Milk Thistle Extract is the lead active here. 5 human studies on Milk Thistle Extract back this formula, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 3 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 18 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
17.0% of US adults
reported binge drinking or heavy drinking in 2024, above the levels the low-risk guideline defines, in the Behavioral Risk Factor Surveillance System.
CDC Behavioral Risk Factor Surveillance System, 202454% of US adults
say they drink alcohol, matching the record low set the previous year, in Gallup's Consumption Habits survey.
Gallup, 2026US adults who drink average 3.2 drinks weekly
, down from an average of 3.9 drinks per week over prior years, in Gallup's Consumption Habits survey.
Gallup, 202613% of Dry January participants
say they plan to cut back on alcohol even after the month is over, in Numerator's research among US alcohol buyers.
Numerator, 202653.0% of calories
consumed by US adults age 19 and older came from ultra-processed foods, in NHANES data covering August 2021 to August 2023.
CDC National Center for Health Statistics, 202530.5% of US adults
slept less than 7 hours on average in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202618.1% of US adults
had trouble staying asleep on most days or every day in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2026US adults drank an average of 44 ounces
of plain water daily, in National Health and Nutrition Examination Survey data covering 2015 to 2018.
CDC, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Randomised trial, 2020
Artichoke (Cynara) supplementation improved fasting blood sugar and blood lipid measures in adults with excess body weight and newly detected raised fasting glucose.
NutrientsMeta-analysis, 2025
Comparing interventions for elevated liver fat, lifestyle change ranked ahead of supplement options, with silymarin among the supplements showing smaller improvements in liver measures.
Asia Pacific journal of clinical nutritionRandomised trial, 2019
A supplement supplying chlorogenic acid and luteolin improved liver and cardiometabolic measures in adults with elevated liver fat compared with placebo.
NutrientsSystematic review, 2019
A review found foods and supplements rich in compounds like chlorogenic acid moved several heart and metabolic markers modestly, with results varying between trials.
NutrientsMeta-analysis, 2025
Pooling silymarin trials, the review found liver enzyme readings improved on average and that the size of the change tracked with the dose and the length of use.
BMC complementary medicine and therapiesMeta-analysis, 2022
In adults with elevated liver fat, a class of polyphenol supplements that included silymarin lowered circulating ALT and AST compared with control, with tolerability similar to control.
Frontiers in immunologyRandomised trial, 2023
A combination of chlorogenic acid and luteolin was linked to better metabolic lab measures in adults with excess weight, an effect of the pair.
NutrientsOpen-label trial, 2009
A small, uncontrolled single-day study of a dandelion leaf extract reported more urinary output after dosing, described by the authors as a pilot with no control group.
Journal of Alternative and Complementary MedicinePopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Three ingredients, from each one's own page.
There's no same-day sensation. Liver enzyme readings are where change shows, and the trials that saw movement ran eight to twelve weeks of daily use.
Bitterness registers at the meal itself. Fermentation of the root's fructans starts inside a day, and steadier digestive comfort builds over one to two weeks of daily use.
The bitter, secretion-prompting side works around the meal you take it with. Lipid panel changes in trials show up over six to eight weeks of daily use.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
