Chromium is the lead active here, studied most for healthy insulin response. 13 human studies on Chromium back this formula, each one cited. Who it fits: skews toward women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 6 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 277 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
49.1% of US adults
aged 20 and over tried to lose weight in the past 12 months, in the National Health and Nutrition Examination Survey fielded from 2013 to 2016.
CDC National Center for Health Statistics, 201815% of US adults
reported following a calorie-counting eating pattern in the past year, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202675% of US adults
said they were trying to limit or avoid sugar in their diet, in the International Food Information Council's 2025 Food and Health Survey.
International Food Information Council, 202657.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics47% of US adults
aged 20 and over kept added sugars under the Dietary Guidelines limit of 10 percent of daily calories, leaving more than half of US adults over that limit, in the What We Eat in America dietary recall component of NHANES 2015-2016.
USDA Agricultural Research Service, Food Surveys Research Group, 201995% of US adults
aged 20 and over ate one or more snacks on the day their diet was recorded, in the What We Eat in America dietary recall component of NHANES 2017 through March 2020.
USDA Agricultural Research Service, Food Surveys Research Group, 202459 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015USDA advises fortified foods or supplements after 50
In its national intake tables USDA notes that "it is advised that individuals over 50 meet their B12 requirement with fortified foods or supplements".
NHANESMeta-analysis, 2025
Pooled trials in women undergoing assisted reproduction found myo-inositol was linked to modest improvements in egg and embryo quality measures.
Frontiers in endocrinologyMeta-analysis, 2019
Pooling 1,316 participants with excess body weight, chromium supplementation was associated with about 0.75 kg more weight loss and about 0.68 percentage points lower body fat than placebo, a small effect the authors call of uncertain clinical relevance.
The paperMeta-analysis, 2013
Pooling six trials in 392 adults carrying excess body weight, chromium picolinate at 200 to 1000 micrograms lowered body weight by 1.1 kg over 12 to 16 weeks (95% CI -1.7 to -0.4) on low-quality evidence, with no dose gradient established.
Cochrane Database of Systematic ReviewsMeta-analysis, 2026
An umbrella review of meta-analyses found inositol improved insulin sensitivity and lowered circulating androgen levels in women with irregular ovulation.
Frontiers in endocrinologyMeta-analysis, 2014
In a meta-analysis of 25 randomized trials in adults managing blood sugar, chromium supplementation lowered HbA1c by about 0.55 percentage points and fasting glucose by about 1.15 mmol/L, with the glucose effect most evident for chromium picolinate.
Journal of Clinical Pharmacy and TherapeuticsRandomised trial, 2026
In 40 adults with clustered metabolic risk factors, 400 micrograms of chromium picolinate daily for 12 weeks lowered the blood marker HbA1c by 0.68%, raised HDL cholesterol by 4.8 mg/dL and lowered systolic blood pressure by 4.8 mmHg, with no change in DNA-damage or inflammatory gene markers.
Biological Trace Element ResearchRandomised trial, 2023
Diindolylmethane supplementation shifted measured estrogen metabolism toward the 2-hydroxyestrone route, raising the urinary 2-hydroxyestrone to 16-alpha-hydroxyestrone ratio. This ratio is a marker, not an outcome.
The paperSystematic review, 2024
An extensive review of chromium supplementation found the human literature mixed, with heterogeneity in dose, form and baseline status.
Environmental Geochemistry and HealthRandomised trial, 2023
Dietary supplementation with DIM or Brussels sprouts altered the measured handling of an ingested polycyclic aromatic hydrocarbon in humans, consistent with induction of the enzymes that process it.
Toxicology and Applied PharmacologySystematic review, 2025
Across 16 studies in 6,098 people, vitamin B12 raised blood B12 levels by about 403 pg/mL, with oral or under-the-tongue doses working about as well as injections.
Frontiers in pharmacologyRandomised trial, 2024
Adults taking methylfolate, pyridoxal-5'-phosphate and methylcobalamin together lowered circulating homocysteine compared with placebo.
NutrientsSystematic review, 2023
Human studies show glucosinolate breakdown products, including diindolylmethane, appear in blood and urine after cruciferous vegetable intake, with wide person to person variation driven by gut bacteria and food processing.
NutrientsSystematic review, 2026
A Cochrane review found vitamin B12 supplementation improves vitamin B12 status, while effects on blood counts were less certain.
The Cochrane database of systematic reviewsRandomised trial, 2020
A placebo-controlled trial measured breast tissue density on imaging, an imaging marker, in healthy women carrying a BRCA gene variant after taking DIM.
CarcinogenesisOpen-label trial, 2026
Investigators report that L-methylfolate with methylcobalamin lowered serum homocysteine and blood pressure readings in adults with hard to control elevated blood pressure and raised homocysteine. Homocysteine is a marker.
BMC nephrologyRandomised trial, 2026
In a crossover trial of 30 healthy adults aged 18 to 80, four weeks of an astragalus and panax saponin extract taken with whey protein raised valine absorption by about 14% and leucine by about 8%, with grip strength up 5.2% versus 2.4% on placebo and blood zonulin down 13.0% versus 0.9%.
NutrientsRandomised trial, 2025
In 22 trained adults, a single dose of a multi-ingredient pre-workout drink containing AstraGin raised total volume load by about 4.4% and repetition rate by about 2.2% across 5 and 15 minute high-intensity sessions, with no change in total repetitions completed. The design cannot attribute the effect to any one ingredient.
Journal of the International Society of Sports NutritionRandomised trial, 2026
Two oral B12 doses were compared for nerve-related outcomes, but the report only describes the difference between them, not which dose is better.
The Journal of nutritionSystematic review, 2025
A review summarizes reported immune-related changes when B12 levels are restored in adults with impaired absorption, noting the evidence base is small and doesn't test this specific form on its own.
Oxidative medicine and cellular longevitySystematic review, 2024
Across the human studies reviewed, usual intake of brassica vegetables and their breakdown products did not show a consistent effect on thyroid hormone levels in people with adequate iodine, which is a failure to detect an effect rather than proof of none.
International journal of molecular sciencesMeta-analysis, 2024
Across 14 randomised trials in adults with elevated blood sugar, chromium supplementation did not measurably change body weight (-0.26 kg), BMI, waist circumference or fat mass, with a fat-mass reduction seen only in subgroups aged 55 and over and on the picolinate form.
Journal of Trace Elements in Medicine and BiologyMeta-analysis, 2026
Pooled trials found that myo-inositol taken during pregnancy was followed by a lower rate of elevated blood sugar, though most trials came from a small number of centers.
American Journal of Obstetrics and GynecologyMeta-analysis, 2026
This meta-analysis of inositol supplementation during pregnancy reports reduced incidence of elevated blood sugar in the supplemented arms, with the authors calling for larger multi-centre confirmation.
International Journal of Gynaecology and ObstetricsMeta-analysis, 2022
Across the pooled randomised controlled trials, antenatal myo-inositol was associated with a lower rate of raised blood sugar in pregnancy compared with control, with heterogeneity between trials noted.
European Journal of Obstetrics, Gynecology, and Reproductive BiologyMeta-analysis, 2022
The pooled analysis reports a reduction in the incidence of raised blood sugar during pregnancy with myo-inositol supplementation, with the authors flagging small individual trial sizes.
Gynecological EndocrinologyPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.
A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Six ingredients, from each one's own page.
The urinary oestrogen metabolite ratio moves within two to four weeks of daily use. Changes you would notice yourself, in skin or cycle patterns, sit nearer four to eight weeks.
Red cell folate climbs over roughly four to eight weeks. It's a blood panel change rather than a sensation.
Serum B12 rises within days of daily use. Methylmalonic acid, the marker of supply inside cells, settles across four to twelve weeks, and anything noticeable follows that.
It works through insulin signalling, so the earliest read on it is a fasting glucose or insulin number rather than a sensation.
There is no timeline of its own to give. It acts on the absorption of whatever it sits beside, so any change follows that other ingredient's own timeline.
Calm and sleep effects, where they show, tend to land inside one to two weeks. Cycle and insulin measures move slower, usually across two to three months.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
Cobalamin carrying a methyl group on the cobalt centre, the same species used directly by methionine synthase.
Tris(picolinato)chromium(III), a neutral coordination complex of one chromium(III) ion and three picolinic acid ligands
Fine off-white to tan powder, water dispersible, carrying triterpene saponins from both roots. The manufacturer standardises to its own internal marker profile rather than a publicly named compound.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a capsule, so the amount per serving is fixed and travels without measuring.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.
