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Super Omega-3
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Verified by IngredientMD/Life Extension/Super Omega-3
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Super Omega-3.

Backed by human trialsLife Extension, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Life Extension.

Wild Fish Oil Concentrate is the lead active here, studied most for blood flow. 15 human studies on Wild Fish Oil Concentrate back this formula, each one cited. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
8Active ingredients74Human studies2000 mgWild Fish Oil Concentrate
Super Omega-3Verified by IngredientMD
Life ExtensionIngredientMD
The verdict
Backed by human trials
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Wild Fish Oil Concentrate: Blood flowKey driver
EPA (eicosapentaenoic acid): Triglycerides already in the normal rangeExtensively studied
DHA (docosahexaenoic acid): Triglycerides already in the normal rangeExtensively studied
Olive extract (fruit and leaf): Cholesterol already in the normal rangeSupporting role
Polyphenols: Heart and circulationWell studied
Hydroxytyrosol/Tyrosol: Cholesterol already in the normal rangeWell studied
Verbascoside/Oleuropein: Cholesterol already in the normal rangeWell studied
Sesame seed lignan extract: Cholesterol already in the normal rangeSupporting role

How we read this product

Source: Supplement facts
Supplement Facts panel for Super Omega-3
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 8 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

74
Human studies
2000 mg
Wild Fish Oil Concentrate
700 mg
EPA (eicosapentaenoic acid)
500 mg
DHA (docosahexaenoic acid)
2 g per serving sits inside the studied 500 mg-2 g range
Wild Fish Oil Concentrate, GISSI-HF 2008 + AHA 2019 Guidelines

Cross-checked against 631 documented interactions for these actives.

Read the evidenceWild Fish Oil Concentrate, the evidence →EPA (eicosapentaenoic acid), the evidence →DHA (docosahexaenoic acid), the evidence →Olive extract (fruit and leaf), the evidence →Polyphenols, the evidence →Hydroxytyrosol/Tyrosol, the evidence →

Inside the formula

Wild Fish Oil Concentrate
15 studies
Blood flow
Key driver
EPA (eicosapentaenoic acid)
15 studies
Triglycerides already in the normal range
Extensively studied
DHA (docosahexaenoic acid)
14 studies
Triglycerides already in the normal range
Extensively studied
Olive extract (fruit and leaf)
Cholesterol already in the normal range
Supporting role
Polyphenols
12 studies
Heart and circulation
Well studied
Hydroxytyrosol/Tyrosol
Cholesterol already in the normal range
Well studied
Verbascoside/Oleuropein
Cholesterol already in the normal range
Well studied
Sesame seed lignan extract
Cholesterol already in the normal range
Supporting role
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
The people it speaks toFieldwork December 15 to 17, 2023

Fewer than 1 in 5 US adults

know their cholesterol or blood sugar numbers, according to a national survey fielded for The Ohio State University Wexner Medical Center in December 2023.

SSRS Opinion Panel Omnibus for The Ohio State University Wexner Medical Center, 2023
41 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Wild Fish Oil Concentrate

Meta-analysis, 2017

Across 51 trials in about 3,000 people, marine omega-3s lowered resting heart rate by about 2.2 beats per minute, an effect linked to DHA rather than EPA.

European Journal of Clinical Nutrition
Wild Fish Oil Concentrate

Meta-analysis, 2023

Across 90 trials in 72,598 people, higher daily DHA and EPA intake lowered blood triglycerides and non-HDL cholesterol in a near-linear way, most clear above about 2 g a day.

Journal of the American Heart Association
Olive extract (fruit and leaf)

Systematic review, 2025

Reviewing human studies, regular extra virgin olive oil intake was associated with better blood vessel function and improved blood lipid measures.

Nutrients
Polyphenols

Meta-analysis, 2026

A pooled analysis of trials of polyphenol intake reported neurological and cognitive measures, with certainty ratings given for each estimate.

Food and Function
Verbascoside/Oleuropein

Randomised trial, 2026

In adults with mildly to moderately raised blood pressure, olive leaf extract given together with potassium lowered blood pressure relative to control, so the effect belongs to the combination.

Phytomedicine
Hydroxytyrosol/Tyrosol

Randomised trial, 2025

In adults with higher liver fat, hydroxytyrosol improved liver fat and metabolic readings, and the change tracked alongside shifts in the gut microbiota.

Journal of Agricultural and Food Chemistry
Polyphenols

Meta-analysis, 2026

A certainty-rated pooling of curcumin trials reports pooled results alongside how confident the authors are in each one.

Phytotherapy Research
Wild Fish Oil Concentrate

Meta-analysis, 2026

Pooling nine placebo-controlled eccentric-exercise trials in healthy adults, long-chain omega-3 fats reduced delayed onset muscle soreness (Hedges g -0.75) and the muscle-damage marker creatine kinase (-0.40) and improved muscle strength (0.45) and range of motion (0.93) at the point of worst impairment.

Nutrients
EPA (eicosapentaenoic acid)

Meta-analysis, 2021

Across 33 trials, DHA lowered blood triglycerides and raised HDL cholesterol by about 0.07 mmol/L, but also raised LDL cholesterol by about 0.26 mmol/L.

Clinical Nutrition
DHA (docosahexaenoic acid)

Meta-analysis, 2020

Across trials in older adults with mild memory complaints, DHA was linked to better memory test scores, though no difference was detected in those without complaints, which does not mean none exists.

European journal of clinical pharmacology
EPA (eicosapentaenoic acid)

Meta-analysis, 2026

Pooled trials looked at omega-3s against inflammation markers and recovery measures in sport, with omega-6 relevance only indirect through shared pathways.

FASEB journal
Sesame seed lignan extract

Cohort study, 2024

Reported that the association between dietary vegetable oil intake and cardiometabolic risk factors differed by FADS1 rs174556 genotype.

Scientific Reports
Polyphenols

Randomised trial, 2026

In postmenopausal women, a polyphenol supplement raised some blood fat levels while improving LDL particle quality and lowering LDL oxidation, all blood markers, not clinical outcomes.

European journal of nutrition
Verbascoside/Oleuropein

Open-label trial, 2026

Olive extract supplementation was evaluated against blood pressure and cardiovascular health markers in adults. The indexed record does not state the allocation method, and oleuropein is named as a constituent of the extract rather than tested alone.

PLOS One
EPA (eicosapentaenoic acid)

Meta-analysis, 2026

Pooling high-dose EPA trials, the authors report that observed cardiovascular outcomes differed by the formulation studied rather than being uniform across preparations.

American Journal of Cardiovascular Drugs
Wild Fish Oil Concentrate

Meta-analysis, 2025

Across seven trials in 439 adults with elevated liver fat, fish oil moved triglycerides (standardised mean difference -0.40), the liver enzyme AST (-0.29), insulin resistance measured by HOMA-IR and waist circumference (-0.31) in a favourable direction, while ALT, GGT, body mass index and LDL cholesterol showed no detectable change.

Frontiers in Nutrition
Olive extract (fruit and leaf)

Randomised trial, 2022

The authors report improvements in inflammatory and glycaemic laboratory markers with extra virgin olive oil supplementation alongside a structured diet. These are markers, not clinical events.

Frontiers in Endocrinology
Verbascoside/Oleuropein

Randomised trial, 2025

Oleuropein supplementation raised resting skeletal muscle pyruvate dehydrogenase activity, a metabolic marker, and the trial did not detect a change in the other outcomes measured.

The Journal of Nutrition
Hydroxytyrosol/Tyrosol

Randomised trial, 2025

Hydroxytyrosol supplementation improved antioxidant and inflammatory marker readings in adults carrying excess body weight compared with placebo. Markers, not outcomes.

Clinical Nutrition
EPA (eicosapentaenoic acid)

Meta-analysis, 2026

Pooled trials found that the EPA to DHA ratio of a supplement shapes which fatty acids rise in the blood, with higher EPA shares linked to larger falls in circulating inflammatory markers, which are blood measures rather than outcomes.

Critical reviews in food science and nutrition
DHA (docosahexaenoic acid)

Systematic review, 2025

The review found that supplementation raised blood DHA status in people following a long-term protein-restricted diet, with the authors describing the functional outcome evidence as limited.

Frontiers in Nutrition
EPA (eicosapentaenoic acid)

Meta-analysis, 2021

In head to head and network comparisons of 20 randomised trials, EPA and DHA moved C-reactive protein, interleukin-6 and TNF-alpha to a similar degree, with no difference detected between the two.

Advances in Nutrition
Polyphenols

Meta-analysis, 2026

Pooled human trials examined how polyphenol supplementation changes gut bacterial composition and the short-chain fatty acids measured in stool.

Nutrients
Olive extract (fruit and leaf)

Randomised trial, 2026

A trial combining a Mediterranean-style diet with extra virgin olive oil found shifts in gut bacteria makeup, a compositional marker.

Life
Olive extract (fruit and leaf)

Systematic review, 2025

Across the human consumption studies reviewed, extra virgin olive oil intake was linked to lower liver fat and improved liver enzyme measures in adults with elevated liver fat.

Nutrients
DHA (docosahexaenoic acid)

Meta-analysis, 2026

A pooled analysis of trials of combined EPA and DHA supplementation reporting change in itch severity scores, a patient-reported measure.

Pharmaceuticals
DHA (docosahexaenoic acid)

Meta-analysis, 2026

Pooling trials of DHA taken during pregnancy, the review found only small and inconsistent differences in later child neurodevelopmental scores.

Developmental psychobiology
Wild Fish Oil Concentrate

Meta-analysis, 2024

Pooling 15 trials in pregnant women, fish oil capsules showed no detectable difference from placebo in blood sugar or blood lipid measures overall, with a lower HOMA-IR (mean difference -0.60) in the subgroup taking under 200 mg of EPA.

Nutrition Reviews
DHA (docosahexaenoic acid)

Meta-analysis, 2024

Across nine randomised trials, 450 to 800 mg a day of DHA in the second half of pregnancy was linked to infant birth weight about 102 g higher, with no difference detected in gestation length.

Nutrition Research

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people15 human studies on Wild Fish Oil Concentrate back this formula, each one cited.
  • A mechanism that is settledHow Wild Fish Oil Concentrate and EPA (eicosapentaenoic acid) work is settled pharmacology.
  • Studied together, not just separatelyDHA (docosahexaenoic acid) and Wild Fish Oil Concentrate have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2021.
  • Why this formatIt is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.
  • The exact form, describedThe label names its forms exactly: Triglyceride (natural), EPA ethyl ester, Triglyceride-form DHA oil. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeWild Fish Oil Concentrate is made by animal.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Wild Fish Oil Concentrateabout 4 to 8 weeks in blood plasma, about 6 months in red blood cellsBuilds with daily use

    In the trial record, EPA in blood plasma plateaus after 4 to 8 weeks of daily fish oil, while EPA in the red blood cell membrane rises with a 28 day half-life and reaches a steady state at about 180 days.

    Promising
  • Wild Fish Oil Concentrateabout eight weeks of daily useBuilds with daily use

    In a randomised single-blind trial, 20 participants took either fish oil supplying 1,296 mg EPA and 864 mg DHA daily or flaxseed oil for eight weeks, with erythrocyte membrane and plasma samples drawn at weeks 0, 4, 8, 10, 12, 14, 16 and 24. On fish oil, erythrocyte membrane EPA rose 300 percent and DHA rose 42 percent by week eight. Levels held until about week 12 and then declined across the post-supplementation sampling, faster in plasma phospholipids than in erythrocyte membranes. Membrane fatty acid content was measured, not a symptom, and this is one trial of 20 people.

    Cao et al., 2006PMID 17053155
    Promising
  • DHA (docosahexaenoic acid)about five to seven days of daily useBuilds with daily use

    In a randomised double-blind crossover trial, healthy men and women aged 19 to 34 took capsules supplying about 4 g DHA per day, with plasma sampled at days 0, 1, 3, 7, 14 and 28. DHA concentrations tripled and so did DHA-derived oxylipins. Increases were detectable as early as day 1, and 11 of 12 individual DHA oxylipins plus total DHA oxylipins reached a plateau by days 5 to 7. The plateau came earlier and was reached by more oxylipins in females than in males. Plasma marker chemistry was measured, not a feeling.

    Gabbs et al., 2021PMID 33097936
    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

8 ingredients, from each one's own page.

  • Wild Fish Oil Concentrate

    Membrane incorporation takes weeks. An omega-3 index blood test starts moving by about four weeks and settles across three to four months of daily use.

    Its own page, the plain answer on timing

  • EPA (eicosapentaenoic acid)Weeks, not days

    EPA has to work its way into cell membranes, and an omega 3 index blood test picks up most of the change by weeks eight to twelve of daily use.

    Its own page, the plain answer on timing

  • DHA (docosahexaenoic acid)About eight to twelve weeks

    Red blood cell omega-3 levels climb over roughly eight to twelve weeks of steady daily intake. That is where the change shows up, on a fatty acid panel rather than as a sensation.

    Its own page, the plain answer on timing

  • Olive extract (fruit and leaf)

    In a capsule it works from the first dose, carrying fat-soluble nutrients into micelles. Blood panel changes take three to six weeks of food-level daily intake.

    Its own page, the plain answer on timing

  • PolyphenolsWithin hours

    Blood-flow measures shift within hours of a single serving in laboratory settings. The changes you might notice in digestion and skin build across four to twelve weeks.

    Its own page, the plain answer on timing

  • Hydroxytyrosol/Tyrosol

    It runs on a marker timeline rather than a felt one. Trials pick up changes in oxidation markers after roughly three weeks of daily use.

    Its own page, the plain answer on timing

2 more
  • Verbascoside/OleuropeinAbout four to eight weeks

    Blood pressure and oxidative stress markers in trials shift across four to eight weeks of daily use. That's a change you read on a panel rather than notice hour to hour.

    Its own page, the plain answer on timing

  • Sesame seed lignan extract

    Marker changes in trials are read over weeks, typically four to eight. As a cooking oil it does its work quietly from the first meal.

    Its own page, the plain answer on timing

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Format

Softgel

It is a softgel, so the active is already dissolved in oil and the shell keeps it away from air and light.

Best forFat-soluble actives and oils: vitamin D, vitamin E, omega-3, CoQ10.
Recurring supply suggested

Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.

Questions shoppers ask

Is Super Omega-3 independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Super Omega-3?
Super Omega-3 is built on Wild Fish Oil Concentrate, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), Olive extract (fruit and leaf), Polyphenols, Hydroxytyrosol/Tyrosol, and more. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 631 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by Life ExtensionWork at Life Extension? This verification is yours to claim →