Laxogenin (5a-Hydroxy).
Plant steroid marketed as a natural anabolic A plant steroid from Smilax sold for muscle and strength support. In people nothing has been measured, and the published work sits in laboratory and animal studies of related compounds.
Reviewed March 2026
- Category
- Compound
- Also filed under
- Muscle BuildingRecoveryNon Hormonal
What Laxogenin (5a-Hydroxy) is, and what it does.
- Does it work
- It suits lifters who want to try a plant-derived option and are comfortable that no human trial has measured it. It isn't a hormone and doesn't act at the androgen receptor.
- How much to take
- 50 to 100mg a day is the daily maintenance band on record. No human study has established what any amount does, so start at the lower end of what the label states.
- Time to feel it
- Nobody has measured a timeline for this in people. The published work sits in laboratory and animal studies of related plant steroids.
- The first dose
- Nobody has measured what the first 24 hours do here. Anything you notice on day one is the training and the routine around it rather than the compound.
- With regular use
- Weeks of daily use have not been studied in humans. What months of intake do has not been measured, so there is no human record to report.
- How well tolerated
- No human trial has measured tolerability, and long-term use hasn't been studied. Check with your doctor first, especially if you're pregnant, breastfeeding or taking medication.
- How it feels
- There is no published account of a subjective effect. Users describe training sessions feeling easier, and that is a report rather than a measurement.
- The overlooked benefit
- Laxogenin is a spirostanol saponin from Smilax plants, not a hormone. It does not act at the androgen receptor, which the 'natural anabolic' framing often implies.
50 to 100mg a day is where Laxogenin (5a-Hydroxy) works.
Source: No peer-reviewed human clinical trials; supplement industry dosing only
The proof, claim by claim.
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
Laxogenin (5a-Hydroxy) has emerging evidence. Based on 38+ studies.
- lean muscle supportAnimal study
- muscle protein synthesis signallingAnimal study
- plant steroid activity in cellsIn vitro study
- identity and content of marketed materialNarrative review
Questions people ask about Laxogenin (5a-Hydroxy).
- When should I take it?
- Timing matters less than consistency. Pick a time that works for you and take it daily.
- Can I take it with other supplements?
- Usually fine. The main thing to watch is not doubling up on the same ingredient from different products. If you're on prescription meds, check with your pharmacist first.
- Any side effects to watch for?
- Most people tolerate it well at recommended doses. GI upset is the most common complaint with any supplement. Start with a lower dose and work up. If something feels off, stop and reassess.
- Who benefits most from this?
- Honestly, most people would benefit more from the basics. But if you've got a specific reason to try it, the risk is generally low.
No pairing data for Laxogenin (5a-Hydroxy) yet.
Nothing on file for Laxogenin (5a-Hydroxy), either from a combination trial or from settled biochemistry. When either lands, it appears here with its source.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
21 pairings are live across the library today. Checked 9 August 2026.
Nothing specific on file for Laxogenin (5a-Hydroxy). Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.Getting Laxogenin (5a-Hydroxy) from food.
The whole-food sources on file. A supplement closes the gap, it does not replace dinner.
A gram-for-gram figure (how much of each you would eat to match a dose) will appear here once it is sourced and reviewed. This page will not print a number it cannot cite.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.