials of phage blends run about four weeks and read out on stool bacterial counts.
- T4D - Myoviridae
Nothing lands on a felt timeline. Phage studies read stool bacterial counts over two to four weeks, so this is measured rather than sensed.
2 more
- LL12 - Myoviridae
No trial has timed this strain on its own. Shifts from phage preparations are measured by stool sampling over two to four weeks rather than felt.
- TributyrinAbout two to four weeks
Digestive comfort tends to settle over two to four weeks of daily use. There is no same-day sensation to wait for.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
Capsule
It is a capsule, so the amount per serving is fixed and travels without measuring.
Best forMost standard doses, and anywhere a short, clean label is the point.
Questions shoppers ask
- Is Synbiotic+ independently verified?
- Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
- What's in Synbiotic+?
- Synbiotic+ is built on Probiotic Blend, Lactobacillus rhamnosus, Bifidobacterium animalis ssp. lactis, PreforPro, LH01 - Myoviridae, LL5 - Siphoviridae, and more. Each ingredient links to its own evidence page on IngredientMD.
- Were ingredient interactions checked?
- Yes. The combination was screened against 13 documented interactions for these actives in IngredientMD's interaction database.
- Who is IngredientMD?
- IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
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