24% of US adults
say digestive health is the most important aspect of their overall health, per a 2022 IFIC survey on gut health and probiotics.
International Food Information Council, 2022Beta-(1,3)(1,6)-glucans is the lead active here, studied most for a balanced gut microbiome. Organic Lion's Mane Mushroom Extract is the most studied active here, with 6 human studies behind it, each one cited. Each serving carries 1,000 mg of Organic Lion's Mane Mushroom Extract, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 187 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
24% of US adults
say digestive health is the most important aspect of their overall health, per a 2022 IFIC survey on gut health and probiotics.
International Food Information Council, 202252% of US adults
believe common digestive symptoms such as bloating and abdominal pain are just a normal part of life, per a 2026 Harris Poll conducted for Oshi Health.
The Harris Poll for Oshi Health, 202657.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics58% of the recommended fiber intake
was reached on average by US consumers, who ate 8.1 grams of fiber per 1,000 calories in 2017 to 2018 versus the 14 grams recommended, per USDA Economic Research Service analysis of federal food consumption survey data.
USDA Economic Research Service, 202340% of US adults
aged 18 and over report they experience bloating at least a few times a month, with 5% saying they experience it daily, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 202334% of US adults
aged 18 and over report they experience abdominal discomfort or pain at least a few times per month, with women about twice as likely as men to report it several times weekly, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 202328% of US adults
aged 18 and over say that digestive issues impact the quality of their life, a share that rises to about a third among those aged 18 to 44, per a 2023 Ipsos poll conducted for MDVIP.
Ipsos, 202332% of US adults
say they actively try to consume probiotics, and among them 60% try to do so at least once a day, per a 2022 IFIC survey on gut health.
International Food Information Council, 202259 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Systematic review, 2024
Human trials of barley and oat beta-glucan reported shifts in immune and inflammatory markers and in gut microbiota composition, with results varying by dose.
Current nutrition reportsRandomised trial, 2023
In healthy adults, a single 1 gram dose of lion's mane sped up reaction time on memory and attention tests two hours later, compared with placebo.
NutrientsRandomised trial, 2025
Yeast beta-glucan supplementation increased the measured antibody response following seasonal influenza vaccination compared with placebo.
Journal of dietary supplementsSystematic review, 2025
Pooling the controlled trials, participants taking lion's mane showed a combined weighted mean rise of 1.17 points on the Mini-Mental State cognitive scale versus placebo.
Frontiers in NutritionRandomised trial, 2023
In 41 healthy adults aged 18 to 45, a single 1.8 g dose of lion's mane sped up Stroop task performance at 60 minutes (p = 0.005), and 28 days of use showed a trend toward lower self-reported stress that did not reach significance (p = 0.051).
NutrientsRandomised trial, 2026
Six weeks of baker's yeast beta-glucan produced a distinct pattern of immune cell gene expression compared with placebo.
International journal of molecular sciencesRandomised trial, 2026
Eight weeks of a yeast cell derived beta-glucan supplement shifted redox and immune response markers in the adults studied.
NutrientsRandomised trial, 2025
In 18 healthy adults aged 18 to 35, a single 3 g dose of a 10:1 lion's mane fruiting body extract produced no detectable change in overall cognition or mood scores at 90 minutes, with improvement limited to the pegboard dexterity task.
Frontiers in NutritionRandomised trial, 2009
Adults aged 50 to 80 taking 3 g of lion's mane daily scored significantly higher on a cognitive function scale from week 8 through week 16, and scores fell again 4 weeks after they stopped.
Phytotherapy ResearchPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
Two small studies measured a same-day effect. In a randomised, double-blind, placebo-controlled parallel-groups pilot in 41 healthy adults aged 18 to 45, a single 1.8 g dose of lion's mane was followed by quicker Stroop task performance at 60 minutes after dosing (p = 0.005). In a separate randomised, double-blind, placebo-controlled crossover study, a single 1 g dose of Nordic-grown lion's mane was followed by changes in working memory, complex attention and reaction time measures two hours after ingestion. Both samples are small. A third acute crossover in 18 adults using a 3 g dose of a 10:1 fruiting body extract found no effect on composite cognition or mood at 90 minutes, with a change only on an individual pegboard test.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
Before most people describe a cognitive change. Nothing about it behaves like a stimulant on day one.
Nothing acute. Viscous cereal forms move a post-meal glucose curve within hours, while cholesterol and immune measures are tracked across four to twelve weeks.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.