Calcium Magnesium Zinc.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people22 human studies on Zinc back this formula, each one cited.
• A mechanism that is settledHow Calcium and Magnesium work is settled pharmacology.
• Studied together, not just separatelyCalcium and Magnesium have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 1,000 mg of Calcium, inside the range the published research used.
• A stated daily maintenance amountCalcium is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a tablet, so the amount per serving is fixed and it stores well.
• Full label disclosureEvery ingredient on this label carries its own declared amount.
• Where it comes from and how it is madeCalcium is made by mineral.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Calcium + MagnesiumStrength

  In a 12-month randomised, double-blind trial, 98 adults aged 50 and over drank a litre a day of either a naturally calcium- and magnesium-rich mineral water or a low-mineral water. The mineral-rich group had fewer falls at the 6-month assessment and higher appendicular muscle mass, with the minerals delivered as drinking water rather than a capsule.

  Moretti et al., 2026 (Nutrients)PMID 41683292

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

The size of the effect, in plain numbers.

Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Calciumwithin about one to six hours of a single doseMeasured within a day

  A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.

  Bristow et al., 2015 (Br J Nutr)PMID 25851635

  Thomas et al., 2008 (Calcif Tissue Int)PMID 18553042

  Promising
• Zincover about five days of lozenges started within 24 hours of symptom onsetBuilds with daily use

  Across three randomised placebo-controlled trials pooled as individual patient data (199 adults with naturally acquired colds, 80 to 92 mg of elemental zinc a day as acetate lozenges), 70 percent of the zinc group had recovered by day 5 against 27 percent on placebo, and colds ran 2.73 days shorter against a 7 day average duration. A separate meta-analysis of seven lozenge trials (575 participants, doses above 75 mg a day, zinc acetate or zinc gluconate) measured cold duration 33 percent shorter, with no significant difference between the two salts.

  Hemilä et al., 2017 (Open Forum Infect Dis)PMID 28480298

  Hemilä et al., 2016 (Br J Clin Pharmacol)PMID 27378206

  Hemilä, 2017 (JRSM Open)PMID 28515951

  Strong
• Zincabout two to four weeks of daily intakeBuilds with daily use

  In a controlled feeding study in nine healthy men, six weeks of restricted zinc intake raised DNA strand breaks in peripheral blood cells, and four weeks of repletion at 11 mg a day, with 20 mg of supplemental zinc for the first seven days, reversed the rise. In a separate randomised placebo-controlled trial in 40 Ethiopian women eating a high-phytate diet, 20 mg a day of zinc sulfate for 17 days lowered mean comet tail moment from 39.7 to 30.0 while plasma zinc did not change significantly. Both windows were measured on a DNA damage marker in blood cells, not on a symptom.

  Song and colleagues 2009, American Journal of Clinical NutritionPMID 19515738

  Joray and colleagues 2015, Nutrition ResearchPMID 25491347

  Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

Four ingredients, from each one's own page.

• Calcium

  No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.

  Its own page, the plain answer on timing ↗

• Magnesium

  A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.

  Its own page, the plain answer on timing ↗

• ZincWithin days

  Blood zinc moves within days. The parts you would notice, skin behaviour and immune resilience, take four to twelve weeks of steady daily intake.

  Its own page, the plain answer on timing ↗

• L-Glutamic Acid

  There isn't an onset to time. Gut cells burn most of an oral dose on first pass, so what it contributes is steady substrate for the nitrogen and glutathione pathways.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• L-glutamic acid

  The free amino acid, sparingly soluble in water and distinctly acidic in solution because both carboxyl groups are available.

  Fits

  Capsules and powders where a sodium-free amino acid is wanted, and as the starting material other glutamate salts are made from.

  Trade-off

  Low water solubility compared with its salts and a sour, sharp taste in an unencapsulated powder.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Tablet

It is a tablet, so the amount per serving is fixed and it stores well.

Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.