Berberine is the lead active here, studied most for switching cleanly between fuels. 13 human studies on Berberine back this formula, each one cited. Each serving carries 1,000 mg of Berberine, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 2 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 274 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
49.1% of US adults
aged 20 and over tried to lose weight in the past 12 months, in the National Health and Nutrition Examination Survey fielded from 2013 to 2016.
CDC National Center for Health Statistics, 201815% of US adults
reported following a calorie-counting eating pattern in the past year, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202675% of US adults
said they were trying to limit or avoid sugar in their diet, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202657.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics47% of US adults
aged 20 and over kept added sugars under the Dietary Guidelines limit of 10 percent of daily calories, leaving more than half of US adults over that limit, in the What We Eat in America dietary recall component of NHANES 2015-2016.
USDA Agricultural Research Service, Food Surveys Research Group, 201995% of US adults
aged 20 and over ate one or more snacks on the day their diet was recorded, in the What We Eat in America dietary recall component of NHANES 2017 through March 2020.
USDA Agricultural Research Service, Food Surveys Research Group, 202459 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2020
Across 12 randomized trials, berberine reduced body weight by about 2 kg and body mass index by roughly 0.5 kg/m2.
Clinical Nutrition ESPENRandomised trial, 2025
In adults with elevated blood sugar, taking 1200 mg of berberine plus 600 mg of cinnamon daily for 12 weeks lowered fasting blood sugar, HbA1c, and LDL cholesterol.
European Journal of NutritionMeta-analysis, 2025
Across trials, berberine lowered LDL cholesterol by about 0.5 mmol/L and triglycerides by about 0.37 mmol/L.
Frontiers in PharmacologyMeta-analysis, 2023
Pooling 20 trials in about 1,761 adults, berberine lowered fasting blood sugar by roughly 0.5 mmol/L.
The Journal of NutritionRandomised trial, 2026
In eight adults, 1.5 g of berberine for 7 days before an hour's exercise in heat lowered heart rate to 163 beats per minute, versus 166 with placebo.
Physiological ReportsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a placebo-compared trial, 8 healthy young adults took 1.5 g of berberine daily for 7 days before running an hour in 35 degree heat. Mean body temperature, heart rate, respiratory rate, thermal sensation and general discomfort during the run were all modestly lower with berberine than placebo. One small trial of 8 people.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Two ingredients, from each one's own page.
Before a fasting glucose or lipid panel shifts. It's a change you read on paper, not one you sense.
Digestive changes tend to show up within a week or two. Anything to do with skin is slower, usually four to eight weeks of daily use before it's visible.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
