Milk Thistle Seed 30:1 Extract is the lead active here, studied most for everyday liver support. 7 human studies on Milk Thistle Seed 30:1 Extract back this formula, each one cited. Each serving carries 150 mg of Milk Thistle Seed 30:1 Extract, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 1 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong for its niche".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 11 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
17.0% of US adults
reported binge drinking or heavy drinking in 2024, above the levels the low-risk guideline defines, in the Behavioral Risk Factor Surveillance System.
CDC Behavioral Risk Factor Surveillance System, 202454% of US adults
say they drink alcohol, matching the record low set the previous year, in Gallup's Consumption Habits survey.
Gallup, 2026US adults who drink average 3.2 drinks weekly
, down from an average of 3.9 drinks per week over prior years, in Gallup's Consumption Habits survey.
Gallup, 202613% of Dry January participants
say they plan to cut back on alcohol even after the month is over, in Numerator's research among US alcohol buyers.
Numerator, 202653.0% of calories
consumed by US adults age 19 and older came from ultra-processed foods, in NHANES data covering August 2021 to August 2023.
CDC National Center for Health Statistics, 202530.5% of US adults
slept less than 7 hours on average in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202618.1% of US adults
had trouble staying asleep on most days or every day in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2026US adults drank an average of 44 ounces
of plain water daily, in National Health and Nutrition Examination Survey data covering 2015 to 2018.
CDC, 202459 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2016
In 5 trials in 270 adults with elevated blood sugar, silymarin lowered fasting blood glucose by about 27 mg/dL and HbA1c by about 1 point, though evidence quality was low.
The paperMeta-analysis, 2025
Combining 55 trials in 3,545 adults with raised liver enzymes, silymarin lowered the liver enzymes ALT and AST.
BMC Complementary Medicine and TherapiesRandomised trial, 2025
In 130 healthy adults, a 180-day liquid blend of turmeric, dandelion, milk thistle and ginger moved liver enzyme markers more than placebo, though milk thistle's own share can't be separated.
Frontiers in NutritionRandomised trial, 2024
In 83 adults with elevated liver fat, about 103 mg of silymarin daily for 24 weeks lowered a liver stiffness marker and GGT, with no change in liver fat.
Lipids in Health and DiseaseMeta-analysis, 2024
Pooling 33 trials in 1,943 adults, silymarin lowered LDL cholesterol by about 17 mg/dL, total cholesterol by about 14 mg/dL, and triglycerides by about 26 mg/dL.
AntioxidantsMeta-analysis, 2025
Across 25 studies in 2,283 adults with elevated liver fat, silymarin on its own was associated with a small reduction in LDL cholesterol (SMD -0.25, 95% CI -0.48 to -0.03).
Asia Pacific Journal of Clinical NutritionPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised, open-label crossover pharmacokinetic study, 12 healthy volunteers took single doses of two milk thistle supplement formulations, with blood sampled over 8 hours. Silybin A and B were rapidly absorbed and eliminated in both, and the soft-gel formulation reached higher peak and total exposure than the powdered capsule.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
One ingredient, from its own page.
No same-day sensation. Studies that read liver enzyme markers run four to twelve weeks, so this is a slow, panel-level change rather than something you feel.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
