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Verified by IngredientMD/Nature Made/Vitamin E 400 IU
VERIFIED BYingredientMD

Vitamin E 400 IU.

Strong for its nicheNature Made, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Nature Made.

Vitamin E is the lead active here, studied most for filling everyday nutrient gaps. 15 human studies on Vitamin E back this formula, each one cited. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
1Active ingredientWell studiedResearch base15Human studies
Vitamin E 400 IUVerified by IngredientMD
Nature MadeIngredientMD
The verdict
Strong for its niche
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Vitamin E: Filling everyday nutrient gapsKey driver

How we read this product

Source: Supplement facts
Supplement Facts panel for Vitamin E 400 IU
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 1 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong for its niche".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
15
Human studies
180 mg
Vitamin E

Cross-checked against 554 documented interactions for these actives.

Read the evidenceVitamin E, the evidence →

Inside the formula

Vitamin E
15 studies
Filling everyday nutrient gaps
Key driver
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2019

12.3% of US adults

met the fruit intake recommendation and 10.0% the vegetable recommendation in 2019, in the Behavioral Risk Factor Surveillance System across 49 states.

CDC, MMWR, 2022
The people it speaks toFieldwork August 2021 to August 2023

60.2% of US adults aged 20 and over

took a dietary supplement in the past 30 days, and 38.7% took two or more, in the 2021 to 2023 National Health and Nutrition Examination Survey.

CDC National Center for Health Statistics, 2026
8 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Vitamin E

Meta-analysis, 2022

Across 8 trials in 1,002 women, vitamin E taken by mouth reduced reported menstrual cramp pain compared with placebo, with the clearest effect in the first month.

Clinical Nutrition ESPEN
Vitamin E

Randomised trial, 2023

In 160 postmenopausal women with long-standing sleep difficulty, one month of vitamin E brought the median sleep questionnaire score to 6, versus 9 on placebo, where lower means better sleep.

Nutrients
Vitamin E

Meta-analysis, 2023

Across 12 trials in 794 adults with high liver fat, at least 400 IU of vitamin E daily lowered two liver enzyme markers by 7 to 10 and 5 units.

Nutrients
Vitamin E

Meta-analysis, 2025

Across 21 trials, vitamin E lowered oxidized LDL and lengthened the time before LDL starts to oxidize, by about 20.45 units, both lab markers of oxidation.

European Journal of Pharmacology
Vitamin E

Meta-analysis, 2026

Pooling the available trials, adjuvant vitamin E alongside varicocele surgery was associated with better post-operative semen parameters, which are laboratory markers of sperm quality and not fertility outcomes.

Archivio Italiano di Urologia e Andrologia

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people15 human studies on Vitamin E back this formula, each one cited.
  • A mechanism that is settledHow Vitamin E works is settled pharmacology.
  • Recent work on the recordThe most recent study on this record was published in 2020.
  • Why this formatIt is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
  • The exact form, describedThe form on the label is d-alpha-tocopherol (natural). The record says what that form is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeVitamin E is made by more than one route.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Vitamin Eabsorbed slowly, tracked over 72 hoursMeasured within a day

    In a 3-phase crossover using two deuterium-labelled forms of alpha-tocopherol, healthy women absorbed about 55 percent of an oral dose taken with a 40 percent fat meal and about 64 percent with a fat-free meal, with samples tracked over 72 hours. The authors conclude absorption is not limited by absent fat or fasting, and that vitamin E leaves the intestine by a prolonged process.

    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

One ingredient, from its own page.

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Chemical form

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

  • dl-alpha-tocopherol (synthetic)

    Synthetically manufactured alpha-tocopherol supplied as all-rac, a racemic mixture of all eight possible stereoisomers in equal proportion. Four are 2R isomers matching the natural configuration and four are 2S isomers.

    Fits
    Suits cost-sensitive formulas that need a defined single-homologue vitamin E and are dosed in international units, since the IU convention already accounts for the isomer mixture.
    Trade-off
    Only the four 2R stereoisomers carry the vitamin E activity recognised when international units are defined, so a larger milligram amount is written per IU than for the natural form. It is otherwise chemically the same alpha-tocopherol molecule.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Format

Softgel

It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.

Best forFat-soluble actives and oils: vitamin D, vitamin E, omega-3, CoQ10.

Questions shoppers ask

Is Vitamin E 400 IU independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Vitamin E 400 IU?
Vitamin E 400 IU is built on Vitamin E. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 554 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by Nature MadeWork at Nature Made? This verification is yours to claim →