49.1% of US adults
aged 20 and over tried to lose weight in the past 12 months, in the National Health and Nutrition Examination Survey fielded from 2013 to 2016.
CDC National Center for Health Statistics, 2018Alpha Lipoic Acid is the lead active here, studied most for healthy glucose metabolism. 16 human studies on Alpha Lipoic Acid back this formula, each one cited. Each serving carries 600 mg of Alpha Lipoic Acid, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 2 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
49.1% of US adults
aged 20 and over tried to lose weight in the past 12 months, in the National Health and Nutrition Examination Survey fielded from 2013 to 2016.
CDC National Center for Health Statistics, 201815% of US adults
reported following a calorie-counting eating pattern in the past year, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202675% of US adults
said they were trying to limit or avoid sugar in their diet, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202657.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics47% of US adults
aged 20 and over kept added sugars under the Dietary Guidelines limit of 10 percent of daily calories, leaving more than half of US adults over that limit, in the What We Eat in America dietary recall component of NHANES 2015-2016.
USDA Agricultural Research Service, Food Surveys Research Group, 201995% of US adults
aged 20 and over ate one or more snacks on the day their diet was recorded, in the What We Eat in America dietary recall component of NHANES 2017 through March 2020.
USDA Agricultural Research Service, Food Surveys Research Group, 202459 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2020
Across 18 trials, alpha-lipoic acid lowered body weight by about 2.3 kg, and across 21 trials it lowered BMI by about 0.5 kg/m2.
International Journal of Clinical PracticeMeta-analysis, 2026
Across 63 trials, alpha-lipoic acid lowered fasting blood glucose by about 5.3 mg/dL and body weight by about 0.6 kg, with no detectable change in blood pressure or LDL.
Nutrition, Metabolism and Cardiovascular DiseasesMeta-analysis, 2018
Across 24 trials in people with metabolic conditions, alpha-lipoic acid was linked to lower fasting glucose, with a standardized effect of -0.54, plus lower insulin resistance, triglycerides and LDL cholesterol.
MetabolismMeta-analysis, 2018
Across 18 trials in adults with metabolic conditions, alpha-lipoic acid was linked to lower levels of an inflammation marker, with an effect size of -1.52, plus two related inflammation markers.
Nutrition & MetabolismRandomised trial, 2022
Curcumin taken together with piperine raised blood vitamin D levels compared with placebo in the women studied.
BMC complementary medicine and therapiesMeta-analysis, 2024
Across 10 trials in 529 participants, alpha-lipoic acid showed no detectable effect on the blood markers ferritin, serum iron, haemoglobin or total iron binding capacity, with a higher haemoglobin reading only in longer trials and selected subgroups.
International Journal for Vitamin and Nutrition ResearchMeta-analysis, 2025
Pooling five randomised trials in 250 men, alpha-lipoic acid raised total sperm motility by about 13 percentage points and progressive motility by about 12, while sperm concentration and semen volume showed no detectable change.
International Brazilian Journal of UrologyPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In an open-label randomized crossover study, 24 healthy adults took single 600 mg doses of racemic alpha-lipoic acid in different oral forms, and both enantiomers were absorbed rapidly, with median time to peak plasma concentration between 0.33 and 0.5 hours and blood sampling complete by 8 hours.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
Marker changes build over four to twelve weeks of daily use. Studies measuring nerve comfort in hands and feet typically read out at around five weeks.
There is nothing to time on its own. Piperine changes how much of its partner compound reaches your blood, so the timeline you watch is that partner's.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
A 50:50 mixture of the R and S enantiomers of lipoic acid, sold as the free acid. The same molecule is also labelled thioctic acid.
In an open-label four-way crossover in 24 adults, a racemic solution produced higher peak plasma concentrations of both enantiomers than the 200, 300, and 600 mg tablet forms.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.