35.1% of US adults
had at least one sunburn during the previous 12 months, in the 2024 National Health Interview Survey.
CDC National Center for Health Statistics, 2026Collagen peptides is the lead active here, studied most for skin health. 16 human studies on Collagen peptides back this formula, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 71 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
35.1% of US adults
had at least one sunburn during the previous 12 months, in the 2024 National Health Interview Survey.
CDC National Center for Health Statistics, 202650% of US adults
said they have a very or somewhat consistent skin care routine, in a YouGov survey fielded in April 2024.
YouGov, 202446% of US women
said they use moisturizer at least once a day, in a YouGov survey fielded in April 2024.
YouGov, 20249% of US women
said they would spend more than $60 on a single skin care product, in a YouGov survey fielded in April 2024.
YouGov, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics29.0% of US women
aged 18 and older said they always use sunscreen when outside for more than one hour on a sunny day, in the 2020 National Health Interview Survey.
CDC National Center for Health Statistics, 202259 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2023
Pooling 26 randomized trials in 1,721 people, hydrolyzed collagen improved skin hydration and elasticity compared with placebo.
NutrientsMeta-analysis, 2019
In adults with ongoing joint discomfort, pooled trials found collagen lowered self-reported discomfort by about 17 points on a 100-point scale and reduced stiffness more than placebo.
International OrthopaedicsRandomised trial, 2018
In postmenopausal women, 5 g of specific collagen peptides daily for 12 months increased bone mineral density at the spine and femoral neck compared with placebo.
NutrientsMeta-analysis, 2025
A pooled analysis of diet studies for aging skin linked oil supplements including evening primrose oil to better skin hydration and elasticity.
Journal of physiological anthropologyRandomised trial, 2026
Compared combined beta-alanine plus sodium bicarbonate against each alone on physical capacity measures in trained participants. The design is what makes the comparison informative for stacking decisions.
International Journal of Sports Physiology and PerformanceRandomised trial, 2026
Collagen type I content in skeletal muscle rose after 12 weeks of training with specific collagen peptides, which is a tissue composition marker rather than a strength or function outcome.
Frontiers in PhysiologyRandomised trial, 2015
In older men doing resistance training, 15 g of collagen peptides daily added about 1.3 kg more fat-free mass over 12 weeks than training with placebo, alongside larger gains in leg strength.
British Journal of NutritionRandomised trial, 2026
Microencapsulated sodium butyrate was tested against abdominal symptom scores and carbohydrate metabolism markers in adults with high blood sugar. Again a butyrate trial in which sodium is the carrier salt.
Scientific ReportsRandomised trial, 2020
In a controlled dietary intervention in adults, changing sodium and potassium intake shifted how the body handled calcium and phosphate, indicating that sodium intake affects normal mineral balance.
The Journal of Clinical Endocrinology and MetabolismSystematic review, 2026
A systematic review catalogued gastrointestinal symptoms reported across sodium bicarbonate dosing protocols and described how symptom burden varies with dose, timing and whether the dose is split or given with food.
European Journal of Sport ScienceRandomised trial, 2026
A randomised trial tested an algorithm-driven sodium supplementation protocol against usual care and measured growth in infants born preterm.
Pediatrics Open ScienceRandomised trial, 2025
In a trial of 104 very preterm infants, oral sodium supplementation raised daily weight gain by 3.6 grams per kilogram compared with placebo.
BMJ Paediatrics OpenPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In the excretion studies the EFSA reference opinion reviews, urinary output closely tracked dietary sodium once intake was held steady: 98% of dietary sodium appeared in 24-hour urine in a 3-day study, and 86% of sodium ingested over 4 weeks was recovered in 24-hour urine collected during the same period.
In the controlled metabolic study the EFSA reference opinion reviews, young men held at constant sodium intakes for 29 days per level showed rising average daily urinary aldosterone excretion as intake was stepped down from 4.9 g/day to 2.5 g/day.
In a randomised double blind placebo controlled trial, 77 healthy women took 5,000 mg a day of bioactive collagen peptides or placebo for 12 weeks with measurements at weeks 8, 12 and 16. Dermal density and hydration rose and transepidermal water loss fell against placebo at week 12, and those changes were still present after a 4 week washout rather than returning toward baseline. A second trial in 72 women separated from placebo at 8 weeks on hydration, elasticity and density, and retained the change 2 weeks after stopping. Both trials were run by or with the peptide manufacturers. A 2025 meta analysis of 23 randomised trials and 1,474 participants found these skin effects present in industry funded trials and absent in trials without industry funding, which is why the grade here is D.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
Fast. Sodium shifts fluid within an hour or two, which is why an electrolyte drink lands quickly when you have been sweating.
Give it eight to twelve weeks. Skin hydration and joint comfort measures shift across that stretch, and nails usually change sooner, around four to eight weeks.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.