Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Ceanothus integerrimus has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
The saponin and tannin content that makes Ceanothus bark lather in water is the same content that complexes minerals in the gut. Anyone taking iron to build iron status should separate the doses by a couple of hours. The interaction is on iron in the same meal, not on stored iron.
Tannins bind proteins non-specifically, and supplemental digestive enzymes are proteins. Taking a tannin-bearing bark preparation alongside an enzyme blend can reduce the enzyme activity that survives to act. Spacing the two avoids the issue. The inhibition is characterised in vitro and has not been quantified for this species.
Zinc shares iron's vulnerability to polyphenol and saponin binding, though it is less studied. Separating a zinc dose from a saponin-bearing bark preparation is a sensible timing precaution. This is a mechanistic expectation rather than a measured result for this species.
Astringent tannin preparations tighten and dry tissue on contact, and demulcent mucilage herbs are the traditional counterweight. This is a preparation convention drawn from herbal practice, not a tested combination. Nothing has compared the pair against either herb alone.
Nothing specific on file for Ceanothus integerrimus. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.Read this carefully. These are 29 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Ceanothus integerrimus is, not how risky it is. A report is not proof Ceanothus integerrimus caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.