About 45% of US adults
take in less vitamin A than the estimated average requirement.
Peer-reviewed analysisVitamin E is the lead active here, studied most for oxidative stress defence. 15 human studies on Vitamin E back this formula, each one cited. Who it fits: skews toward women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 7 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Stronger in a pair".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 894 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 45% of US adults
take in less vitamin A than the estimated average requirement.
Peer-reviewed analysisAbout 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisAbout 84% of US adults
take in less vitamin E than the estimated average requirement.
Peer-reviewed analysisUnder 250 mg a day
US adults average well under the 250 mg a day of EPA and DHA that health authorities suggest for heart health.
Peer-reviewed analysis17.0% of US adults
reported binge drinking or heavy drinking in 2024, above the levels the low-risk guideline defines, in the Behavioral Risk Factor Surveillance System.
CDC Behavioral Risk Factor Surveillance System, 202454% of US adults
say they drink alcohol, matching the record low set the previous year, in Gallup's Consumption Habits survey.
Gallup, 2026US adults who drink average 3.2 drinks weekly
, down from an average of 3.9 drinks per week over prior years, in Gallup's Consumption Habits survey.
Gallup, 202613% of Dry January participants
say they plan to cut back on alcohol even after the month is over, in Numerator's research among US alcohol buyers.
Numerator, 202653.0% of calories
consumed by US adults age 19 and older came from ultra-processed foods, in NHANES data covering August 2021 to August 2023.
CDC National Center for Health Statistics, 202530.5% of US adults
slept less than 7 hours on average in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202618.1% of US adults
had trouble staying asleep on most days or every day in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2026US adults drank an average of 44 ounces
of plain water daily, in National Health and Nutrition Examination Survey data covering 2015 to 2018.
CDC, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2011
In trials giving DHA by itself, DHA lowered triglycerides and raised HDL cholesterol by about 4.5 mg/dL compared with placebo.
The paperMeta-analysis, 2022
Across 71 trials, omega-3 (DHA and EPA together) at 2 to 3 grams a day lowered the top blood pressure number by about 2.6 points.
Journal of the American Heart AssociationSystematic review, 2020
Long-chain omega-3s including EPA lowered blood triglycerides by about 15% in a dose-dependent way, a reduction the review graded as high-certainty evidence.
Cochrane Database of Systematic ReviewsRandomised trial, 2023
In 160 postmenopausal women with long-standing sleep difficulty, one month of vitamin E brought the median sleep questionnaire score to 6, versus 9 on placebo, where lower means better sleep.
NutrientsMeta-analysis, 2022
Across 8 trials in 1,002 women, vitamin E taken by mouth reduced reported menstrual cramp pain compared with placebo, with the clearest effect in the first month.
Clinical Nutrition ESPENMeta-analysis, 2026
In healthy adults after eccentric exercise, supplements combining EPA and DHA reduced muscle soreness across 9 placebo-controlled trials (Hedges g -0.75, 95% CI -1.14 to -0.36). The trials tested the two fats together rather than EPA alone.
NutrientsMeta-analysis, 2014
EPA and DHA together lowered systolic blood pressure by about 1.5 mmHg and diastolic by about 1 mmHg, with a larger drop in people who started with higher blood pressure.
The paperMeta-analysis, 2025
Across 21 trials, vitamin E lowered oxidized LDL and lengthened the time before LDL starts to oxidize, by about 20.45 units, both lab markers of oxidation.
European Journal of PharmacologyRandomised trial, 2001
In 120 adults with high blood cholesterol taking 15 mL of cod liver oil daily for 14 months, serum omega-3 fatty acids rose and plateaued by month 10 and whole-blood platelet clumping, a laboratory marker, was lower than in the no-supplement group, while total and HDL cholesterol did not change.
LipidsMeta-analysis, 2026
Across 96 trials, EPA with DHA raised blood omega-3 levels and lowered several inflammation markers, with 1 to 3 grams a day the most consistent dose, all markers not outcomes.
Critical Reviews in Food Science and NutritionMeta-analysis, 2026
A review re-examined trials of vitamin D against heart and blood vessel outcomes, questioning how they were analyzed and what the combined result actually supports.
European Journal of EpidemiologyMeta-analysis, 2014
Pooling 30 randomised trials in 5,615 adults averaging 61 years, vitamin D produced a small increase in overall muscle strength (standardised mean difference 0.17), with no detectable change in muscle mass or muscle power.
The Journal of Clinical Endocrinology and MetabolismMeta-analysis, 2023
Across 12 trials in 794 adults with high liver fat, at least 400 IU of vitamin E daily lowered two liver enzyme markers by 7 to 10 and 5 units.
NutrientsRandomised trial, 2026
In 72 healthy adults given omega-3 for 12 weeks, krill oil raised blood omega-3 levels about 1.5 times more than fish oil.
The American Journal of Clinical NutritionRandomised trial, 2026
In 26 amateur runners, 12 weeks of DHA and EPA raised red blood cell omega-3 levels while placebo stayed the same, blood markers not performance outcomes.
Prostaglandins, Leukotrienes and Essential Fatty AcidsMeta-analysis, 2015
Across 12 trials, vitamin E lowered a blood marker of inflammation by about 0.62 mg/l compared with not taking it.
European Journal of Clinical NutritionRandomised trial, 2026
In 365 adults aged 55 to 80 with low dietary DHA, 2 g of DHA daily raised the spinal fluid DHA to arachidonic acid ratio at 6 months (difference 0.19, 95% CI 0.16 to 0.21), with no difference detected in brain volumes or cognitive scores over 24 months.
EBioMedicineMeta-analysis, 2026
A review of reviews found vitamin D lowered blood inflammation markers, generally by a small amount.
InflammopharmacologyMeta-analysis, 2022
Across 13 randomised trials in women after midlife, vitamin D raised handgrip strength by about 0.88 kg, while a timed get-up-and-go mobility test showed no detectable difference.
Frontiers in EndocrinologySystematic review, 2022
Across 13 randomised trials in adults carrying several metabolic risk factors, vitamin D raised serum 25-hydroxyvitamin D levels and lowered fasting blood sugar, fasting insulin and an insulin-resistance index, with no detectable change in cholesterol or triglycerides. The authors call the overall picture inconclusive.
Frontiers in PharmacologyRandomised trial, 2022
In a winter trial of about 34,000 Norwegian adults taking cod liver oil for a median of 164 days, no reduction in reported acute respiratory infections was detected versus placebo (relative risk 1.04, 95% CI 0.97 to 1.11), and only low-grade side effects were reported.
BMJRandomised trial, 2010
Formula-fed infants given DHA-enriched formula from 0.32% of fatty acids developed better visual acuity by 12 months than infants on DHA-free formula.
American Journal of Clinical NutritionMeta-analysis, 2024
Pooling 9 randomised trials of DHA given before or after birth, infants in the DHA groups scored 1.47 points higher on the Psychomotor Development Index (95% CI 0.23 to 2.72), with no difference detected on the Mental Development Index.
Frontiers in NeurologyMeta-analysis, 2026
Pooling the available trials, adjuvant vitamin E alongside varicocele surgery was associated with better post-operative semen parameters, which are laboratory markers of sperm quality and not fertility outcomes.
Archivio Italiano di Urologia e AndrologiaMeta-analysis, 2026
A review combined trials of vitamin D given to adults in intensive care and looked at survival, though the trials varied widely in dose, route and starting vitamin D status.
Frontiers in NutritionMeta-analysis, 2021
Pooling 11 randomised trials of EPA and DHA taken during pregnancy or breastfeeding, the authors did not find consistent evidence of an effect on the children's measured cognitive outcomes or on birth weight.
Nutrition ReviewsRandomised trial, 2008
Over nine months, 39 percent of adults taking 10 g of cod liver oil daily reduced their anti-inflammatory medication use by more than 30 percent, versus 10 percent on placebo.
RheumatologyPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.
In a 3-phase crossover using two deuterium-labelled forms of alpha-tocopherol, healthy women absorbed about 55 percent of an oral dose taken with a 40 percent fat meal and about 64 percent with a fat-free meal, with samples tracked over 72 hours. The authors conclude absorption is not limited by absent fat or fasting, and that vitamin E leaves the intestine by a prolonged process.
In the trial record, EPA in blood plasma plateaus after 4 to 8 weeks of daily fish oil, while EPA in the red blood cell membrane rises with a 28 day half-life and reaches a steady state at about 180 days.
In a randomised single-blind trial, 20 participants took either fish oil supplying 1,296 mg EPA and 864 mg DHA daily or flaxseed oil for eight weeks, with erythrocyte membrane and plasma samples drawn at weeks 0, 4, 8, 10, 12, 14, 16 and 24. On fish oil, erythrocyte membrane EPA rose 300 percent and DHA rose 42 percent by week eight. Levels held until about week 12 and then declined across the post-supplementation sampling, faster in plasma phospholipids than in erythrocyte membranes. Membrane fatty acid content was measured, not a symptom, and this is one trial of 20 people.
In a randomised double-blind crossover trial, healthy men and women aged 19 to 34 took capsules supplying about 4 g DHA per day, with plasma sampled at days 0, 1, 3, 7, 14 and 28. DHA concentrations tripled and so did DHA-derived oxylipins. Increases were detectable as early as day 1, and 11 of 12 individual DHA oxylipins plus total DHA oxylipins reached a plateau by days 5 to 7. The plateau came earlier and was reached by more oxylipins in females than in males. Plasma marker chemistry was measured, not a feeling.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Six ingredients, from each one's own page.
Weeks to months. Liver stores buffer intake, so vitamin A status moves slowly and shows up on a blood panel rather than as a sensation.
25-hydroxyvitamin D climbs steadily over six to twelve weeks of daily use. That blood measurement is where the change shows up, rather than in a day-one sensation.
Plasma alpha-tocopherol climbs within days of daily intake, and anything you'd notice in skin condition is a slow change across a couple of months.
Omega-3 index and vitamin D readings shift over about eight to twelve weeks of daily use. Where joint comfort changes, it moves on a similar timeline.
For the omega-3 index to settle at its new level. Triglyceride readings on a blood panel usually move sooner, inside four to eight weeks.
Membranes fill slowly. The omega 3 index moves over eight to twelve weeks, and the trials reporting cognitive or eye comfort changes run three to six months.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.