Flavones (various).
A family of plant compounds from parsley, celery, chamomile and citrus peel, apigenin and luteolin among them. They're used for calm, evening wind-down and antioxidant support.
- Category
- Compound
What Flavones (various) is, and what it does.
- Does it work
- Suits people who want a plant-based calm ingredient in the evening, and formulators after an antioxidant that isn't quercetin. The class is broad, so the named flavone matters.
- How much to take
- No daily amount is on record for flavones as a class. Go by the named flavone and its extract's standardised milligram figure rather than by the class label.
- Time to feel it
- Chamomile and apigenin work is usually read over weeks of evening use. Any same-evening settling is mild, and nobody has pinned a reliable onset time to it.
- The first dose
- The first evening is quiet, at most a mild settling before bed. Nothing dramatic lands on day one, which is ordinary for a polyphenol.
- With regular use
- Weeks of evening use is where the calm and sleep-quality signals in this class sit. The antioxidant side runs in the background rather than as something you track.
- How well tolerated
- Generally well tolerated. Several flavones bind the same receptor site as sedatives, so take care combining them with anything sedating and check with your doctor.
- How it feels
- Most people describe a mild settling in the evening rather than drowsiness. Past that there isn't much to notice, which is typical for this class of compound.
- The overlooked benefit
- Flavones grab iron and copper through their keto and hydroxyl groups. That's the antioxidant mechanism, and also why a flavone-rich drink cuts iron uptake from a plant meal.
The proof, claim by claim.
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
- Calm and evening wind-downRandomised trial
- Sleep qualityRandomised trial
- Binding at the benzodiazepine site of the GABA-A receptorIn vitro study
- Antioxidant and metal-chelating activityIn vitro study
- A healthy inflammatory responseAnimal study
Why these belong in the same formula. Each row says what the basis is, from settled biochemistry through to a trial that measured the pair.
When a flavone donates a hydrogen atom to a radical it becomes a phenoxyl radical itself, and ascorbate can reduce that species back to the parent phenol. The chemistry is well described in solution and in model membranes. Whether the same recycling loop changes any measured outcome in a person is a separate question that this mechanism does not answer.
Both classes are handled by intestinal and hepatic UGT and SULT enzymes, which have finite capacity. Taken together at high intake they compete for the same conjugation route, which can raise circulating unconjugated levels of one or both. That is a pharmacokinetic point, not a claim of added benefit.
Phospholipid complexes and lecithin dispersions raise the fraction of a poorly soluble flavone that stays in solution through the small intestine. This is a formulation answer to a dissolution problem. It changes exposure, not the intrinsic activity of the molecule.
Poplar-type propolis carries chrysin and related flavones as part of its native profile, so combining the two raises total flavone intake from a source that already contains them. The pairing is compositional overlap. Propolis content varies sharply with the botanical origin of the resin.
Flavones form coordination complexes with iron and copper through the 4-keto and adjacent hydroxyl positions. In the gut lumen that lowers the fraction of a non-heme iron dose available for uptake. Spacing the two apart is the usual handling.
The same keto-hydroxyl chelation site that binds iron also binds zinc and copper, so a high polyphenol load in the same serving reduces free divalent mineral in the lumen. The size of the effect depends on the flavone concentration and on what else is in the meal.
A large share of ingested flavones reaches the colon unabsorbed, where bacterial enzymes cleave the C ring into phenylacetic and phenylpropionic acid fragments that are then absorbed. Which fragments appear depends on which organisms are present. This is why two people given the same dose show different metabolite profiles.
Nothing specific on file for Flavones (various). Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.What Flavones (various) actually does.
Flavones share a core chemical structure that's missing one specific hydroxyl group, and that single difference is what separates them from flavonols like quercetin and kaempferol.
The flavones you'll most often see named on labels are apigenin, luteolin, chrysin, baicalein and diosmetin, found naturally in foods and plants like parsley, celery, chamomile, Scutellaria root and citrus peel.
When you swallow flavones, your gut and liver quickly modify most of them before they even reach circulation, so the free form stays low in your blood and what's actually circulating is mostly a modified version.
Part of the flavone structure lets it grab onto metals like iron and copper, and that same feature is what lets it act as an antioxidant that interrupts chain reactions in fats, at least in lab lipid systems.
Where Flavones (various) comes from.
These come out of ordinary plants like parsley, celery, chamomile and citrus peel, pulled out with solvent and then cleaned up into a powder.
The same molecule is reached more than one way. Which route a given product used is a manufacturing choice, and the finished compound is the same either way.
Parsley and celery for apigenin, Scutellaria baicalensis root for baicalin, chamomile flower for apigenin glycosides, citrus peel for diosmetin, or a chalcone precursor for synthetic routes
Ethanol, methanol or acetone with water pulls the glycosides from milled plant material
Acid or enzymatic hydrolysis cleaves the sugar to give the free flavone where the aglycone is what the label states
Macroporous resin cleanup followed by crystallisation raises assay purity, commonly to 95 percent or higher for single compounds
Sold as a crystalline aglycone, a phospholipid complex, or a standardised plant extract
Getting Flavones (various) from food.
The whole-food sources on file. A supplement closes the gap, it does not replace dinner.
A gram-for-gram figure (how much of each you would eat to match a dose) will appear here once it is sourced and reviewed. This page will not print a number it cannot cite.
The forms it comes in.
The essence, in one line each.
- A systematic review of animal work reported that several dietary supplement classes, flavonoids among them, showed anti-inflammatory signals in rodent models of gut inflammation.Systematic review. Mulinari Turin de Oliveira N et al., 2025 (Nutrition reviews). PMID 39992299 ↗
- A narrative review describing flavonoids as modulators of neuroinflammatory signalling, with the mechanistic case ahead of the clinical case.Narrative review. Rosas-Sanchez GU et al., 2026 (International Journal of Molecular Sciences). PMID 42196538 ↗
These are the studies our verdict leans on, chosen from the 2 we read for Flavones (various). The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.