Vitamin D3 + K2.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people20 human studies on Vitamin D3 back this formula, each one cited.
• A mechanism that is settledHow Vitamin D3 and Vitamin K2 work is settled pharmacology.
• Studied together, not just separatelyVitamin D3 and Vitamin K2 have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 100 mcg of Vitamin K2, inside the range the published research used.
• A stated daily maintenance amountVitamin K2 is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
• The exact form, describedThe label names its forms exactly: Vitamin D3 in a carrier oil, lanolin-derived, MK-7, all-trans menaquinone-7. The record says what each one is and what it suits.
• Full label disclosureEvery ingredient on this label carries its own declared amount.
• Where it comes from and how it is madeVitamin D3 is made by more than one route.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Vitamin D3 + Vitamin K2Bone

  In a meta-analysis of eight randomized trials, vitamin K2 taken together with vitamin D raised total bone mineral density and lowered undercarboxylated osteocalcin, a marker of vitamin K status.

  Kuang et al., 2020 (Food & Function)PMID 32219282

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin D3about 3 months of daily useBuilds with daily use

  In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

  Vieth et al., 2001 (Am J Clin Nutr)PMID 11157326

  Early
• Vitamin K2about four weeks of daily useBuilds with daily use

  A double-blind randomised dose-finding trial gave 60 postmenopausal women aged 50 to 69 either 0, 50, 100 or 200 micrograms of menaquinone-7 daily for four weeks on a controlled diet. The ratio of carboxylated to undercarboxylated osteocalcin rose dose dependently, with significant differences from the 0 microgram group at 100 and 200 micrograms. A companion 12-week trial in 120 people aged 20 to 69 confirmed the change at 100 micrograms daily. Both studies were run by authors affiliated with the R and D division of J-Oil Mills. An independent 8-week double-blind trial in 55 healthy prepubertal children found the same direction at 45 micrograms daily. What was measured is a blood marker of vitamin K status, not bone density and not a sensation.

  Inaba et al., 2015 (J Nutr Sci Vitaminol (Tokyo))PMID 26875489

  van Summeren et al., 2009 (Br J Nutr)PMID 19450370

  Promising
• Vitamin K2three years of daily use, with measurements at one, two and three yearsBuilds with daily use

  A double-blind randomised trial gave 244 healthy postmenopausal women either placebo or 180 micrograms of menaquinone-7 daily for three years, with bone mineral density measured by DXA at baseline and after each year. Menaquinone-7 decreased the age-related decline in bone mineral content and bone mineral density at the lumbar spine and femoral neck, but not at the total hip. The effect is a slowed decline rather than a gain, and the trial ran three years rather than weeks.

  Knapen et al., 2013 (Osteoporos Int)PMID 23525894

  Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

Two ingredients, from each one's own page.

• Vitamin D3About six to twelve weeks

  25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.

  Its own page, the plain answer on timing ↗

• Vitamin K2Days, not hours

  Days for absorption, weeks for the marker. Undercarboxylated osteocalcin falls across roughly four to twelve weeks of daily intake, and that is a status marker rather than an outcome.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• Cholecalciferol (vitamin D3)

  The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.

  Fits

  Raising and holding vitamin D status, and the form most supplement trials use.

  Trade-off

  Being fat-soluble it accumulates with sustained high dosing, so intakes are set against the tolerable upper level rather than topped up freely.

  In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.

  Peris et al., 2026 (Nutrients)PMID 42124077

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Softgel

It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.

Studied alongside this brand's other formulas

Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.