Agnuside is the lead active here, studied most for hormonal balance. Organic Chaste Tree (Vitex agnus-castus) berry extract is the most studied active here, with 7 human studies behind it, each one cited. Who it fits: made for women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 19 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
20% of US women
reported frequent fatigue, feeling very tired or exhausted most days or every day, compared with 13% of men, in the National Health Interview Survey.
CDC National Center for Health Statistics, 20261.57% of US men aged 50 to 64
were prescribed testosterone in 2025, the highest share of any age group, in an analysis of US health system records.
Epic Research, 202657.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics27.6% of US men aged 20 and older
had a total testosterone level below 300 nanograms per deciliter, consistent with falling testosterone with age, in an analysis of National Health and Nutrition Examination Survey records collected 2011 to 2016.
Frontiers in Endocrinology analysis of NHANES data, 202459 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2016
A Cochrane review of dietary supplements for period pain, chasteberry included, judged the evidence too low in quality to say whether menstrual discomfort improves.
The Cochrane database of systematic reviewsRandomised trial, 2006
In a placebo-controlled trial, a blend containing chasteberry was linked to higher mid-cycle progesterone and more normal-length cycles in women trying to conceive, though the effect can't be pinned on chasteberry.
Clinical and experimental obstetrics & gynecologyCohort study, 2025
A four-cycle single-arm observational study of a chasteberry-containing supplement reported lower premenstrual symptom scores over time, though with no placebo group the change cannot be attributed to the supplement.
Cohort studyOpen-label trial, 2023
A nutraceutical composition containing a vitex extract was assessed for efficacy and tolerability, and because the composition carried multiple ingredients the result cannot be attributed to vitex alone.
CureusMeta-analysis, 2020
A Cochrane review of oral galactagogues, chasteberry among the herbs assessed, found very low certainty evidence and no clear effect on breast milk volume.
The Cochrane database of systematic reviewsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Two ingredients, from each one's own page.
Two to three cycles. The axis it acts on runs monthly, so the readout is how one cycle compares with the ones before it.
Two to three full cycles. Little lands in the first weeks, and the change reads as a difference between one cycle and the next.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
