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Verified by IngredientMD/NOW Foods/NOW Glycine 1000mg
VERIFIED BYingredientMD

NOW Glycine 1000mg.

Strong evidence, strong doseNOW Foods, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by NOW Foods.

Glycine is the lead active here, studied most for sleep quality. 4 human studies on Glycine back this formula, each one cited. Each serving carries 3 g of Glycine, inside the range the published research used. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
1Active ingredientWell studiedResearch base4Human studies
NOW Glycine 1000mgVerified by IngredientMD
NOW FoodsIngredientMD
The verdict
Strong evidence, strong dose
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Glycine: Sleep qualityKey driver

How we read this product

Source: Supplement facts
Supplement Facts panel for NOW Glycine 1000mg
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 1 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
4
Human studies
3 g
Glycine
3 g per serving sits inside the studied 1 g-3 g range
Glycine, Inagawa 2006 + Bannai 2012 sleep studies

Cross-checked against 485 documented interactions for these actives.

Read the evidenceGlycine, the evidence →

Inside the formula

Glycine
Sleep quality
Studied 1 g to 5 g a day
Key driver
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2024

30.5% of US adults

slept less than 7 hours on average in a 24-hour period in 2024, in the National Health Interview Survey.

CDC National Center for Health Statistics, 2026
The people it speaks toFieldwork 2024

54.8% of US adults

woke up feeling well-rested every day or most days in the past 30 days in 2024, in the National Health Interview Survey.

CDC National Center for Health Statistics, 2026
The people it speaks toFieldwork May 2024

74% of US adults

report their sleep is sometimes, often or always disrupted by stress, in a 2024 survey commissioned by the American Academy of Sleep Medicine.

American Academy of Sleep Medicine, 2024
The people it speaks toPublished 2022

2.1% of US adults

reported using melatonin in 2017 to 2018, up from 0.4% in 1999 to 2000, across ten cycles of the National Health and Nutrition Examination Survey.

JAMA, 2022
The people it speaks toFieldwork 2024

15.4% of US adults

had trouble falling asleep, and 18.1% trouble staying asleep, every day or most days in the past 30 days in 2024, in the National Health Interview Survey.

CDC National Center for Health Statistics, 2026
8 more
The people it speaks to

12.9% of US adults

used a sleep aid most days or every day in the past 30 days to help them fall or stay asleep in 2024, in the National Health Interview Survey.

CDC National Center for Health Statistics, 2026
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Glycine

Systematic review, 2023

Across 52 human studies, glycine's clearest effects were on the nervous system, with longer-term use associated with better sleep in healthy adults.

GeroScience
Glycine

Clinical trial, 2025

In an uncontrolled two-week study of 19 adults with a very high body mass index, dietary glycine at 100 mg/kg a day raised plasma glycine and urinary acylglycine excretion, and plasma triglyceride and liver enzyme values fell, with no change in body weight. With no control group these marker shifts cannot be attributed to glycine alone.

Sci Rep
Glycine

Randomised trial, 2025

Enteral glycine raised plasma glycine in critically ill adults. Muscle structure, size and function were also measured, and plasma glycine is a blood marker rather than a functional outcome.

Clinical Nutrition

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people4 human studies on Glycine back this formula, each one cited.
  • A mechanism that is settledHow Glycine works is settled pharmacology.
  • Recent work on the recordThe most recent study on this record was published in 2012.
  • Serving amount inside the studied rangeEach serving carries 3 g of Glycine, inside the range the published research used.
  • A stated daily maintenance amountGlycine is here at a daily maintenance amount, which is what a daily supplement is for.
  • Why this formatIt is a capsule, so the amount per serving is fixed and travels without measuring.
  • The exact form, describedThe form on the label is Glycine (crystalline free amino acid). The record says what that form is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeGlycine is made by more than one route.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Glycinethe morning after a single 3 g dose taken before bedMeasured within a day

    In a placebo-controlled study in healthy volunteers whose sleep was cut to 25 percent below their usual time for three consecutive nights, 3 g of glycine was taken before bedtime and outcomes were measured the following day. Visual analogue scale scores showed a significant reduction in fatigue and a tendency toward reduced sleepiness, and a psychomotor vigilance test improved significantly. The measures were self-rated scales plus one computer-based performance test, not polysomnography. The work was carried out by employees of Ajinomoto Co., Inc, an amino acid manufacturer.

    Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

One ingredient, from its own page.

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Format

Capsule

It is a capsule, so the amount per serving is fixed and travels without measuring.

Best forMost standard doses, and anywhere a short, clean label is the point.

Questions shoppers ask

Is NOW Glycine 1000mg independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in NOW Glycine 1000mg?
NOW Glycine 1000mg is built on Glycine. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 485 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by NOW FoodsWork at NOW Foods? This verification is yours to claim →