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Active B12 with L-5-MTHF Lozenges

Two active B12 coenzyme forms (methylcobalamin + adenosylcobalamin) with methylfolate, sublingual. Designed by the MTHFR expert (Dr. Ben Lynch). This is what a biochemist would design if they wanted the most complete B12 supplement possible.

9.2/10
EXCEPTIONAL

Dual-form B12 (adenosylcobalamin + methylcobalamin at 800mcg total) is biochemically sophisticated, covering both mitochondrial and methylation pathways. Methylfolate at 800mcg DFE hits optimal dose exactly. Sublingual lozenge delivery bypasses GI absorption issues. Dr. Ben Lynch designed this specifically for MTHFR variants. Both leading ingredients at or near clinical doses in premium forms. A focused, purpose-built product.

2 ingredientsLOZENGE60 servings
Evidence
7.0
Dosing
9.0
Synergy
6.0
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What We Like

  • Two active B12 forms: methylcobalamin + adenosylcobalamin.
  • Methylfolate for MTHFR-safe folate delivery.
  • Sublingual bypasses gut absorption issues.
  • Dr. Ben Lynch formulation (MTHFR expert).
  • 800mcg doses are therapeutic without being excessive.

Watch Out For

  • Niche product for people who understand methylation.
  • Both active B12 forms may be too much methylation for some.
  • Premium pricing.

Ingredient Breakdown

1 clinical1 adequate
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Vitamin B1210.0

Adenosylcobalamin + Methylcobalamin (50:50)

800 mcgADEQUATE
80%
800 mcg

of 1000mcg

ADEQUATE
80%
Folate10.0

L-5-MTHF Methylfolate

800 mcg DFECLINICAL
100%
800 mcg DFE

of 800mcg

CLINICAL
100%
In our database (click to learn more) Not yet reviewed

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