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Verified by IngredientMD/Legion Athletics/Whey+ Protein Isolate
VERIFIED BYingredientMD

Whey+ Protein Isolate.

Backed by human trialsLegion Athletics, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Legion Athletics.

Iron is the lead active here, studied most for oxygen delivery to working muscle. 17 human studies on Iron back this formula, each one cited. Who it fits: skews toward women, adults.

Clinically dosedFull label disclosure
5Active ingredientsWell studiedResearch base55Human studies
Whey+ Protein IsolateVerified by IngredientMD
Legion AthleticsIngredientMD
The verdict
Backed by human trials
For Skews toward women, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Calcium: Occasional muscle crampingExtensively studied
Iron: Oxygen delivery to working muscleKey driver
Sodium: EnduranceWell studied
Whey Protein Isolate: StrengthExtensively studied
Maltodextrin: EnduranceSupporting role
Visit the brand

How we read this product

Source: Supplement facts
Supplement Facts panel for Whey+ Protein Isolate
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 5 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
55
Human studies
0.83 mg
Iron
136 mg
Calcium
25 g per serving sits inside the studied 10 g-25 g range
Whey Protein Isolate, Morton et al. 2018 Br J Sports Med meta-analysis (49 RCTs); Jager et al. 2017 JISSN position stand.

Cross-checked against 1,918 documented interactions for these actives.

Read the evidenceCalcium, the evidence →Iron, the evidence →Sodium, the evidence →Whey Protein Isolate, the evidence →Maltodextrin, the evidence →

Inside the formula

Calcium
13 studies
Occasional muscle cramping
Extensively studied
Iron
17 studies
Oxygen delivery to working muscle
Key driver
Sodium
11 studies
Endurance
Well studied
Whey Protein Isolate
Strength
Extensively studied
Maltodextrin
Endurance
Supporting role
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2023

21.1% of the US population

aged 15 and over took part in sports, exercise, or recreation on an average day in 2023, in the American Time Use Survey.

US Bureau of Labor Statistics, 2024
This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
18 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Maltodextrin

Randomised trial, 2020

Maltodextrin taken during a resistance training session supplied carbohydrate to working muscle and altered the metabolic response to the session compared with placebo.

Journal of sports science & medicine
Whey Protein Isolate

Randomised trial, 2025

A leucine-enriched beta-lactoglobulin preparation was compared with an isonitrogenous whey protein isolate for skeletal muscle protein synthesis, a stable-isotope marker measured over hours rather than a change in muscle size.

Nutrients
Sodium

Randomised trial, 2026

Microencapsulated sodium butyrate was tested against abdominal symptom scores and carbohydrate metabolism markers in adults with high blood sugar. Again a butyrate trial in which sodium is the carrier salt.

Scientific Reports
Whey Protein Isolate

Systematic review, 2026

Across the trials reviewed, whey and soy protein supplementation alongside resistance training in young adults was associated with changes in training adaptations, with the authors noting variability between studies.

Journal of Dietary Supplements
Whey Protein Isolate

Systematic review, 2025

Supplementation with milk proteins was reviewed for effects on body composition and anthropometric measures, with results varying by the training and dietary context of the underlying trials.

Nutrients
Whey Protein Isolate

Systematic review, 2026

Long-term plant and animal protein supplementation were compared for body composition, muscle strength and physical performance. The review did not detect a clear separation between the two sources, which is a failure to detect a difference rather than evidence that they perform identically.

Frontiers in Nutrition
Whey Protein Isolate

Randomised trial, 2019

Whey protein isolate taken during endurance training did not produce a detectable change in cycling performance or the immune measures recorded, which is a failure to detect a difference and not evidence that none exists.

Frontiers in Nutrition
Sodium

Systematic review, 2026

A systematic review catalogued gastrointestinal symptoms reported across sodium bicarbonate dosing protocols and described how symptom burden varies with dose, timing and whether the dose is split or given with food.

European Journal of Sport Science
Maltodextrin

Randomised trial, 2026

A dietary fibre and counselling trial during weight management in which maltodextrin is named among the study preparations. The reported tolerability findings are not attributable to it.

Scientific Reports
Sodium

Randomised trial, 2026

A randomised trial tested an algorithm-driven sodium supplementation protocol against usual care and measured growth in infants born preterm.

Pediatrics Open Science
Sodium

Randomised trial, 2025

In a trial of 104 very preterm infants, oral sodium supplementation raised daily weight gain by 3.6 grams per kilogram compared with placebo.

BMJ Paediatrics Open

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people17 human studies on Iron back this formula, each one cited.
  • A mechanism that is settledHow Calcium and Iron work is settled pharmacology.
  • Studied together, not just separatelyCalcium and Iron have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2026.
  • Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
  • The exact form, describedThe label names its forms exactly: Calcium carbonate, Ferrous sulfate, Sodium chloride, table salt, sea salt. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeCalcium is made by mineral.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
  • Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.
Studied together

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

  • Sodium + MaltodextrinHydration

    In a randomized placebo-controlled trial in 26 athletes rehydrating after exercise, drinks containing sodium and carbohydrate retained about 74 to 77 percent of the fluid consumed over three and a half hours, compared with about 58 percent for plain water.

    Early

Research strength. Research strength says how much work stands behind the combination. It is never a product score.

Fail closed. Where actives were studied on their own rather than together, each shows on its own evidence, never a combined effect no trial measured.

Independent record. Every finding is cited to a named trial, dated, and never written by the brand.

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Calciumwithin about one to six hours of a single doseMeasured within a day

    A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.

    Promising
  • Ironwithin 24 hours of a single doseMeasured within a day

    A randomised crossover study in 54 nonanemic young women with plasma ferritin at or below 20 ug/L gave labelled iron sulfate as single fasting morning doses of 40, 60, 80, 160 and 240 mg. Twenty four hours after doses of 60 mg or more, serum hepcidin was raised and fractional iron absorption from the following dose was 35% to 45% lower. Across the dose range a sixfold rise in dose, 40 to 240 mg, produced a threefold rise in iron absorbed, 6.7 to 18.1 mg. Total iron absorbed from three doses inside 24 hours was not significantly greater than from two morning doses. The measure was iron absorption and serum hepcidin, not a symptom.

    Promising
  • Sodiumabout 3 days to 4 weeks of steady intakeBuilds with daily use

    In the excretion studies the EFSA reference opinion reviews, urinary output closely tracked dietary sodium once intake was held steady: 98% of dietary sodium appeared in 24-hour urine in a 3-day study, and 86% of sodium ingested over 4 weeks was recovered in 24-hour urine collected during the same period.

    Early
  • Sodiumabout 29 days at each fixed intake levelBuilds with daily use

    In the controlled metabolic study the EFSA reference opinion reviews, young men held at constant sodium intakes for 29 days per level showed rising average daily urinary aldosterone excretion as intake was stepped down from 4.9 g/day to 2.5 g/day.

    Promising
  • Whey Protein Isolatewithin 30 minutes of a doseMeasured within a day

    In a randomised crossover trial, 12 healthy men aged 19 to 32 consumed 29.6 g of whey protein isolate, with plasma amino acids sampled at 30, 60, 90, 120 and 180 minutes after the dose. Essential amino acids, branched-chain amino acids and leucine all rose significantly from baseline in both arms. The trial's comparison was between a processed isolate and the standard form.

    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

Five ingredients, from each one's own page.

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Format

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.

Best forGram-scale actives: creatine, collagen, protein, electrolytes, beta-alanine.
From the same shelf

Studied alongside this brand's other formulas

Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.

Legion Pulse Pre-Workout + Whey+ Protein IsolateEstablished

Caffeine modestly raises the amount of calcium passed in urine and slightly lowers how much the gut takes up, so keeping calcium intake adequate helps hold normal calcium balance. The effect per serving is small and easily offset by sufficient intake.

Established mineral pharmacology. No combination trial has tested this exact pairing.

Legion Recharge Post-Workout + Whey+ Protein IsolateEstablished

The two hydroxylases in the carnitine pathway are iron dependent enzymes that also need ascorbate to keep the iron in its active state. Iron status is part of the same requirement.

cofactor for carnitine biosynthesis. No combination trial has tested this exact pairing.

Whey+ Protein Isolate
Available from Legion Athletics
Backed by human trialsVerified Oct 2026
View at Legion Athletics

Questions shoppers ask

Is Whey+ Protein Isolate independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Whey+ Protein Isolate?
Whey+ Protein Isolate is built on Calcium, Iron, Sodium, Whey Protein Isolate, Maltodextrin. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 1,918 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

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