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Verified by IngredientMD/Real Mushrooms/Lion's Mane Extract
VERIFIED BYingredientMD

Lion's Mane Extract.

Strong evidence, strong doseReal Mushrooms, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Real Mushrooms.

Beta-(1,3)(1,6)-glucans is the lead active here, studied most for a balanced gut microbiome. Organic Lion's Mane Mushroom Extract is the most studied active here, with 6 human studies behind it, each one cited. Each serving carries 1,000 mg of Organic Lion's Mane Mushroom Extract, inside the range the published research used. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
2Active ingredients10Human studies300 mgBeta-(1,3)(1,6)-glucans
Lion's Mane ExtractVerified by IngredientMD
Real MushroomsIngredientMD
The verdict
Strong evidence, strong dose
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Organic Lion's Mane Mushroom Extract: Feeding the bacteria that make butyrateWell studied
Beta-(1,3)(1,6)-glucans: A balanced gut microbiomeKey driver

How we read this product

Source: Supplement facts
Supplement Facts panel for Lion's Mane Extract
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

10
Human studies
300 mg
Beta-(1,3)(1,6)-glucans
1000 mg
Organic Lion's Mane Mushroom Extract
1 g per serving sits inside the studied 500 mg-1 g range
Organic Lion's Mane Mushroom Extract, Mori 2009 + Saitsu 2019 cognitive studies
300 mg per serving sits inside the studied 100 mg-500 mg range
Beta-(1,3)(1,6)-glucans, Akramiene et al. 2007 Medicina review; Vetvicka et al. 2019 Nutrients

Cross-checked against 187 documented interactions for these actives.

Read the evidenceOrganic Lion's Mane Mushroom Extract, the evidence →Beta-(1,3)(1,6)-glucans, the evidence →

Inside the formula

Organic Lion's Mane Mushroom Extract
Feeding the bacteria that make butyrate
Studied 500 mg to 3 g a day
Well studied
Beta-(1,3)(1,6)-glucans
A balanced gut microbiome
Studied 100 mg to 1 g a day
Key driver
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
The people it speaks toFieldwork 2017 to 2018

58% of the recommended fiber intake

was reached on average by US consumers, who ate 8.1 grams of fiber per 1,000 calories in 2017 to 2018 versus the 14 grams recommended, per USDA Economic Research Service analysis of federal food consumption survey data.

USDA Economic Research Service, 2023
The people it speaks toFieldwork March 28 to 29, 2023

34% of US adults

aged 18 and over report they experience abdominal discomfort or pain at least a few times per month, with women about twice as likely as men to report it several times weekly, per a 2023 Ipsos poll conducted for MDVIP.

Ipsos, 2023
13 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Beta-(1,3)(1,6)-glucans

Systematic review, 2024

Human trials of barley and oat beta-glucan reported shifts in immune and inflammatory markers and in gut microbiota composition, with results varying by dose.

Current nutrition reports
Organic Lion's Mane Mushroom Extract

Randomised trial, 2023

In healthy adults, a single 1 gram dose of lion's mane sped up reaction time on memory and attention tests two hours later, compared with placebo.

Nutrients
Beta-(1,3)(1,6)-glucans

Randomised trial, 2025

Yeast beta-glucan supplementation increased the measured antibody response following seasonal influenza vaccination compared with placebo.

Journal of dietary supplements
Organic Lion's Mane Mushroom Extract

Systematic review, 2025

Pooling the controlled trials, participants taking lion's mane showed a combined weighted mean rise of 1.17 points on the Mini-Mental State cognitive scale versus placebo.

Frontiers in Nutrition
Organic Lion's Mane Mushroom Extract

Randomised trial, 2023

In 41 healthy adults aged 18 to 45, a single 1.8 g dose of lion's mane sped up Stroop task performance at 60 minutes (p = 0.005), and 28 days of use showed a trend toward lower self-reported stress that did not reach significance (p = 0.051).

Nutrients
Beta-(1,3)(1,6)-glucans

Randomised trial, 2026

Eight weeks of a yeast cell derived beta-glucan supplement shifted redox and immune response markers in the adults studied.

Nutrients
Organic Lion's Mane Mushroom Extract

Randomised trial, 2025

In 18 healthy adults aged 18 to 35, a single 3 g dose of a 10:1 lion's mane fruiting body extract produced no detectable change in overall cognition or mood scores at 90 minutes, with improvement limited to the pegboard dexterity task.

Frontiers in Nutrition
Organic Lion's Mane Mushroom Extract

Randomised trial, 2009

Adults aged 50 to 80 taking 3 g of lion's mane daily scored significantly higher on a cognitive function scale from week 8 through week 16, and scores fell again 4 weeks after they stopped.

Phytotherapy Research

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people6 human studies on Organic Lion's Mane Mushroom Extract back this formula, each one cited.
  • A mechanism that is settledHow Organic Lion's Mane Mushroom Extract and Beta-(1,3)(1,6)-glucans work is settled pharmacology.
  • Studied together, not just separatelyBeta-(1,3)(1,6)-glucans and Organic Lion's Mane Mushroom Extract have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2023.
  • Serving amount inside the studied rangeEach serving carries 1,000 mg of Organic Lion's Mane Mushroom Extract, inside the range the published research used.
  • A stated daily maintenance amountOrganic Lion's Mane Mushroom Extract is here at a daily maintenance amount, which is what a daily supplement is for.
  • Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
  • The exact form, describedThe label names its forms exactly: Dried fruiting body powder, Oat beta-glucan, barley beta-glucan. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeOrganic Lion's Mane Mushroom Extract is made by more than one route.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Organic Lion's Mane Mushroom Extractwithin about one to two hours of a single doseMeasured within a day

    Two small studies measured a same-day effect. In a randomised, double-blind, placebo-controlled parallel-groups pilot in 41 healthy adults aged 18 to 45, a single 1.8 g dose of lion's mane was followed by quicker Stroop task performance at 60 minutes after dosing (p = 0.005). In a separate randomised, double-blind, placebo-controlled crossover study, a single 1 g dose of Nordic-grown lion's mane was followed by changes in working memory, complex attention and reaction time measures two hours after ingestion. Both samples are small. A third acute crossover in 18 adults using a 3 g dose of a 10:1 fruiting body extract found no effect on composite cognition or mood at 90 minutes, with a change only on an individual pegboard test.

    Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

Two ingredients, from each one's own page.

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Format

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.

Best forGram-scale actives: creatine, collagen, protein, electrolytes, beta-alanine.
Recurring supply suggested

Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.

Questions shoppers ask

Is Lion's Mane Extract independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Lion's Mane Extract?
Lion's Mane Extract is built on Organic Lion's Mane Mushroom Extract, Beta-(1,3)(1,6)-glucans. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 187 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

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