L-Citrulline.
L-Citrulline is the lead active here, studied most for warm hands and feet. 16 human studies on L-Citrulline back this formula, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDHow we read this product
- 01We read the label.
The panel on the left is the one we evaluated, line by line.
- 02Every active, separately.
All 1 actives checked against the clinical evidence: dose, form, and what the research actually shows.
- 03Then the formula as a whole.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong for its niche".
- 04Earned, not bought.
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
The receipts
Cross-checked against 131 documented interactions for these actives.
Inside the formula
Every one of these is a fact the engine could ground.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
- Studied in people16 human studies on L-Citrulline back this formula, each one cited.
- A mechanism that is settledHow L-Citrulline works is settled pharmacology.
- Recent work on the recordThe most recent study on this record was published in 2024.
- Why this formatIt is a tablet, so the amount per serving is fixed and it stores well.
- The exact form, describedThe form on the label is L-Citrulline. The record says what that form is and what it suits.
- Full label disclosureEvery ingredient on this label carries its own declared amount.
- Where it comes from and how it is madeL-Citrulline is made by fermentation.
- Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
- A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show about timing.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
- EarlyL-Citrullinewithin about 1 hour of a single doseMeasured within a day
In a randomised double-blind crossover trial in 19 recreationally active women, a single 8 g dose of citrulline malate taken 60 minutes before testing raised total work in a 5-repetition isokinetic leg extension protocol compared with placebo, with no difference in peak torque and no difference in the 50-repetition protocol. A separate crossover trial in 10 well-trained men using 12 g 60 minutes before high-intensity cycling found no change in time to exhaustion or power.
Gills et al., 2023 (J Strength Cond Res)PMID 34319940Cunniffe et al., 2016 (J Strength Cond Res)PMID 26808848
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
How each ingredient usually behaves over time.
One ingredient, from its own page.
- L-Citrulline
Plasma arginine peaks around an hour after a dose, which is when the fuller feeling in working muscle turns up. Performance changes build across one to two weeks.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
The same ingredient, carried differently.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
- L-Citrulline
The non-protein amino acid citrulline in its uncombined free form, not bonded to another acid, mineral, or carrier. Every labelled gram is citrulline itself.
- Fits
- Suits a formula that wants citrulline on its own with no added acid weight, so the panel gram and the citrulline gram are the same number. Folds cleanly into capsules and unflavored or lightly flavored powders.
- Trade-off
- It carries no malic acid, so a brand following a citrulline-malate dosing protocol cannot match gram-for-gram and has to convert. The plain powder can taste faintly bitter in a simple drink mix.
In a randomized double-blind placebo-controlled crossover trial, 10 healthy men took 6 g/day of free-form L-citrulline for 7 days. Tolerance to severe-intensity cycling and total work completed were higher than placebo, while L-arginine at the same dose was not.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
Tablet
It is a tablet, so the amount per serving is fixed and it stores well.
Questions shoppers ask
- Is L-Citrulline independently verified?
- Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
- What's in L-Citrulline?
- L-Citrulline is built on L-Citrulline. Each ingredient links to its own evidence page on IngredientMD.
- Were ingredient interactions checked?
- Yes. The combination was screened against 131 documented interactions for these actives in IngredientMD's interaction database.
- Who is IngredientMD?
- IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
