36.5% of US adults
aged 18 and over had pain in a hip, knee, or foot in the past 3 months, in the 2019 National Health Interview Survey.
CDC National Center for Health Statistics, 2020Boron is the lead active here, studied most for bone strength. 2 human studies on Boron back this formula, each one cited. Each serving carries 3 mg of Boron, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 1 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 87 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
36.5% of US adults
aged 18 and over had pain in a hip, knee, or foot in the past 3 months, in the 2019 National Health Interview Survey.
CDC National Center for Health Statistics, 202030.7% of US adults
aged 18 and over had pain in a shoulder, elbow, wrist, or hand in the past 3 months, in the 2019 National Health Interview Survey.
CDC National Center for Health Statistics, 202030.2% of non-Hispanic white women
aged 18 and over reported pain, aching, or stiffness in or around a joint lasting more than 3 months, in the 2013 to 2014 National Health Interview Survey.
CDC National Center for Health Statistics, 201628.4% of non-Hispanic white men
aged 18 and over reported pain, aching, or stiffness in or around a joint lasting more than 3 months, in the 2013 to 2014 National Health Interview Survey.
CDC National Center for Health Statistics, 201695% of US adults
aged 19 and over had vitamin D intake from food and beverages below the Estimated Average Requirement, in National Health and Nutrition Examination Survey data from 2005 to 2016.
National Health and Nutrition Examination Survey analysis, 202018.8% of US adults aged 75 and over
needed the help of another person to carry out routine daily tasks outside the home, and 10.6% needed help with basic daily tasks like bathing or dressing, in the 2014 National Health Interview Survey.
CDC National Center for Health Statistics, 201659 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Narrative review, 2020
Across 11 human studies covering 594 people, 3 mg of boron a day supported bone mineral density through its effects on calcium, vitamin D and sex steroid hormone metabolism.
Journal of Trace Elements in Medicine and BiologyReview, 2013
Calcium fructoborate, a natural boron complex, lowered blood levels of the inflammatory marker C-reactive protein across human studies.
Biological Trace Element ResearchRandomised trial, 2015
In 113 female university students, 10 mg a day of boron taken before and during the period lowered rated pain and shortened its duration versus placebo across two cycles.
Complementary Therapies in Clinical PracticeHuman supplementation study, 2011
In eight healthy men, one week of 10 mg boron a day raised average blood free testosterone and lowered estradiol, alongside drops in two inflammatory markers in the blood.
Journal of Trace Elements in Medicine and BiologyPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
The same eight healthy men then took 10 mg of boron daily with breakfast for seven days, with an 8 a.m. blood draw on day seven. Mean plasma free testosterone increased and mean plasma estradiol decreased significantly, while dihydrotestosterone, cortisol and vitamin D were elevated and all three inflammatory markers fell. The authors describe this as the first human report of a rise in free testosterone after boron intake. There is no placebo arm across the seven days and the sample is eight men, so the one-week figure rests on a single small study.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
One ingredient, from its own page.
Plasma boron tracks intake within a day or two because it isn't stored. The change shows up in mineral balance and hormone measures over a week or two.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.