N-Acetyl Cysteine is the lead active here, studied most for glutathione status. Selenium is the most studied active here, with 15 human studies behind it, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 948 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
17.0% of US adults
reported binge drinking or heavy drinking in 2024, above the levels the low-risk guideline defines, in the Behavioral Risk Factor Surveillance System.
CDC Behavioral Risk Factor Surveillance System, 202454% of US adults
say they drink alcohol, matching the record low set the previous year, in Gallup's Consumption Habits survey.
Gallup, 2026US adults who drink average 3.2 drinks weekly
, down from an average of 3.9 drinks per week over prior years, in Gallup's Consumption Habits survey.
Gallup, 202613% of Dry January participants
say they plan to cut back on alcohol even after the month is over, in Numerator's research among US alcohol buyers.
Numerator, 202653.0% of calories
consumed by US adults age 19 and older came from ultra-processed foods, in NHANES data covering August 2021 to August 2023.
CDC National Center for Health Statistics, 202530.5% of US adults
slept less than 7 hours on average in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202618.1% of US adults
had trouble staying asleep on most days or every day in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2026US adults drank an average of 44 ounces
of plain water daily, in National Health and Nutrition Examination Survey data covering 2015 to 2018.
CDC, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Randomised trial, 2024
In a pilot trial in 165 adults with low vitamin D, adding L-cysteine to vitamin D for 6 months raised usable vitamin D levels and lowered inflammation markers compared with vitamin D alone.
BMJ Nutrition, Prevention and HealthRandomised trial, 2025
Antioxidant supplementation with N-acetylcysteine was assessed against seminal parameters. The reported outcomes are semen analysis measures rather than clinical endpoints.
Archivio Italiano di Urologia e AndrologiaRandomised trial, 2020
In a small crossover trial in 19 healthy men given alcohol, 1,200 mg of L-cysteine was linked to less next-day nausea and headache, and 600 mg to lower stress and anxiety, on correlational analysis.
Alcohol and AlcoholismRandomised trial, 2019
N-acetylcysteine supplementation was linked to changes in sperm quality, chromatin integrity and oxidative stress markers, laboratory semen and marker measures.
Reproductive Biology and EndocrinologyRandomised trial, 2019
N-acetylcysteine supplementation was associated with changes in functional connectivity measured by neuroimaging within the cingulate cortex. A brain imaging marker, not a symptom or functional outcome.
International Journal of NeuropsychopharmacologyRandomised trial, 2022
Selenium, N-acetylcysteine, or both were compared against thyroid hormone marker changes in adults receiving haemodialysis. The endpoints are circulating markers, not clinical outcomes.
PharmacologyPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a 12 week randomised double-blind placebo-controlled trial in 119 healthy UK adults aged 50 to 64, mean plasma selenium rose from 95.7 ng/mL at baseline to steady state by week 10, reaching 118.3, 152.0 and 177.4 ng/mL on 50, 100 and 200 micrograms a day of selenium-enriched yeast. Plasma selenoprotein P rose in every selenium arm. Platelet glutathione peroxidase activity did not change significantly at any dose or form.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
No felt onset. Plasma selenium and glutathione peroxidase activity rise over three to six weeks of daily intake and then plateau once the enzyme pool is filled.
Nothing on day one. Glutathione and oxidation markers in trials shifted over roughly two to four weeks of steady daily intake.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
The free amino acid with an unprotected thiol group, a white crystalline solid.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
