Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. 1,3-DMAA has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
DMAA is an indirect sympathomimetic and caffeine is an adenosine antagonist that raises catecholamine tone. The two were studied together in healthy men and the pairing is the one most often seen in pre-workout formulas. Their cardiovascular effects add rather than offset, and blood pressure is the measure that moves. This is a reason for caution, not a reason to combine.
Yohimbine blocks alpha-2 autoreceptors, which removes the brake on noradrenaline release. DMAA pushes the same transmitter out from the other direction. Stacking a releaser with an autoreceptor blocker is a recognised way to amplify pressor effects well beyond either alone. Count this as an anti-synergy.
Nitrate-derived nitric oxide relaxes vessels while an adrenergic amine constricts them. Putting both in one pre-workout gives a blood pressure response that cannot be predicted from either ingredient's data. The interaction is real but its direction is not fixed.
Theanine is added beside stimulants to soften the subjective edge of arousal. It does not reduce the pressor load of a sympathomimetic amine and should not be read as protective. The change is in perceived jitter only.
Nothing specific on file for 1,3-DMAA. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 2 we read for 1,3-DMAA. The full linked list is below.
1 source behind our 1,3-DMAA verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.