About 10% of US women of reproductive age
are iron deficient.
Peer-reviewed analysisIodine is the lead active here, studied most for iodine status. 13 human studies on Iodine back this formula, each one cited. Each serving carries 200 mg of DHA, inside the range the published research used. Who it fits: made for women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 6 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Stronger in a pair".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 1,784 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 10% of US women of reproductive age
are iron deficient.
Peer-reviewed analysisUnder 250 mg a day
US adults average well under the 250 mg a day of EPA and DHA that health authorities suggest for heart health.
Peer-reviewed analysisAbout 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisAbout 42% of Americans
take in less calcium than the estimated average requirement.
NHANESAbout 18% of US women aged 19 to 50
take in less folate from food and drink than the estimated average requirement.
NHANESAbout 20% of US women aged 19 to 30
take in less iron from food and drink than the estimated average requirement.
NHANESMore than 97% of US women aged 19 and over
take in less vitamin D from food and drink than the estimated average requirement.
NHANESAbout 75% of US women aged 51 to 70
take in less calcium from food and drink than the estimated average requirement.
NHANESAbout 19% of US women aged 31 to 50
take in less iron from food and drink than the estimated average requirement.
NHANESMore than 97% of US women aged 51 to 70
take in less vitamin D from food and drink than the estimated average requirement.
NHANESAbout 59% of US women aged 19 and over
take in less calcium from food and drink than the estimated average requirement.
NHANES74% of US adults
take dietary supplements, and 55% are regular users, in the Council for Responsible Nutrition's 2023 consumer survey of 3,192 adults.
Council for Responsible Nutrition and Ipsos, 202392% of US supplement users
agree that dietary supplements are essential to maintaining their health, in the Council for Responsible Nutrition's 2023 consumer survey.
Council for Responsible Nutrition and Ipsos, 202312.3% of US adults
met the fruit intake recommendation and 10.0% the vegetable recommendation in 2019, in the Behavioral Risk Factor Surveillance System across 49 states.
CDC, MMWR, 202215% of US adults
aged 20 and over ate no breakfast on the day of their dietary recall, in the 2017 to March 2020 What We Eat in America survey.
USDA Agricultural Research Service, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health StatisticsUS pregnant women, median 129 micrograms per litre
Between 2005 and 2010, US pregnant women had a median urine iodine level of 129 micrograms per liter, below the range considered adequate in pregnancy.
Peer-reviewed analysis60.2% of US adults aged 20 and over
took a dietary supplement in the past 30 days, and 38.7% took two or more, in the 2021 to 2023 National Health and Nutrition Examination Survey.
CDC National Center for Health Statistics, 202659 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2011
In trials giving DHA by itself, DHA lowered triglycerides and raised HDL cholesterol by about 4.5 mg/dL compared with placebo.
The paperMeta-analysis, 2025
Across 20 trials in pregnant women, iron-folic acid formulations varied in hemoglobin response and reported tolerance, with dose and frequency mattering more than the specific iron salt.
BMC pregnancy and childbirthRandomised trial, 1997
In iodine-deficient adults, 0.2 mg of iodide daily reduced thyroid gland volume by about 38% over 12 months compared with placebo.
Journal of Clinical Endocrinology and MetabolismMeta-analysis, 2024
Across 10 trials in 318 athletes, vitamin D3 raised blood vitamin D by about 14.8 nmol/L and hinted at better muscle strength, though few trials leave that uncertain.
Frontiers in NutritionMeta-analysis, 2014
Pooling 30 trials of 5,615 adults, vitamin D gave a small rise in overall muscle strength, with no measurable effect on muscle mass or power.
Journal of Clinical Endocrinology and MetabolismRandomised trial, 2025
Vitamin D3 supplementation changed the inflammatory protein CHI3L1 and oxidative stress markers in adults with a chronic demyelinating condition. These are markers, not clinical outcomes.
Neuropsychopharmacology ReportsSystematic review and meta-analysis, 2020
In pregnant women with mild to moderate iodine deficiency, iodine lowered a thyroid marker and curbed the usual pregnancy rise in thyroid size. Infant cognitive, language and motor scores showed no change across trials.
American Journal of Clinical NutritionSystematic review, 2025
The review reports inconsistent associations between folic acid supplementation in pregnancy and later blood sugar handling, and calls for dose-resolved data. Association, not cause.
International journal of molecular sciencesMeta-analysis, 2023
200 micrograms of iodine a day raised iodine levels and shifted thyroid hormones in pregnancy across 11 studies.
Journal of Trace Elements in Medicine and BiologyMeta-analysis, 2026
Pooled data found that women who had been pregnant before were more likely to take folic acid, an association about behavior, not an effect of the vitamin itself.
BMJ openMeta-analysis, 2026
In pregnant women with low iodine status, iodine was linked to lower TSH and thyroglobulin in the blood, both markers rather than health outcomes.
Frontiers in Public HealthRandomised trial, 2022
In 120 pregnant women, 24 mg iron as ferrous bisglycinate absorbed better within two hours than 66 mg ferrous fumarate, both raising iron levels over six months, with fewer gut side effects for bisglycinate.
NutrientsSystematic review, 2021
Across pooled studies, iodine supplementation in pregnancy shifted maternal iodine status and thyroid function measures, while effects on offspring endpoints were inconsistent between studies.
European Journal of EndocrinologyMeta-analysis, 2005
Across 25 trials in 2,596 people, 0.8 milligrams or more of folic acid a day lowered blood homocysteine by about 23 to 25 percent, and 0.4 milligrams by about 20 percent.
Am J Clin NutrMeta-analysis, 2024
Across 20 studies, daily vitamin D3 raised blood vitamin D levels by about 10.4 nmol/L more than the same dose of vitamin D2, roughly 40 percent more.
Advances in NutritionMeta-analysis, 2012
In trials directly comparing the two forms, vitamin D3 raised blood 25-hydroxyvitamin D more than vitamin D2 did (P = 0.001).
American Journal of Clinical NutritionMeta-analysis, 2025
Across pooled trials, folic acid consistently lowered a blood marker called homocysteine, with less consistent change in more meaningful health outcomes.
BMC nutritionMeta-analysis, 2024
Pooling randomised comparisons, no clear difference was detected between heme and non-heme iron preparations in haemoglobin and ferritin response, with tolerance differing between forms.
European journal of nutritionMeta-analysis, 2025
In children and adolescents with low iron stores, longer supplementation courses raised haemoglobin more than short courses, while higher doses added little beyond moderate doses.
PloS oneMeta-analysis, 2026
Across 9 placebo-controlled eccentric exercise trials in healthy adults, supplements combining DHA with EPA reduced delayed onset muscle soreness (Hedges g -0.75, 95% CI -1.14 to -0.36). The wider body of 43 studies was mixed, and the trials tested the two fats together rather than DHA alone.
NutrientsMeta-analysis, 2025
Comparing dosing schedules, alternate-day oral iron produced haemoglobin gains that were not clearly different from daily dosing, while fewer gastrointestinal complaints were reported.
BMC pharmacology & toxicologySystematic review, 2021
In areas with low population iodine intake, supplementation during pregnancy was associated with better neurocognitive development scores in offspring in some but not all included studies.
Archives of Endocrinology and MetabolismRandomised trial, 2025
In a double-blind noninferiority crossover, the authors did not detect a difference in the primary blood marker between folic acid and placebo. A failure to detect a difference is not evidence that none exists.
The American journal of clinical nutritionMeta-analysis, 2014
Across 23 trials of 4,082 adults, vitamin D raised bone mineral density at the femoral neck by about 0.8%, with no measurable change at the spine, hip, or other sites.
LancetSystematic review, 2013
Across 111 studies covering 10,695 people, ferrous fumarate carried the highest reported side-effect rate among the oral iron supplements compared, at 47.0 percent overall and 43.4 percent gut-related.
Current Medical Research and OpinionRandomised trial, 2010
Formula-fed infants given DHA-enriched formula from 0.32% of fatty acids developed better visual acuity by 12 months than infants on DHA-free formula.
American Journal of Clinical NutritionMeta-analysis, 2024
Pooling 9 randomised trials of DHA given before or after birth, infants in the DHA groups scored 1.47 points higher on the Psychomotor Development Index (95% CI 0.23 to 2.72), with no difference detected on the Mental Development Index.
Frontiers in NeurologyMeta-analysis, 2022
Across 71 trials, omega-3 (DHA and EPA together) at 2 to 3 grams a day lowered the top blood pressure number by about 2.6 points.
Journal of the American Heart AssociationRandomised trial, 2026
In 26 amateur runners, 12 weeks of DHA and EPA raised red blood cell omega-3 levels while placebo stayed the same, blood markers not performance outcomes.
Prostaglandins, Leukotrienes and Essential Fatty AcidsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.
A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.
A randomised crossover study in 54 nonanemic young women with plasma ferritin at or below 20 ug/L gave labelled iron sulfate as single fasting morning doses of 40, 60, 80, 160 and 240 mg. Twenty four hours after doses of 60 mg or more, serum hepcidin was raised and fractional iron absorption from the following dose was 35% to 45% lower. Across the dose range a sixfold rise in dose, 40 to 240 mg, produced a threefold rise in iron absorbed, 6.7 to 18.1 mg. Total iron absorbed from three doses inside 24 hours was not significantly greater than from two morning doses. The measure was iron absorption and serum hepcidin, not a symptom.
In a randomised single-blind trial, 20 participants took either fish oil supplying 1,296 mg EPA and 864 mg DHA daily or flaxseed oil for eight weeks, with erythrocyte membrane and plasma samples drawn at weeks 0, 4, 8, 10, 12, 14, 16 and 24. On fish oil, erythrocyte membrane EPA rose 300 percent and DHA rose 42 percent by week eight. Levels held until about week 12 and then declined across the post-supplementation sampling, faster in plasma phospholipids than in erythrocyte membranes. Membrane fatty acid content was measured, not a symptom, and this is one trial of 20 people.
In a randomised double-blind crossover trial, healthy men and women aged 19 to 34 took capsules supplying about 4 g DHA per day, with plasma sampled at days 0, 1, 3, 7, 14 and 28. DHA concentrations tripled and so did DHA-derived oxylipins. Increases were detectable as early as day 1, and 11 of 12 individual DHA oxylipins plus total DHA oxylipins reached a plateau by days 5 to 7. The plateau came earlier and was reached by more oxylipins in females than in males. Plasma marker chemistry was measured, not a feeling.
In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.
A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.
In a 24 week randomised double-blind placebo-controlled trial in 112 mildly iodine-deficient New Zealand adults aged 18 to 40, 150 micrograms of iodine a day as potassium iodate lowered thyroglobulin, a blood marker of iodine status, by 12 percent at 8 weeks, 20 percent at 16 weeks and 27 percent at 24 weeks compared with placebo. Median urinary iodine reached 168 micrograms per litre against 79 on placebo. TSH and free T4 stayed within normal range and did not change significantly.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Six ingredients, from each one's own page.
Serum folate climbs within a few hours of a dose and red cell folate takes about eight to twelve weeks to plateau. The change lands on a blood panel, not in how you feel.
Iron stores rebuild slowly. Haemoglobin readings usually move across three to four weeks and ferritin over two to three months, which is why this one is tracked with blood work.
Membranes fill slowly. The omega 3 index moves over eight to twelve weeks, and the trials reporting cognitive or eye comfort changes run three to six months.
25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.
No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.
Thyroid hormone turns over slowly, so the change lands on a urinary iodine measure and a thyroid panel before it lands anywhere in your day.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
Ferrous salt of fumaric acid, about 33 percent elemental iron, moderately water-soluble
The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.
In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.