About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisElderberry Fruit Powder is the lead active here, studied most for immune resilience. Zinc is the most studied active here, with 22 human studies behind it, each one cited. Each serving carries 11 mg of Zinc, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 5 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 940 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisAbout 15% of US adults
take in less zinc than the estimated average requirement.
Peer-reviewed analysis15% of US adults
had a usual zinc intake below the Estimated Average Requirement, up from 11% in an earlier survey period, across NHANES data from 2005 to 2016.
Peer-reviewed NHANES analysis, 202057.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics30% of US supplement users
name immune health as a reason they take a supplement, second only to general health and wellness, in the Council for Responsible Nutrition's 2024 Consumer Survey.
Council for Responsible Nutrition, 202460.2% of US adults age 20 and over
took a dietary supplement of any kind in the past 30 days, with use higher among women at 66.1% than men at 53.9%, in NHANES data covering August 2021 to August 2023.
CDC National Center for Health Statistics, 202446% of US adults
had a usual vitamin C intake below the Estimated Average Requirement from food alone, falling to 33% once supplement intake is counted, across NHANES data from 2005 to 2016.
Peer-reviewed NHANES analysis, 202043.5% of employed US women
and 37.0% of employed US men aged 18 and over missed at least one day of work in the past 12 months because of illness or injury, in the 2017 National Health Interview Survey.
CDC National Center for Health Statistics, 201948% of US adults
admit they forget or choose not to wash their hands at key moments, and one in five say they actively choose not to, in the 2025 State of Handwashing Report.
National Foundation for Infectious Diseases, 202530.5% of US adults
slept less than 7 hours on average in a 24 hour period in 2024, short of the amount the American Academy of Sleep Medicine recommends, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202559 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2016
Zinc acetate lozenges cut cold symptom length by about 2.7 days, versus a roughly seven day average, across three pooled trials.
British Journal of Clinical PharmacologyMeta-analysis, 2019
Across trials in 180 people, elderberry was linked to shorter and milder upper airway symptoms, with a large average effect.
Complementary Therapies in MedicineRandomised trial, 2013
In a multidose placebo-controlled study, larch arabinogalactan altered blood immune cell and cytokine measures in healthy adults, with the response differing by dose.
Journal of the American College of NutritionRandomised trial, 2026
Daily baker's yeast beta-1,3/1,6-glucan raised markers of mucosal immune activity in the upper airway of healthy adults compared with placebo.
NutrientsRandomised trial, 2012
Twelve weeks of baker's yeast beta-glucan reduced self-reported upper respiratory symptom days and improved mood scores in women under stress.
Journal of the American College of NutritionSystematic review, 2021
The authors pooled the available elderberry trials for upper respiratory symptoms and concluded the evidence is limited, the trials small and the certainty low, with some reporting shorter symptom duration.
BMC Complementary Medicine and TherapiesRandomised trial, 2010
A proprietary arabinogalactan extract raised the measured antibody response to a pneumococcal vaccine compared with placebo in healthy adults.
Nutrition journalRandomised trial, 2013
Beta-glucan from baker's yeast raised salivary IgA, an antibody in saliva, and lowered reported symptom days in adults after a hard exercise bout.
Journal of dietary supplementsRandomised trial, 2013
Taking baker's yeast beta-glucan was followed by higher immune cell counts and signaling markers in the blood after exercise, which are lab markers, not health outcomes.
British Journal of NutritionRandomised trial, 2013
The authors reported fewer self-reported episodes of upper respiratory symptoms in the larch arabinogalactan group than in placebo over the supplementation period.
Current medical research and opinionRandomised trial, 2016
The authors reported shorter symptom duration and lower symptom scores in the elderberry arm compared with placebo among long-haul air travellers.
NutrientsRandomised trial, 2025
In ten adults with excess weight, a week of twice-daily elderberry juice shifted activity in 234 genes versus 59 on placebo, a gene-activity signal rather than a measured outcome.
NutrientsRandomised trial, 2020
In this double-blind placebo-controlled trial the investigators did not detect a difference in symptom duration between elderberry extract and placebo. A failure to detect a difference is not a demonstration that none exists.
Journal of General Internal MedicineMeta-analysis, 2024
Across six trials in 739 women, zinc lowered menstrual discomfort scores, with bigger drops after eight weeks or more, even at doses as low as 7 mg daily.
NutrientsMeta-analysis, 2025
Across four trials in women of reproductive age, zinc lowered premenstrual symptom scores, with the biggest gain in mood and a smaller, less certain gain in physical symptoms.
Women and HealthRandomised trial, 2024
Yeast beta-glucan supplementation lowered insulin resistance readings, a blood marker, without changing the make-up of the gut bacteria.
The British journal of nutritionRandomised trial, 2024
In a crossover trial of 18 overweight adults, one week of elderberry juice lowered post-meal blood glucose and raised fat oxidation during and after a meal test.
NutrientsMeta-analysis, 2026
Pooling randomised trials in adults, zinc had a small effect on body weight and waist circumference and no detectable effect on body mass index, fat mass, fat-free mass or adipokine levels, and the authors call the size of the changes minor.
Biological Trace Element ResearchRandomised trial, 2004
Long-term arabinogalactan supplementation showed no detectable change in serum lipids or glucose in the participants studied.
Journal of the American Dietetic AssociationSystematic review and meta-analysis, 2016
In children older than six months, zinc may shorten a bout of diarrhea by about half a day across nine trials, on low certainty evidence.
Cochrane Database of Systematic ReviewsMeta-analysis, 2011
Across 36 studies in children under five, zinc modestly increased height growth, adding roughly 0.37 cm at about 10 mg a day for 24 weeks.
BMC Public HealthPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.
Across three randomised placebo-controlled trials pooled as individual patient data (199 adults with naturally acquired colds, 80 to 92 mg of elemental zinc a day as acetate lozenges), 70 percent of the zinc group had recovered by day 5 against 27 percent on placebo, and colds ran 2.73 days shorter against a 7 day average duration. A separate meta-analysis of seven lozenge trials (575 participants, doses above 75 mg a day, zinc acetate or zinc gluconate) measured cold duration 33 percent shorter, with no significant difference between the two salts.
In a controlled feeding study in nine healthy men, six weeks of restricted zinc intake raised DNA strand breaks in peripheral blood cells, and four weeks of repletion at 11 mg a day, with 20 mg of supplemental zinc for the first seven days, reversed the rise. In a separate randomised placebo-controlled trial in 40 Ethiopian women eating a high-phytate diet, 20 mg a day of zinc sulfate for 17 days lowered mean comet tail moment from 39.7 to 30.0 while plasma zinc did not change significantly. Both windows were measured on a DNA damage marker in blood cells, not on a symptom.
In a kinetic study, 6 healthy volunteers took a single 30 ml oral dose of elderberry extract providing 147.3 mg of anthocyanins. The anthocyanins appeared in plasma and were excreted in urine within 7 hours, with a plasma half-life of about 1.74 hours.
In a randomised crossover trial, adults with overweight consumed anthocyanin-rich elderberry juice twice daily for 1 week. After that week, gut microbiota composition had shifted, post-meal blood glucose was lower and fat oxidation was higher than after placebo.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Five ingredients, from each one's own page.
Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.
Blood zinc moves within days. The parts you would notice, skin behaviour and immune resilience, take four to twelve weeks of steady daily intake.
Gas and stool changes turn up in the first few days. The shift in the bacteria it feeds builds across two to four weeks of daily use.
It moves on a scale of days, not minutes. Studies that started daily use at the first sign of a sniffle followed the difference over the next two to four days.
Immune priming builds across one to two weeks of daily use. The change shows up in immune cell activity measures rather than in anything you feel.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.