Digest Gold.

40% of US adults

aged 18 and over report they experience bloating at least a few times a month, with 5% saying they experience it daily, per a 2023 Ipsos poll conducted for MDVIP.

34% of US adults

aged 18 and over report they experience abdominal discomfort or pain at least a few times per month, with women about twice as likely as men to report it several times weekly, per a 2023 Ipsos poll conducted for MDVIP.

28% of US adults

aged 18 and over say that digestive issues impact the quality of their life, a share that rises to about a third among those aged 18 to 44, per a 2023 Ipsos poll conducted for MDVIP.

32% of US adults

say they actively try to consume probiotics, and among them 60% try to do so at least once a day, per a 2022 IFIC survey on gut health.

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

61% to 74%

About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.

Meta-analysis, 2016

Across 34 trials in 2,028 adults, magnesium at about 368 mg daily for three months lowered systolic and diastolic pressure by about 2.0 and 1.8 points versus placebo.

Meta-analysis, 2025

Across 38 trials in 2,709 adults, magnesium lowered systolic pressure by about 2.8 points and diastolic by about 2.1 points, with no clear change in normal readings.

Meta-analysis, 2025

In a dose-response meta-analysis of trials in adults, magnesium raised HDL cholesterol by about 1.2 mg/dL, and no difference was detected in total cholesterol, triglycerides or LDL cholesterol.

Systematic review and meta-analysis, 2024

Improved flow-mediated dilation, a measure of how well arteries widen, by about 1.45 percentage points across 12 randomized trials.

Randomised trial, 2023

Healthy adults under everyday stress who took a standardised ashwagandha root extract reported lower perceived stress and tension scores and better self rated quality of life than those on placebo.

Meta-analysis, 2026

A combined review of trials found CoQ10 may ease low mood and fatigue scores on rating scales, though the trial set was small, with the usual review limits.

Meta-analysis, 2025

A second, overlapping combined review of the same CoQ10 trials reported similar effects on mood and anxiety scores, but it draws on the same studies rather than new evidence.

Controlled clinical trial, 1989

In 10 adults with poor lactose digestion, a lactase tablet gave average breath hydrogen of 29 parts per million versus 33 for plain milk, a smaller drop than other methods.

Randomised trial, 1985

In adults who malabsorb lactose, adding 2 g of one lactase to milk cut breath hydrogen down near the level of pre-split milk, while another lactase source worked less well.

Randomised trial, 2025

In 38 adults aged 65 to 75 doing eight weeks of interval training, CoQ10 improved chair-stand scores more than placebo, but grip, balance and walking speed did not differ.

Randomised trial, 2017

Oral adenosine 5' triphosphate raised post exercise blood ATP levels and increased measured muscle excitability compared with placebo.

Randomised trial, 1996

In 10 adults, adding microbial phytase from Aspergillus niger to a wheat bran meal raised iron absorption from 14.3 percent to 26.1 percent, while native wheat phytase made no difference.

Meta-analysis, 2026

A combined review across eight reviews found CoQ10 lowered fasting blood sugar by about 5.0 mg/dL and HbA1c by 0.17 percent in adults with high blood sugar, though results varied.

Systematic review, 2013

In human iron and zinc studies, phytase from Aspergillus niger raised iron and zinc absorption from phytate-rich foods, with 20 to 320 units per 100 g flour enough to help.

Meta-analysis, 2024

Coenzyme Q10 was linked to better semen quality measures like sperm count and movement, with a smaller rise in testosterone, across pooled trials in men.

Randomised trial, 2007

In 8 healthy volunteers eating a bean-rich test meal, 1200 GalU of the enzyme reduced breath hydrogen and the severity of flatulence, and both tested doses lowered the total symptom score.

Randomised trial, 1993

In adults who digest lactose poorly, microbial lactase preparations taken with milk containing 20 g of lactose cut peak and total breath hydrogen and made bloating and cramping milder, while with a 50 g lactose load the same 3,000 to 6,000 IU doses gave only a modest reduction the study could not distinguish from no change.

Randomised trial, 2014

In young adults eating zinc-fortified maize porridge, phytase added just before eating or used to break down phytate during preparation raised fractional zinc absorption by more than 80 percent either way.

Systematic review, 2023

Across human trials of Withania somnifera, the review found generally favourable shifts in hormonal and biochemical markers including cortisol and testosterone, with study sizes small and extracts differing between trials.

Meta-analysis, 2025

Across 23 trials in 1,345 adults with elevated blood sugar, magnesium raised blood magnesium, lowered fasting blood sugar by about 0.58 mmol/L, and only slightly moved longer-term blood sugar control.

Randomised trial, 2003

In 46 healthy adults, magnesium citrate raised serum magnesium more than magnesium oxide or amino-acid chelate after both a single dose and 60 days of daily use, indicating higher absorption of the citrate form.

Randomised trial, 2026

Oral multienzyme supplementation was reported to alter postprandial plasma nutrient concentrations after a mixed meal in healthy adults. Amylase is one enzyme within the blend, and plasma nutrient concentrations are markers rather than clinical outcomes.

Systematic review, 2023

The review pooled trials of adaptogenic botanicals on low mood outcomes and concluded the evidence is heterogeneous and mostly from small studies, while setting out a rationale for combining them with physical activity.

Case-control, 2026

In adults with elevated liver fat, gene variants including one for a fat-processing enzyme were linked to liver measures, an association rather than a cause.

Randomised trial, 2019

In 26 children aged 18 to 23 months, adding phytase to a fortified porridge nearly doubled the zinc absorbed, from 0.5 mg to 1.1 mg.

Randomised trial, 2014

In 862 adults preparing for colonoscopy, a split-dose sodium picosulfate plus magnesium citrate regimen produced adequate bowel cleansing in 85.8% of people compared with 69.8% on the standard dosing schedule.

Cohort study, 2025

In a cohort comparison rather than a randomised trial, the authors report substituting invertase for a sacrosidase oral solution in children with reduced intestinal sucrase activity managed in one clinical service, and describe the substitution as workable at lower cost in that setting. A single-service cohort report with no randomisation and no control group, so it does not establish an effect.

Systematic review, 2024

A review of randomised trials found the evidence for lactase drops shortening infant crying was inconsistent, with the better-designed trials detecting no difference.

Meta-analysis, 2024

Pooling randomised trials of lactase drops in unsettled infants, the reviewers did not detect a clear reduction in crying time, and the trials were small and varied in method.