12% of US adults
regularly reported feelings of worry, nervousness, and anxiety in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 2024L-Theanine is the lead active here, studied most for calm and steady mood. 14 human studies on L-Theanine back this formula, each one cited. Each serving carries 100 mg of L-Theanine, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 746 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
12% of US adults
regularly reported feelings of worry, nervousness, and anxiety in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202439% of adults worldwide
said they worried a lot the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.
Gallup, 202437% of adults worldwide
said they felt stressed the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.
Gallup, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Randomised trial, 2024
Over 28 days, 15 healthy adults with moderate stress taking a branded L-theanine ingredient had perceived-stress scores fall 17.98%, alongside routine safety monitoring.
Neurology and TherapyRandomised trial, 2025
Over five days, 15 young women with menstrual discomfort drinking a chamomile and theanine beverage had self-reported pain ratings fall 57.17%, with mood and sleep ratings also changing.
Journal of Food and Drug AnalysisSystematic review, 2020
Across 9 trials, 200 to 400 mg a day of L-theanine may help lower stress and anxious feelings in people facing stressful situations.
Plant Foods for Human NutritionRandomised trial, 2019
In a 4-week trial in 30 healthy adults, 200 mg a day of L-theanine improved sleep quality scores, with faster sleep onset and less disturbance.
NutrientsMeta-analysis, 2025
In healthy adults, across trials, L-theanine with caffeine modestly improved accuracy on an attention-switching task, and L-theanine alone modestly sped up choice reaction time.
Nutrition ReviewsMeta-analysis, 2018
Pooling ten trials each, caffeine produced a small increase in maximal muscle strength (SMD 0.20) and in muscle power measured by vertical jump (SMD 0.17) compared with placebo.
Journal of the International Society of Sports NutritionRandomised trial, 2026
In 38 active men, caffeine before a 10 km run or 40 km cycling improved completion time by 1.8 percent, though a gene difference in caffeine levels didn't affect performance.
European Journal of Sport ScienceSystematic review, 2019
Across 10 studies at matched doses, caffeine gave similar aerobic and fatigue benefits to men and women, while 4 of 7 studies found bigger strength and sprint gains in men.
NutrientsMeta-analysis, 2022
Across 21 trials at 3 to 9 mg per kg, caffeine lengthened time to exhaustion in running and shortened race completion time compared with placebo.
NutrientsSystematic review, 2021
Across 37 blinded crossover studies, caffeinated drinks improved several aspects of sports performance once the drink supplied at least 3 mg of caffeine per kg of body mass.
NutrientsSystematic review, 2010
In a Cochrane review of 13 randomized trials in shift workers, caffeine improved orientation and attention (SMD -0.55) and reduced the number of errors made during simulated night or shifted work versus placebo.
Cochrane Database of Systematic ReviewsMeta-analysis, 2025
Pooling the randomised trials, L-theanine was linked to small improvements in self-reported sleep quality, while objective sleep measures showed no detectable difference.
Meta-analysisPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a double-blind placebo-controlled crossover trial, 15 resistance-trained women took 4 mg per kg body mass of caffeine 60 minutes before a strength and power battery. Squat one-repetition maximum rose 4.5 percent and countermovement jump height 7.6 percent against placebo. A separate crossover trial in 11 active adults began its cycling tests 45 minutes after a 3 mg per kg capsule and recorded a peak-power increase of about 4 percent on the first day of ingestion.
One crossover trial mapped the day-to-day time course in 11 healthy active adults taking 3 mg per kg per day for 20 consecutive days. Peak cycling power in the incremental test stayed about 4.0 percent above placebo for the first 15 days and the difference then lessened. Wingate peak power was still raised on days 1, 4, 15 and 18 by about 4.9 percent. The authors describe the shrinking margin as progressive tolerance. This is one trial with 11 participants.
Two double-blind placebo-controlled crossover trials measured attention at a fixed interval after one oral dose. In 24 overnight sleep-deprived adults aged 20 to 25, a 200 mg dose tested 45 minutes post-dose reduced false alarms on a traffic-scene recognition task and raised target-distractor discriminability. In 27 healthy young adults tested 50 minutes post-dose, 400 mg shortened the parietal P3b event-related potential latency against placebo, with no significant change at 100 or 200 mg. Both trials measured task and electrophysiological markers, not a subjective feeling.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
Fifteen to forty five minutes for most people, peaking around the hour. How long it lasts depends on liver enzyme activity and varies several fold between people.
For most people, with blood levels peaking inside the first hour. Nothing accumulates, so each dose stands on its own.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
Dry crystalline free base with no water of crystallisation, close to a hundred percent caffeine by weight
The single L-enantiomer as a free amino acid, the form found in tea leaf and the form used in essentially all human trials.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.