Magnesium L-ThreonateNHANES 2013 to 2016
About 48% of Americans
take in less magnesium than recommended from food and drink.
NIH Office of Dietary SupplementsMagnesium L-Threonate
Magnesium L-Threonate.
Verified by IngredientMD
People targeting sleep and cognition, not general magnesium repletion. The brain-targeted magnesium, dosed the way the studies ran it: a full 2 g of Magtein per serving. That is the exact form and amount the cognition research used, which most competitors undershoot. Worth knowing this is 145 mg of elemental magnesium, so it is a nootropic play, not your daily magnesium top-up. NSF Certified for Sport and vegan.
Studied doseNSF Certified for SportMagtein branded form
1Active ingredient2 gMagtein per serving145 mgElemental magnesium
Verified by IngredientMDThe receipts
2 g
Magtein per serving
145 mg
Elemental magnesium
2 g Magtein per serving is the studied cognition dose
Magnesium L-threonate, Momentous label; Magtein trial dosing
Cross-checked against 59,000+ documented supplement and drug interactions.
Read the evidenceMagnesium L-threonate, the evidence →
Inside the formula
In context
The gap this formula speaks to.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
Magnesium L-ThreonateBRFSS 2014
More than 1 in 3 US adults
regularly sleep less than the recommended seven hours a night.
Peer-reviewed analysisDaily usePublished 2024
59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 2024Daily usePublished 2015
61% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Magnesium L-Threonate
Randomised trial, 2026
In 100 adults aged 18-45 with sleep complaints, 2 grams of magnesium L-threonate daily for 6 weeks improved cognition and reaction time, but tracked sleep showed no change.
Frontiers in NutritionLopresti and Smith, 2026 (Frontiers in Nutrition)PMID 41601871
Magnesium L-Threonate
Randomised trial, 2016
In adults aged 50 to 70 with memory concerns, 12 weeks of magnesium L-threonate raised an overall thinking score more than placebo.
The paperLiu et al., 2016PMID 26519439
4 more
Randomised trial, 2022
In 109 healthy adults, a magnesium L-threonate formula for 30 days improved overall memory scores more than placebo, with bigger gains in older participants.
NutrientsZhang et al., 2022 (Nutrients)PMID 36558392
Randomised trial, 2024
In adults aged 35 to 55 with sleep problems, 1 gram of magnesium L-threonate daily for 21 days improved deep and REM sleep, energy and alertness versus placebo.
Sleep Medicine: XHausenblas et al., 2024 (Sleep Medicine: X)PMID 39252819
Systematic review, 2024
Across 3 randomised trials and 12 cohorts, the trial evidence was too limited to judge magnesium supplements for cognition, while the cohorts, which show association only, pointed to a mid-range serum magnesium level of about 0.85 mmol/L tracking with better cognitive ageing.
Advances in NutritionChen et al., 2024 (Advances in Nutrition)PMID 39009081
Systematic review, 2025
A Cochrane review of randomised trials of magnesium supplementation for headache prophylaxis. The evidence pooled concerns magnesium salts generally and not the L-threonate form.
Cochrane Database of Systematic ReviewsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Chemical form
The same ingredient, carried differently.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
- Magnesium L-threonate
Magnesium bound to L-threonic acid, a metabolite of vitamin C.
- Fits
- cognition-positioned formulas, where the endpoints its trials measured are memory and reaction time rather than blood magnesium
- Trade-off
- the human trials run on one branded ingredient, the objective sleep measures from a wearable did not move, and a third positive cognition trial tested it inside a combination with phosphatidylserine and vitamins C and D, so the form is not isolated there
In a 6-week two-arm parallel-group randomised double-blind placebo-controlled trial in 100 adults aged 18 to 45 reporting dissatisfied sleep, magnesium L-threonate at 2 g daily produced greater improvement than placebo on the NIH Cognitive Toolbox Total Cognition Composite (p = 0.043), with larger treatment effects on working and episodic memory, greater improvement in reaction time (p = 0.031) and in sleep-related impairment (p = 0.043). There were no group differences on Raven Progressive Matrices (p = 0.953), sleep disturbance (p = 0.316), restorative sleep (p = 0.439), or on any sleep outcome recorded by the wearable tracker. In a randomised double-blind placebo-controlled trial in 83 advanced cancer patients taking oral opioids, it slowed the rise in daily oral morphine dose from day 30 onward.
Lopresti and Smith, 2026 (Frontiers in Nutrition)PMID 41601871
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
Available from Momentous
Verified Jul 2026
Questions shoppers ask
- Is Magnesium L-Threonate independently verified?
- Yes. IngredientMD reviewed this formula independently and verified it in Jul 2026. The verdict is earned, not bought: brands can't edit or purchase it.
- What's in Magnesium L-Threonate?
- Magnesium L-Threonate is built on Magnesium L-Threonate. Each ingredient links to its own evidence page on IngredientMD.
- Were ingredient interactions checked?
- Yes. The combination was screened against IngredientMD's interaction database.
- Who is IngredientMD?
- IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
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