iMD
IngredientMDYour supplements, diagnosed.
Analyze StackMy Health
All Products
T
Thorne
SPECIMEN #THORNE-M
Verified
B_VITAMINSThorne

Methyl-Guard Plus

The practitioner gold standard for methylation support. Every B-vitamin in its active coenzyme form. Betaine (TMG) provides methyl groups through an alternative pathway. Not a casual B-complex. This is targeted biochemistry for MTHFR and elevated homocysteine.

9.0/10
EXCEPTIONAL

Purpose-built methylation support with every ingredient in its active coenzyme form. 5-MTHF folate at 1700mcg DFE far exceeds optimal (above 800mcg). Methylcobalamin B12 at 2000mcg is at the optimal-to-diminishing threshold. P5P (B6) at 45mg is well within therapeutic range. Riboflavin-5-phosphate at 25mg hits optimal. Betaine (TMG) at 750mg is 50% of optimal for methylation but provides meaningful methyl donor support. The synergy between these methylation cofactors is exceptional.

5 ingredientsCapsules45 servings
Evidence
7.0
Dosing
9.8
Synergy
6.0
Analyze My Stack

What We Like

  • Every B-vitamin in active coenzyme form (P-5-P, methylcobalamin, methylfolate, R-5-P).
  • Betaine (TMG) provides an alternative methylation pathway.
  • Specifically designed for MTHFR variants and elevated homocysteine.
  • Thorne's practitioner-grade quality.

Watch Out For

  • Not a general B-complex (it's targeted for methylation).
  • Premium pricing.
  • May over-methylate some individuals.

Ingredient Breakdown

1 clinical1 underdosed
Clinical Adequate Underdosed Overdosed|Bar = % of clinical dose
IngredientDoseStatusvs. Clinical
Folate10.0

5-MTHF L-Methylfolate

1700 mcg DFEOVERDOSED
213%
1700 mcg DFE

of 800mcg

OVERDOSED
213%
Vitamin B1210.0

Methylcobalamin

2000 mcgOVERDOSED
200%
2000 mcg

of 1000mcg

OVERDOSED
200%
Vitamin B6

Pyridoxal-5-Phosphate

45 mgOVERDOSED
180%
45 mg

of 25mg

OVERDOSED
180%
Vitamin B29.0

Riboflavin-5-Phosphate

25 mgCLINICAL
100%
25 mg

of 25mg

CLINICAL
100%
Betaine7.0

Trimethylglycine

750 mgUNDERDOSED
30%
750 mg

of 2500mg

UNDERDOSED
30%
In our database (click to learn more) Not yet reviewed

Our Analysis

Personalized Deep Analysis

See exactly how this fits your health profile. What works for you, what doesn't, and whether you're getting your money's worth.

Unlock with Pro

Taking other supplements too?

Check your full stack for interactions, redundancies, and gaps. Takes 30 seconds.

Analyze My Stack
0 views