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Verified by IngredientMD/Mdrive/Boost and Burn
VERIFIED BYingredientMD

Boost and Burn.

Stronger in a pairMdrive, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Mdrive.

Chromax Chromium Picolinate is the lead active here, studied most for healthy insulin response. 13 human studies on Chromax Chromium Picolinate back this formula, each one cited. Each serving carries 200 mcg of Chromax Chromium Picolinate, inside the range the published research used. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
5Active ingredientsWell studiedResearch base55Human studies
Boost and BurnVerified by IngredientMD
MdriveIngredientMD
The verdict
Stronger in a pair
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
KSM-66 Ashwagandha: StrengthExtensively studied
Chromax Chromium Picolinate: Healthy insulin responseKey driver
Advantra Z Bitter Orange: Everyday calorie burnSupporting role
Caffeine: Everyday calorie burnExtensively studied
Cordyceps: EnduranceWell studied

How we read this product

Source: Supplement facts
Supplement Facts panel for Boost and Burn
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 5 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Stronger in a pair".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
55
Human studies
200 mcg
Chromax Chromium Picolinate
300 mg
KSM-66 Ashwagandha
300 mg per serving sits inside the studied 300 mg-600 mg range
KSM-66 Ashwagandha, Chandrasekhar 2012 + Lopresti 2019 meta-analysis
200 mcg per serving sits inside the studied 25 mcg-200 mcg range
Chromax Chromium Picolinate, NIH ODS + Cefalu 2010 review
100 mg per serving sits inside the studied 50 mg-200 mg range
Caffeine, EFSA 2015 caffeine safety + Goldstein 2010 review

Cross-checked against 715 documented interactions for these actives.

Read the evidenceKSM-66 Ashwagandha, the evidence →Chromax Chromium Picolinate, the evidence →Advantra Z Bitter Orange, the evidence →Caffeine, the evidence →Cordyceps, the evidence →

Inside the formula

KSM-66 Ashwagandha
14 studies
Strength
Extensively studied
Chromax Chromium Picolinate
13 studies
Healthy insulin response
Studied 25 mcg to 500 mcg a day
Key driver
Advantra Z Bitter Orange
Everyday calorie burn
Supporting role
Caffeine
17 studies
Everyday calorie burn
Studied 50 mg to 400 mg a day
Extensively studied
Cordyceps
Endurance
Well studied
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork March 13 to 27, 2025

15% of US adults

reported following a calorie-counting eating pattern in the past year, in the International Food Information Council's 2025 Food and Health Survey.

International Food Information Council, 2026
The people it speaks toFieldwork March 13 to 27, 2025

75% of US adults

said they were trying to limit or avoid sugar in their diet, in the International Food Information Council's 2025 Food and Health Survey.

International Food Information Council, 2026
This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
23 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Caffeine

Systematic review and meta-analysis, 2018

Across 46 trials, moderate caffeine doses of 3 to 6 mg per kg shortened endurance time-trial times by about 2.2 percent and raised power output by about 3 percent.

Sports Medicine
Caffeine

Meta-analysis, 2025

Pooled trials in volleyball players found better performance on jump and sport-specific tests after caffeine than after placebo.

Nutrients
Caffeine

Meta-analysis, 2026

Pooled trials in rugby players found that a single caffeine dose improved various physical performance measures specific to the sport.

Frontiers in Nutrition
Advantra Z Bitter Orange

Randomised trial, 2015

In resistance-trained adults, p-synephrine taken alone and with caffeine increased the total number of repetitions completed during a resistance exercise session without raising perceived exertion.

Journal of the International Society of Sport
KSM-66 Ashwagandha

Systematic review, 2014

An early review of human trials found ashwagandha root extract lowered self-reported stress and tension scores relative to placebo, though the trials were small and varied in method.

Journal of alternative and complementary medicine
Caffeine

Systematic review and meta-analysis, 2018

Caffeine produced a small increase in maximal muscle strength (standardized mean difference 0.20) and muscle power (0.17) over placebo, pooled across ten strength trials and ten power trials.

Journal of the International Society of Sports Nutrition
Caffeine

Systematic review and meta-analysis, 2010

Caffeine improved orientation and attention (standardized mean difference 0.55) and reduced errors on cognitive tests versus placebo, in a Cochrane review of 13 randomized trials in shift workers.

Cochrane Database of Systematic Reviews
Advantra Z Bitter Orange

Review, 2016

A review of thermogenic ingredients reported that p-synephrine from bitter orange raises resting energy expenditure modestly at commonly used doses, and the human studies reviewed did not report consistent changes in cardiovascular measures.

Phytotherapy research : PTR
KSM-66 Ashwagandha

Meta-analysis, 2020

Pooling controlled trials, ashwagandha supplementation was associated with a higher maximal oxygen uptake in both athletes and healthy adults.

Nutrients
Chromax Chromium Picolinate

Systematic review, 2013

In a Cochrane review of 9 randomized trials in overweight adults, chromium picolinate was associated with a modest average weight reduction of about 1.1 kg over 12 to 16 weeks, an effect the reviewers rated low-certainty and of debatable clinical relevance.

Cochrane Database of Systematic Reviews
KSM-66 Ashwagandha

Meta-analysis, 2024

Across nine randomised trials in 558 adults, ashwagandha formulations lowered perceived stress scale scores by about 4.7 points and lowered serum cortisol compared with placebo.

Explore
Chromax Chromium Picolinate

Meta-analysis, 2024

Across 14 trials in adults with elevated blood sugar, chromium did not measurably change body weight, BMI, waist size or fat mass overall, with a fat drop only in older adults on picolinate form.

Journal of Trace Element Medicine and Biology
Chromax Chromium Picolinate

Meta-analysis, 2025

Across 20 trials in adults carrying excess weight, chromium lowered fasting insulin by about 12.6 pmol/L and an insulin resistance marker by about 0.26, without a significant change in fasting glucose.

Journal of Trace Element Medicine and Biology
Advantra Z Bitter Orange

Randomised trial, 2011

Acute intake of a multi-ingredient herbal preparation was assessed for blood pressure and heart rate response, with the bitter orange component named within the blend rather than tested alone.

International journal of medical sciences
KSM-66 Ashwagandha

Meta-analysis, 2021

Pooling five randomised trials in 400 adults, ashwagandha extract produced a small improvement in overall sleep (standardised mean difference 0.59), most prominent at 600 mg a day or more taken for at least eight weeks.

PLoS One
KSM-66 Ashwagandha

Systematic review, 2021

Among the herbs reviewed for effects on testosterone in men, ashwagandha had the most supportive human data, with several trials reporting higher circulating testosterone versus placebo.

Advances in nutrition
Chromax Chromium Picolinate

Meta-analysis, 2021

Pooling 24 randomized trials in adults with high blood sugar, chromium supplementation was linked to small reductions in triglycerides (about 6.5 mg/dL) and total cholesterol (about 7.8 mg/dL) and a small rise in HDL cholesterol (about 2.2 mg/dL), effects the authors described as small and possibly below clinical importance.

Journal of Trace Elements in Medicine and Biology

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people17 human studies on Caffeine back this formula, each one cited.
  • A mechanism that is settledHow KSM-66 Ashwagandha and Chromax Chromium Picolinate work is settled pharmacology.
  • Studied together, not just separatelyKSM-66 Ashwagandha and Caffeine have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2026.
  • Serving amount inside the studied rangeEach serving carries 200 mcg of Chromax Chromium Picolinate, inside the range the published research used.
  • A stated daily maintenance amountChromax Chromium Picolinate is here at a daily maintenance amount, which is what a daily supplement is for.
  • Why this formatIt is a capsule, so the amount per serving is fixed and travels without measuring.
  • The exact form, describedThe label names its forms exactly: Root extract powder standardised to withanolide glycosides, Chromium picolinate, Citrus aurantium peel powder. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeKSM-66 Ashwagandha is made by botanical.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • KSM-66 Ashwagandhaabout eight to nine weeks of daily useBuilds with daily use

    In a 60 day randomised, double-blind, placebo-controlled trial, 60 stressed healthy adults took 240 mg of a standardised ashwagandha extract (Shoden) once daily or placebo. The ashwagandha arm showed a larger fall in Hamilton Anxiety Rating Scale scores (p = .040) and in morning cortisol (p < .001) than placebo, with the DASS-21 change near-significant (p = .096). A separate 8 week randomised, double-blind, placebo-controlled dose-ranging trial enrolled 131 adults with self-reported high stress and analysed 98, measuring reduced Perceived Stress Scale scores at 125, 250 and 500 mg per day of an aqueous root and leaf extract. Two trials on two different extracts, both landing in the same eight to nine week band.

    Promising
  • Caffeinewithin about 45 to 60 minutes of a single doseMeasured within a day

    In a double-blind placebo-controlled crossover trial, 15 resistance-trained women took 4 mg per kg body mass of caffeine 60 minutes before a strength and power battery. Squat one-repetition maximum rose 4.5 percent and countermovement jump height 7.6 percent against placebo. A separate crossover trial in 11 active adults began its cycling tests 45 minutes after a 3 mg per kg capsule and recorded a peak-power increase of about 4 percent on the first day of ingestion.

    Norum et al., 2020PMID 32681596
    Lara et al., 2019PMID 30673725
    Promising
  • Caffeineheld for about 15 to 18 days of daily use, then narrowedBuilds with daily use

    One crossover trial mapped the day-to-day time course in 11 healthy active adults taking 3 mg per kg per day for 20 consecutive days. Peak cycling power in the incremental test stayed about 4.0 percent above placebo for the first 15 days and the difference then lessened. Wingate peak power was still raised on days 1, 4, 15 and 18 by about 4.9 percent. The authors describe the shrinking margin as progressive tolerance. This is one trial with 11 participants.

    Lara et al., 2019PMID 30673725
    Early
  • Cordycepswithin the hour of a single doseMeasured within a day

    In a randomised, double-blind, placebo-controlled crossover in 12 recreationally active young men, a single 1 g dose of standardised Cordyceps militaris extract taken 30 minutes before a maximal cycling test was followed by faster Stroop reaction times across the session compared with placebo.

    Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

Five ingredients, from each one's own page.

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Chemical form

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

  • Chromium picolinate

    A neutral coordination complex of trivalent chromium bound to three picolinic acid ligands. Picolinic acid is the same molecule the body forms from tryptophan, here acting as the carrier around a single chromium centre.

    Fits
    The most widely used chromium form in retail supplements. A stable, well-characterised complex that works in dry capsules, tablets and powders and supplies chromium at the microgram doses typical of the category.
    Trade-off
    The picolinate ligand has drawn research scrutiny over its redox behaviour at high intake in laboratory work, and it is a distinct synthesised molecule rather than the chromium as it occurs in food.

    In a six-month double-blind, placebo-controlled pilot trial in 24 overweight adults with binge eating disorder, chromium picolinate at 600 or 1000 micrograms per day was associated with lower fasting glucose than placebo, with a larger reduction in the higher-dose group. Fasting glucose is a metabolic marker, not a clinical endpoint.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Format

Capsule

It is a capsule, so the amount per serving is fixed and travels without measuring.

Best forMost standard doses, and anywhere a short, clean label is the point.

Questions shoppers ask

Is Boost and Burn independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Boost and Burn?
Boost and Burn is built on KSM-66 Ashwagandha, Chromax Chromium Picolinate, Advantra Z Bitter Orange, Caffeine, Cordyceps. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 715 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

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