Cross-checked against 59,000+ documented supplement and drug interactions.
The same mineral, carried differently.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
- Magnesium L-threonate
Magnesium bound to L-threonic acid, a metabolite of vitamin C.
- Fits
- cognition-positioned formulas, where the endpoints its trials measured are memory and reaction time rather than blood magnesium
- Trade-off
- the human trials run on one branded ingredient, the objective sleep measures from a wearable did not move, and a third positive cognition trial tested it inside a combination with phosphatidylserine and vitamins C and D, so the form is not isolated there
In a 6-week two-arm parallel-group randomised double-blind placebo-controlled trial in 100 adults aged 18 to 45 reporting dissatisfied sleep, magnesium L-threonate at 2 g daily produced greater improvement than placebo on the NIH Cognitive Toolbox Total Cognition Composite (p = 0.043), with larger treatment effects on working and episodic memory, greater improvement in reaction time (p = 0.031) and in sleep-related impairment (p = 0.043). There were no group differences on Raven Progressive Matrices (p = 0.953), sleep disturbance (p = 0.316), restorative sleep (p = 0.439), or on any sleep outcome recorded by the wearable tracker. In a randomised double-blind placebo-controlled trial in 83 advanced cancer patients taking oral opioids, it slowed the rise in daily oral morphine dose from day 30 onward.
Lopresti and Smith, 2026 (Frontiers in Nutrition)PMID 41601871
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
- Is Magnesium L-Threonate independently verified?
- Yes. IngredientMD reviewed this formula independently and verified it in Jul 2026. The verdict is earned, not bought: brands can't edit or purchase it.
- What's in Magnesium L-Threonate?
- Magnesium L-Threonate is built on Magnesium L-Threonate. Each ingredient links to its own evidence page on IngredientMD.
- Were ingredient interactions checked?
- Yes. The combination was screened against IngredientMD's interaction database.
- Who is IngredientMD?
- IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.