Under 250 mg a day
US adults average well under the 250 mg a day of EPA and DHA that health authorities suggest for heart health.
Peer-reviewed analysisEPA is the lead active here, studied most for triglycerides already in the normal range. Fish Oil is the most studied active here, with 15 human studies behind it, each one cited. Each serving carries 1,200 mg of EPA, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 4 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 1 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
Under 250 mg a day
US adults average well under the 250 mg a day of EPA and DHA that health authorities suggest for heart health.
Peer-reviewed analysis89% of US adults
aged 19 and over consumed more than the recommended 2,300 milligrams of sodium a day, in a CDC analysis of 2009 to 2012 dietary survey data.
CDC Morbidity and Mortality Weekly Report, 201457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics65.5% of US adults aged 20 to 64
had a blood cholesterol check by a health professional in the past 12 months in 2017, up from 58.0% in 2012, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2019Fewer than 1 in 5 US adults
know their cholesterol or blood sugar numbers, according to a national survey fielded for The Ohio State University Wexner Medical Center in December 2023.
SSRS Opinion Panel Omnibus for The Ohio State University Wexner Medical Center, 20239% of US women
and 5% of US men are getting the recommended daily amount of dietary fibre, based on National Health and Nutrition Examination Survey data collected from 2013 to 2018.
American Society for Nutrition, 202159 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Systematic review, 2020
Long-chain omega-3s including EPA lowered blood triglycerides by about 15% in a dose-dependent way, a reduction the review graded as high-certainty evidence.
Cochrane Database of Systematic ReviewsMeta-analysis, 2011
In trials giving DHA by itself, DHA lowered triglycerides and raised HDL cholesterol by about 4.5 mg/dL compared with placebo.
The paperMeta-analysis, 2025
Across 29 trials in 1,583 people, algae like chlorella cut top blood pressure by about 2.1 and bottom by about 1.9, with higher doses of whole algae working better.
Journal of Human Nutrition and DieteticsMeta-analysis, 2022
Across 71 trials, taking 2 to 3 grams a day of DHA and EPA together lowered the top blood pressure number by about 2.6 points.
Journal of the American Heart AssociationMeta-analysis, 2017
Across 51 trials in about 3,000 people, marine omega-3s lowered resting heart rate by about 2.2 beats per minute, an effect linked to DHA rather than EPA.
European Journal of Clinical NutritionMeta-analysis, 2023
Across 90 trials in 72,598 people, higher daily DHA and EPA intake lowered blood triglycerides and non-HDL cholesterol in a near-linear way, most clear above about 2 g a day.
Journal of the American Heart AssociationMeta-analysis, 2026
Pooling nine placebo-controlled eccentric-exercise trials in healthy adults, long-chain omega-3 fats reduced delayed onset muscle soreness (Hedges g -0.75) and the muscle-damage marker creatine kinase (-0.40) and improved muscle strength (0.45) and range of motion (0.93) at the point of worst impairment.
NutrientsMeta-analysis, 2014
EPA and DHA together lowered systolic blood pressure by about 1.5 mmHg and diastolic by about 1 mmHg, with a larger drop in people who started with higher blood pressure.
The paperMeta-analysis, 2026
Across 96 trials, EPA with DHA raised blood omega-3 levels and lowered several inflammation markers, with 1 to 3 grams a day the most consistent dose, all markers not outcomes.
Critical Reviews in Food Science and NutritionMeta-analysis, 2025
Across seven trials in 439 adults with elevated liver fat, fish oil moved triglycerides (standardised mean difference -0.40), the liver enzyme AST (-0.29), insulin resistance measured by HOMA-IR and waist circumference (-0.31) in a favourable direction, while ALT, GGT, body mass index and LDL cholesterol showed no detectable change.
Frontiers in NutritionRandomised trial, 2026
In 72 healthy adults given omega-3 for 12 weeks, krill oil raised blood omega-3 levels about 1.5 times more than fish oil.
The American Journal of Clinical NutritionRandomised trial, 2026
Using natural carbon isotope tracing in adults, this trial measured how long EPA, n-3 DPA and DHA persist in the body and how fast each turns over, giving direct human data on how the fatty acids accumulate with intake.
The American journal of clinical nutritionRandomised trial, 2026
In 26 amateur runners, 12 weeks of DHA and EPA raised red blood cell omega-3 levels while placebo stayed the same, blood markers not performance outcomes.
Prostaglandins, Leukotrienes and Essential Fatty AcidsRandomised trial, 2010
Formula-fed infants given DHA-enriched formula from 0.32% of fatty acids developed better visual acuity by 12 months than infants on DHA-free formula.
American Journal of Clinical NutritionRandomised trial, 2025
Infants whose mothers took a higher DHA dose during pregnancy differed on measures of visual attention during the first year, indicating a dose-related difference in early visual processing.
Developmental psychobiologyMeta-analysis, 2024
Pooling 9 randomised trials of DHA given before or after birth, infants in the DHA groups scored 1.47 points higher on the Psychomotor Development Index (95% CI 0.23 to 2.72), with no difference detected on the Mental Development Index.
Frontiers in NeurologyMeta-analysis, 2024
Pooling 15 trials in pregnant women, fish oil capsules showed no detectable difference from placebo in blood sugar or blood lipid measures overall, with a lower HOMA-IR (mean difference -0.60) in the subgroup taking under 200 mg of EPA.
Nutrition ReviewsMeta-analysis, 2021
Pooling 11 randomised trials of EPA and DHA taken during pregnancy or breastfeeding, the authors did not find consistent evidence of an effect on the children's measured cognitive outcomes or on birth weight.
Nutrition ReviewsRandomised trial, 2008
In 32 healthy adults taking DHA for two weeks, algal oil capsules and cooked salmon raised DHA about equally, about 80 percent and 25 percent in two blood measures.
Journal of the American Dietetic AssociationRandomised trial, 2014
In 16 men, after a high-fat meal 5 g of DHA lowered a blood marker of oxidative stress versus control, with no difference detected in fat clearance or vessel function.
The American Journal of Clinical NutritionRandomised trial, 2026
In 365 adults aged 55 to 80 with low dietary DHA, 2 g of DHA daily raised the spinal fluid DHA to arachidonic acid ratio at 6 months (difference 0.19, 95% CI 0.16 to 0.21), with no difference detected in brain volumes or cognitive scores over 24 months.
EBioMedicinePopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In the trial record, EPA in blood plasma plateaus after 4 to 8 weeks of daily fish oil, while EPA in the red blood cell membrane rises with a 28 day half-life and reaches a steady state at about 180 days.
In a randomised single-blind trial, 20 participants took either fish oil supplying 1,296 mg EPA and 864 mg DHA daily or flaxseed oil for eight weeks, with erythrocyte membrane and plasma samples drawn at weeks 0, 4, 8, 10, 12, 14, 16 and 24. On fish oil, erythrocyte membrane EPA rose 300 percent and DHA rose 42 percent by week eight. Levels held until about week 12 and then declined across the post-supplementation sampling, faster in plasma phospholipids than in erythrocyte membranes. Membrane fatty acid content was measured, not a symptom, and this is one trial of 20 people.
In a randomised double-blind crossover trial, healthy men and women aged 19 to 34 took capsules supplying about 4 g DHA per day, with plasma sampled at days 0, 1, 3, 7, 14 and 28. DHA concentrations tripled and so did DHA-derived oxylipins. Increases were detectable as early as day 1, and 11 of 12 individual DHA oxylipins plus total DHA oxylipins reached a plateau by days 5 to 7. The plateau came earlier and was reached by more oxylipins in females than in males. Plasma marker chemistry was measured, not a feeling.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Four ingredients, from each one's own page.
Membrane incorporation takes weeks. An omega-3 index blood test starts moving by about four weeks and settles across three to four months of daily use.
For the omega-3 index to settle at its new level. Triglyceride readings on a blood panel usually move sooner, inside four to eight weeks.
Membranes fill slowly. The omega 3 index moves over eight to twelve weeks, and the trials reporting cognitive or eye comfort changes run three to six months.
Red cell and plasma DHA climb over roughly eight to twelve weeks of daily use, then hold. It reads on an omega-3 index rather than as a sensation.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.