Humanin.
Mitochondrial peptide for cellular protection and longevity A 24 amino acid peptide your own mitochondria make and release into the blood as a signal. What is known comes from cells, animals and blood measurements rather than from oral use.
Reviewed March 2026
- Category
- Peptide
- Also filed under
- NeuroprotectionLongevityCellular Protection
What Humanin is, and what it does.
- Does it work
- Suits people who follow mitochondrial and ageing research closely and want the compound itself. Anyone looking for a measured oral timeline in people will find that work has not been done.
- How much to take
- The band on record is 1mg to 5mg a day. Research administration was by injection rather than by mouth, so no oral daily amount has been established in people.
- Time to feel it
- No timeline has been measured for people taking it by mouth. Research administration was by injection, and the readouts were laboratory measures taken over weeks.
- The first dose
- There's no acute effect to clock on day one. A peptide this size is broken down by digestive enzymes as protein is, and research readouts were lab measures taken later.
- With regular use
- Long-term human supplement studies have not been run. Cell and animal work points to stress signalling in mitochondria, and that has not been carried into weeks of oral use.
- How well tolerated
- Human data for oral use is absent, so nobody can say how it behaves over weeks. Check with a clinician before starting any peptide product.
- How it feels
- There is no reported sensation. Any effect described in the literature sits at the level of cell signalling read by lab measures, not something you would register during a day.
- The overlooked benefit
- The widely cited HNG analogue swaps serine for glycine at position 14. It is a different molecule from native humanin, so results for one are not results for the other.
1 to 5mg a day is where Humanin works.
Source: Hashimoto et al. Proc Natl Acad Sci 2001; Yen et al. Aging Cell 2013
The proof, claim by claim.
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
Humanin has emerging evidence. Based on 1851+ studies.
- Cell survival signalling under stressIn vitro study
- Metabolic signalling in animal modelsAnimal study
- Circulating levels as an age related markerCohort study
Questions people ask about Humanin.
- When should I take it?
- Timing matters less than consistency. Pick a time that works for you and take it daily.
- Can I take it with other supplements?
- Usually fine. The main thing to watch is not doubling up on the same ingredient from different products. If you're on prescription meds, check with your pharmacist first.
- Any side effects to watch for?
- Most people tolerate it well at recommended doses. GI upset is the most common complaint with any supplement. Start with a lower dose and work up. If something feels off, stop and reassess.
- Who benefits most from this?
- Honestly, most people would benefit more from the basics. But if you've got a specific reason to try it, the risk is generally low.
No pairing data for Humanin yet.
Nothing on file for Humanin, either from a combination trial or from settled biochemistry. When either lands, it appears here with its source.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
21 pairings are live across the library today. Checked 9 August 2026.
Nothing specific on file for Humanin. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.Getting Humanin from food.
The whole-food sources on file. A supplement closes the gap, it does not replace dinner.
A gram-for-gram figure (how much of each you would eat to match a dose) will appear here once it is sourced and reviewed. This page will not print a number it cannot cite.
The studies, linked.
3 sources behind our Humanin verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
- Clinical trialProspective Clinical Observational Study of Humanin Isoforms in Cardiac Muscle and Blood Plasma and Their Association to Major Complications After Cardiac OperationClinicalTrials.gov ↗106 participants · Completed
- Clinical trialComparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation: A Prospective Controlled StudyClinicalTrials.gov ↗NA · 68 participants · Recruiting
- ClinicalTrials.gov ↗
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.