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Verified by IngredientMD/Dymatize/ISO100 Hydrolyzed Whey
VERIFIED BYingredientMD

ISO100 Hydrolyzed Whey.

Backed by human trialsDymatize, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Dymatize.

Leucine is the lead active here, studied most for strength. In the 5.5g BCAAs (2:1:1 Ratio), listed first. 15 human studies on Leucine back this formula, each one cited. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
9Active ingredients37Human studies25 gProtein
ISO100 Hydrolyzed WheyVerified by IngredientMD
DymatizeIngredientMD
The verdict
Backed by human trials
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Protein: Collagen and connective tissueSupporting role
Hydrolyzed Whey Protein Isolate: StrengthWell studied
Whey Protein Isolate: StrengthExtensively studied
BCAAs (2:1:1 Ratio): A 5.5g blend of one ingredient, listed by weight.Supporting role
Leucine: Strength. In the 5.5g BCAAs (2:1:1 Ratio), listed first.Key driver
Essential Amino Acids (EAAs) Blend: A 6.3g blend of its ingredients, listed by weight.Supporting role
Glutamine: Tissue repairWell studied
Conditionally Essential Amino Acids (CEAAs) Blend: A 2.4g blend of its ingredients, listed by weight.Supporting role
Non-Essential Amino Acids (Non-EAAs) Blend: A 6.5g blend of its ingredients, listed by weight.Supporting role

How we read this product

Source: Supplement facts
Supplement Facts panel for ISO100 Hydrolyzed Whey
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 9 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

37
Human studies
25 g
Protein
4.4 g
Glutamine

Inside the formula

Protein
Collagen and connective tissue
Supporting role
Hydrolyzed Whey Protein Isolate
Strength
Well studied
Whey Protein Isolate
Strength
Extensively studied
BCAAs (2:1:1 Ratio)
A 5.5g blend of one ingredient, listed by weight.
Supporting role
Leucine
15 studies
Strength. In the 5.5g BCAAs (2:1:1 Ratio), listed first.
Key driver
Essential Amino Acids (EAAs) Blend
A 6.3g blend of its ingredients, listed by weight.
Supporting role
Glutamine
12 studies
Tissue repair
Well studied
Conditionally Essential Amino Acids (CEAAs) Blend
A 2.4g blend of its ingredients, listed by weight.
Supporting role
Non-Essential Amino Acids (Non-EAAs) Blend
A 6.5g blend of its ingredients, listed by weight.
Supporting role
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2023

21.1% of the US population

aged 15 and over took part in sports, exercise, or recreation on an average day in 2023, in the American Time Use Survey.

US Bureau of Labor Statistics, 2024
This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
20 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Leucine

Systematic review, 2021

Reviewing 15 studies in adults over 65, leucine had the strongest evidence among supplements for muscle mass, though the overall evidence quality was rated low to moderate.

Nutrition Reviews
Leucine

Meta-analysis, 2025

Pooling trials in older adults with low muscle mass, leucine supplementation improved muscle mass and strength measures compared with control.

Nutrients
Leucine

Systematic review, 2022

Across many trials in older adults, leucine improved some muscle measures, but its effect on physical performance was less consistent than on muscle mass.

Frontiers in nutrition
Leucine

Meta-analysis, 2015

Across 16 trials in 999 older people, leucine-rich protein added about 0.99 kg of lean body mass and about 1.02 kg of body weight versus control, with no measurable change in hand grip or knee extension strength.

The Journal of Nutrition, Health and Aging
Glutamine

Meta-analysis, 2018

Across 25 pooled trials in adult athletes, glutamine showed no detectable effect on immune cell counts, aerobic capacity or body composition, and was associated with a small weight reduction of about 1.4 kg.

Clinical Nutrition
Leucine

Systematic review, 2019

The review reports that leucine supplementation was associated with improvement in muscle mass measures in older adults, while effects on strength and physical performance were less consistent across the included trials.

Nutrients
Leucine

Meta-analysis, 2015

Pooling nine randomised trials in older adults, leucine raised the muscle protein fractional synthetic rate (standardised mean change 1.08, 95% CI 0.50 to 1.67), with no detectable difference in lean body mass or leg lean mass.

British Journal of Nutrition
Whey Protein Isolate

Randomised trial, 2025

A leucine-enriched beta-lactoglobulin preparation was compared with an isonitrogenous whey protein isolate for skeletal muscle protein synthesis, a stable-isotope marker measured over hours rather than a change in muscle size.

Nutrients
Whey Protein Isolate

Systematic review, 2026

Across the trials reviewed, whey and soy protein supplementation alongside resistance training in young adults was associated with changes in training adaptations, with the authors noting variability between studies.

Journal of Dietary Supplements
Whey Protein Isolate

Systematic review, 2025

Supplementation with milk proteins was reviewed for effects on body composition and anthropometric measures, with results varying by the training and dietary context of the underlying trials.

Nutrients
Glutamine

Meta-analysis, 2021

Pooling trials, glutamine was linked to small drops in an inflammation marker and other heart risk markers, with some fat measures unchanged.

BMC cardiovascular disorders
Whey Protein Isolate

Systematic review, 2026

Long-term plant and animal protein supplementation were compared for body composition, muscle strength and physical performance. The review did not detect a clear separation between the two sources, which is a failure to detect a difference rather than evidence that they perform identically.

Frontiers in Nutrition
Whey Protein Isolate

Randomised trial, 2019

Whey protein isolate taken during endurance training did not produce a detectable change in cycling performance or the immune measures recorded, which is a failure to detect a difference and not evidence that none exists.

Frontiers in Nutrition
Glutamine

Systematic review, 2022

The review examined arginine and glutamine supplementation against transthyretin concentrations, a protein status marker rather than a clinical outcome.

Nutrition
Glutamine

Meta-analysis, 2024

Pooling 10 placebo-controlled trials in 352 adults, glutamine showed no detectable change in intestinal permeability overall, with a reduction seen only in the subgroup taking more than 30 g a day for under two weeks.

Amino Acids

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people15 human studies on Leucine back this formula, each one cited.
  • A mechanism that is settledHow Protein and Hydrolyzed Whey Protein Isolate work is settled pharmacology.
  • Studied together, not just separatelyProtein and Whey Protein Isolate have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2019.
  • Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
  • The exact form, describedThe label names its forms exactly: Bone broth protein powder, Hydrolysed whey protein (partially hydrolysed), Membrane-filtered whey protein isolate. The record says what each one is and what it suits.
  • A declared blend totalBCAAs (2:1:1 Ratio) declares its total, 5.5 g per serving, with 1 ingredient listed by weight.
  • Where it comes from and how it is madeProtein is made by animal.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Whey Protein Isolatewithin 30 minutes of a doseMeasured within a day

    In a randomised crossover trial, 12 healthy men aged 19 to 32 consumed 29.6 g of whey protein isolate, with plasma amino acids sampled at 30, 60, 90, 120 and 180 minutes after the dose. Essential amino acids, branched-chain amino acids and leucine all rose significantly from baseline in both arms. The trial's comparison was between a processed isolate and the standard form.

    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

Five ingredients, from each one's own page.

  • ProteinThe same day

    Same day for the protein it adds to a meal. Joint and skin readouts in collagen peptide trials are measured after eight to twelve weeks of daily use.

    Its own page, the plain answer on timing

  • Hydrolyzed Whey Protein IsolateAbout 30 minutes

    Plasma amino acids rise within about 30 minutes of drinking it, faster than with intact protein. Changes in muscle repair and body composition are measured over weeks.

    Its own page, the plain answer on timing

  • Whey Protein Isolate

    The amino acid rise happens inside an hour. Strength and lean mass changes are read at eight to twelve weeks in most trials, alongside resistance training.

    Its own page, the plain answer on timing

  • Leucine

    The signal fires within an hour or two of a dose. The part you can see is muscle kept or gained over weeks of training rather than a same-day sensation.

    Its own page, the plain answer on timing

  • GlutamineAbout one to two weeks

    Digestive comfort tends to shift over one to two weeks of daily use. There's no same-day hit, because it works as a fuel and a nitrogen carrier, not a stimulant.

    Its own page, the plain answer on timing

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Chemical form

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

  • DIT

    A single iodinated tyrosine residue, a synthesis intermediate rather than a thyronine at all

    Fits
    Discussed in the biochemistry of hormone synthesis
    Trade-off
    Chemically not the same substance as diiodothyronine, so a label using the names interchangeably is describing something it may not contain

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Format

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.

Best forGram-scale actives: creatine, collagen, protein, electrolytes, beta-alanine.

Questions shoppers ask

Is ISO100 Hydrolyzed Whey independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in ISO100 Hydrolyzed Whey?
ISO100 Hydrolyzed Whey is built on Protein, Hydrolyzed Whey Protein Isolate, Whey Protein Isolate, BCAAs (2:1:1 Ratio), Leucine, Essential Amino Acids (EAAs) Blend, and more. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 1,019 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by DymatizeWork at Dymatize? This verification is yours to claim →