24.2% of US adults
aged 18 and over met both the aerobic and muscle strengthening activity guidelines in 2020, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2022Leucine is the lead active here, studied most for strength. In the 5.5g BCAAs (2:1:1 Ratio), listed first. 15 human studies on Leucine back this formula, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 9 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 1,019 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
24.2% of US adults
aged 18 and over met both the aerobic and muscle strengthening activity guidelines in 2020, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202231% of US adults
said they were taking protein supplements such as powders, drinks, or bars, in a Pew Research Center survey fielded in July 2026.
Pew Research Center, 202621.1% of the US population
aged 15 and over took part in sports, exercise, or recreation on an average day in 2023, in the American Time Use Survey.
US Bureau of Labor Statistics, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics41.3% of US men aged 18 to 34
met both the aerobic and muscle strengthening activity guidelines in 2020, the highest rate of any age and sex group, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202237% of US adults aged 18 to 29
said they were taking protein supplements such as powders, drinks, or bars, roughly double the rate among adults aged 65 and over, in a Pew Research Center survey fielded in July 2026.
Pew Research Center, 202659 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Systematic review, 2021
Reviewing 15 studies in adults over 65, leucine had the strongest evidence among supplements for muscle mass, though the overall evidence quality was rated low to moderate.
Nutrition ReviewsMeta-analysis, 2025
Pooling trials in older adults with low muscle mass, leucine supplementation improved muscle mass and strength measures compared with control.
NutrientsSystematic review, 2022
Across many trials in older adults, leucine improved some muscle measures, but its effect on physical performance was less consistent than on muscle mass.
Frontiers in nutritionRandomised trial, 2015
In 16 healthy adults, glutamine for 72 hours after hard knee exercise lowered muscle soreness ratings at 48 hours and sped the return of knee strength.
International Journal of Sport Nutrition and Exercise MetabolismMeta-analysis, 2015
Across 16 trials in 999 older people, leucine-rich protein added about 0.99 kg of lean body mass and about 1.02 kg of body weight versus control, with no measurable change in hand grip or knee extension strength.
The Journal of Nutrition, Health and AgingMeta-analysis, 2018
Across 25 pooled trials in adult athletes, glutamine showed no detectable effect on immune cell counts, aerobic capacity or body composition, and was associated with a small weight reduction of about 1.4 kg.
Clinical NutritionSystematic review, 2019
The review reports that leucine supplementation was associated with improvement in muscle mass measures in older adults, while effects on strength and physical performance were less consistent across the included trials.
NutrientsMeta-analysis, 2015
Pooling nine randomised trials in older adults, leucine raised the muscle protein fractional synthetic rate (standardised mean change 1.08, 95% CI 0.50 to 1.67), with no detectable difference in lean body mass or leg lean mass.
British Journal of NutritionRandomised trial, 2025
A leucine-enriched beta-lactoglobulin preparation was compared with an isonitrogenous whey protein isolate for skeletal muscle protein synthesis, a stable-isotope marker measured over hours rather than a change in muscle size.
NutrientsSystematic review, 2026
Across the trials reviewed, whey and soy protein supplementation alongside resistance training in young adults was associated with changes in training adaptations, with the authors noting variability between studies.
Journal of Dietary SupplementsSystematic review, 2025
Supplementation with milk proteins was reviewed for effects on body composition and anthropometric measures, with results varying by the training and dietary context of the underlying trials.
NutrientsMeta-analysis, 2021
Pooling trials, glutamine was linked to small drops in an inflammation marker and other heart risk markers, with some fat measures unchanged.
BMC cardiovascular disordersSystematic review, 2026
Long-term plant and animal protein supplementation were compared for body composition, muscle strength and physical performance. The review did not detect a clear separation between the two sources, which is a failure to detect a difference rather than evidence that they perform identically.
Frontiers in NutritionRandomised trial, 2019
Whey protein isolate taken during endurance training did not produce a detectable change in cycling performance or the immune measures recorded, which is a failure to detect a difference and not evidence that none exists.
Frontiers in NutritionSystematic review, 2025
A review looked at early protein intake in infancy and later body weight and metabolic measures in children, finding associations across cohorts rather than a demonstrated cause.
The American Journal of Clinical NutritionMeta-analysis, 2024
A pooled analysis of glutamine in adults with major burns reports mixed effect sizes across trials with notable differences between studies.
Journal of Burn Care and ResearchSystematic review, 2022
The review examined arginine and glutamine supplementation against transthyretin concentrations, a protein status marker rather than a clinical outcome.
NutritionMeta-analysis, 2024
Pooling 10 placebo-controlled trials in 352 adults, glutamine showed no detectable change in intestinal permeability overall, with a reduction seen only in the subgroup taking more than 30 g a day for under two weeks.
Amino AcidsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised crossover trial, 12 healthy men aged 19 to 32 consumed 29.6 g of whey protein isolate, with plasma amino acids sampled at 30, 60, 90, 120 and 180 minutes after the dose. Essential amino acids, branched-chain amino acids and leucine all rose significantly from baseline in both arms. The trial's comparison was between a processed isolate and the standard form.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Five ingredients, from each one's own page.
Same day for the protein it adds to a meal. Joint and skin readouts in collagen peptide trials are measured after eight to twelve weeks of daily use.
Plasma amino acids rise within about 30 minutes of drinking it, faster than with intact protein. Changes in muscle repair and body composition are measured over weeks.
The amino acid rise happens inside an hour. Strength and lean mass changes are read at eight to twelve weeks in most trials, alongside resistance training.
The signal fires within an hour or two of a dose. The part you can see is muscle kept or gained over weeks of training rather than a same-day sensation.
Digestive comfort tends to shift over one to two weeks of daily use. There's no same-day hit, because it works as a fuel and a nitrogen carrier, not a stimulant.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
A single iodinated tyrosine residue, a synthesis intermediate rather than a thyronine at all
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.