Horse nettle.
Research-backed compound with potential health benefits. Contains toxic solanine alkaloids. Can cause poisoning.
Reviewed March 2026
- Category
- Compound
What Horse nettle is, and what it does.
- Does it work
- NO. This plant is TOXIC. Not meant for supplementation.
- How much to take
- No daily amount has been established in people. A 100 to 250mg band sits on our record with no human dosing work behind it, so nothing here is a validated serving.
- Time to feel it
- Nobody has established an onset in people, and no dosing schedule has been characterised. The plant's steroidal alkaloids are studied in the laboratory, not in daily use.
- The first dose
- Nothing about day one has been documented in people. The plant's steroidal glycoalkaloids are studied in the laboratory, and no human dosing schedule exists to describe.
- With regular use
- Nobody has measured weeks of daily use in people. The published work on this plant is laboratory chemistry on its glycoalkaloids rather than anything about regular intake.
- How well tolerated
- NOT SAFE. Poisonous plant. Should not be consumed.
- How it feels
- Subtle at best. Not a perceptible supplement.
- The overlooked benefit
- Its berries carry the same class of steroidal glycoalkaloids found in green potato skin, and that alkaloid chemistry is what laboratory work on this plant actually examines.
100 to 250mg a day is where Horse nettle works.
Source: Solanum carolinense ethnobotany; no clinical supplement studies
The proof, claim by claim.
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
Horse nettle is documented in the library; the clinical read is in the queue. Nothing about the strength of the research prints until the read is done.
- Steroidal glycoalkaloid content of the plantIn vitro study
- Toxicity of solanine-type alkaloidsAnimal study
- Antimicrobial activity of plant extracts in the laboratoryIn vitro study
- Historical folk use of the root and berryNarrative review
Questions people ask about Horse nettle.
- Should I take this?
- Never. This is a toxic weed, not a supplement.
- Is it safe?
- Limited data. Generally considered well tolerated at normal doses, but consult your doctor.
- Where does it come from?
- Various sources. Check product labeling.
- Are there alternatives?
- Whatever you're trying to achieve, there are safe options. This is not one of them.
- How long until it works?
- Varies. Most supplements need weeks to months.
- Can I get it from food?
- Possibly. Check dietary sources.
No pairing data for Horse nettle yet.
Nothing on file for Horse nettle, either from a combination trial or from settled biochemistry. When either lands, it appears here with its source.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
21 pairings are live across the library today. Checked 9 August 2026.
Nothing specific on file for Horse nettle. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.Getting Horse nettle from food.
The whole-food sources on file. A supplement closes the gap, it does not replace dinner.
A gram-for-gram figure (how much of each you would eat to match a dose) will appear here once it is sourced and reviewed. This page will not print a number it cannot cite.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.