Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. 27-deoxyactein has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
27-deoxyactein is a triterpene glycoside from the rhizome of Actaea racemosa, and it is one of the compounds used to standardise black cohosh extracts. Nobody takes it in isolation; it arrives as part of a whole extract alongside actein, cimiracemoside and the rest of the glycoside family. Reading it as a marker of extract identity rather than as a standalone ingredient is the accurate framing.
Rare liver injury reports have followed black cohosh use, enough that several regulators require a liver warning on labels even though causality has not been established and adulteration with other Actaea species is a competing explanation. Silymarin is studied for hepatic support. The pairing is a precaution built on mechanism and regulatory caution, not on any trial of the combination.
Isoflavones bind oestrogen receptors directly, particularly the beta subtype. Triterpene glycosides such as 27-deoxyactein do not show meaningful oestrogen receptor binding in the assays that have looked, and the mechanism attributed to black cohosh has moved toward serotonergic and central pathways instead. Combining them stacks two different proposed mechanisms in one product without evidence that either the individual or the combined effect holds.
Black cohosh preparations are sometimes taken in the evening and blended with chamomile in tea and capsule formats. This is formulation habit rather than a documented interaction. Neither compound has been studied against the other.
Nothing specific on file for 27-deoxyactein. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.