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Verified by IngredientMD/Natural Vitality/CALM Magnesium
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CALM Magnesium.

Strong evidence, strong doseNatural Vitality, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Natural Vitality.

Magnesium is the lead active here, studied most for calm and steady mood. 21 human studies on Magnesium back this formula, each one cited. Each serving carries 290 mg of Vitamin C, inside the range the published research used. Who it fits: skews toward women, adults.

Clinically dosedFull label disclosure
5Active ingredientsWell studiedResearch base87Human studies
CALM MagnesiumVerified by IngredientMD
Natural VitalityIngredientMD
The verdict
Strong evidence, strong dose
For Skews toward women, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Vitamin C: Collagen and connective tissueExtensively studied
Vitamin D: Mood that holds through the weekExtensively studied
Calcium: Bone strengthExtensively studied
Magnesium: Calm and steady moodKey driver
Potassium: Electrolyte balanceExtensively studied

How we read this product

Source: Supplement facts
Supplement Facts panel for CALM Magnesium
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 5 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
87
Human studies
350 mg
Magnesium
290 mg
Vitamin C
290 mg per serving sits inside the studied 200 mg-500 mg range
Vitamin C, Levine 1996 pharmacokinetics + NIH ODS
350 mg per serving sits inside the studied 200 mg-400 mg range
Magnesium, NIH Office of Dietary Supplements + Rosanoff 2012 meta-analysis

Cross-checked against 2,435 documented interactions for these actives.

Read the evidenceVitamin C, the evidence →Vitamin D, the evidence →Calcium, the evidence →Magnesium, the evidence →Potassium, the evidence →

Inside the formula

Vitamin C
20 studies
Collagen and connective tissue
Studied 200 mg to 1 g a day
Extensively studied
Vitamin D
17 studies
Mood that holds through the week
Extensively studied
Calcium
13 studies
Bone strength
Extensively studied
Magnesium
21 studies
Calm and steady mood
Studied 200 mg to 600 mg a day
Key driver
Potassium
16 studies
Electrolyte balance
Extensively studied
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2024

12% of US adults

regularly reported feelings of worry, nervousness, and anxiety in 2024, in the National Health Interview Survey.

CDC National Center for Health Statistics, 2024
21 more
The people it speaks to

39% of adults worldwide

said they worried a lot the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.

Gallup, 2024
The people it speaks to

37% of adults worldwide

said they felt stressed the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.

Gallup, 2024
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Magnesium

Randomised trial, 2012

In 46 older adults with poor sleep, eight weeks of magnesium improved their scores on a sleep questionnaire against placebo.

older adults with poor sleep
Magnesium

Randomised trial, 2026

In one trial, 20 adults on an antidepressant added magnesium, and low mood scores changed over six weeks, with the antidepressant doing part of the work by design.

East Asian Archives of Psychiatry
Magnesium

Systematic review, 2024

Across exercise studies, magnesium was linked to less muscle soreness and better recovery, with people training hard possibly needing 10 to 20 percent more than sedentary people.

Journal of Translational Medicine
Vitamin C

Randomised trial, 2026

In repeated single-person trials, vitamin C raised blood levels by 20.6 micromol/L and lowered two stress markers, with day-to-day swings bigger than differences between people.

Free Radical Biology and Medicine
Magnesium

Meta-analysis, 2025

Across over 20 trials, magnesium raised HDL cholesterol by about 1.2 mg/dL but showed no clear change in LDL, total cholesterol or triglycerides.

Nutrition Journal
Vitamin C

Meta-analysis, 2011

Across 13 trials, about 500 mg of vitamin C daily lowered blood uric acid by roughly 0.35 mg/dL.

The paper
Vitamin C

Meta-analysis, 2014

Across 44 trials, vitamin C improved how well the blood vessel lining widens, a moderate effect of 0.50, larger at higher doses.

The paper
Ashor et al., 2014PMID 24792921
Vitamin D

Meta-analysis, 2014

Pooling 30 randomised trials in 5,615 adults averaging 61 years, vitamin D produced a small increase in overall muscle strength (standardised mean difference 0.17), with no detectable change in muscle mass or muscle power.

The Journal of Clinical Endocrinology and Metabolism
Vitamin C

Meta-analysis, 2012

Pooling 29 randomized trials, vitamin C at a median of 500 mg a day lowered systolic blood pressure by about 3.8 mmHg and diastolic by about 1.5 mmHg over a median of eight weeks.

American Journal of Clinical Nutrition
Vitamin D

Meta-analysis, 2026

A review re-examined trials of vitamin D against heart and blood vessel outcomes, questioning how they were analyzed and what the combined result actually supports.

European Journal of Epidemiology
Vitamin D

Meta-analysis, 2026

A review of reviews found vitamin D lowered blood inflammation markers, generally by a small amount.

Inflammopharmacology
Vitamin D

Meta-analysis, 2022

Across 13 randomised trials in women after midlife, vitamin D raised handgrip strength by about 0.88 kg, while a timed get-up-and-go mobility test showed no detectable difference.

Frontiers in Endocrinology
Vitamin D

Systematic review, 2022

Across 13 randomised trials in adults carrying several metabolic risk factors, vitamin D raised serum 25-hydroxyvitamin D levels and lowered fasting blood sugar, fasting insulin and an insulin-resistance index, with no detectable change in cholesterol or triglycerides. The authors call the overall picture inconclusive.

Frontiers in Pharmacology
Vitamin D

Meta-analysis, 2026

A review combined trials of vitamin D given to adults in intensive care and looked at survival, though the trials varied widely in dose, route and starting vitamin D status.

Frontiers in Nutrition

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people21 human studies on Magnesium back this formula, each one cited.
  • A mechanism that is settledHow Vitamin C and Vitamin D work is settled pharmacology.
  • Studied together, not just separatelyVitamin C and Calcium have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2026.
  • Serving amount inside the studied rangeEach serving carries 290 mg of Vitamin C, inside the range the published research used.
  • A stated daily maintenance amountVitamin C is here at a daily maintenance amount, which is what a daily supplement is for.
  • Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
  • The exact form, describedThe label names its forms exactly: Ascorbic acid, Ergocalciferol (vitamin D2), Calcium carbonate. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeVitamin C is made by fermentation.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
  • Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.
Studied together

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

  • Calcium + MagnesiumStrength

    In a 12-month randomised, double-blind trial, 98 adults aged 50 and over drank a litre a day of either a naturally calcium- and magnesium-rich mineral water or a low-mineral water. The mineral-rich group had fewer falls at the 6-month assessment and higher appendicular muscle mass, with the minerals delivered as drinking water rather than a capsule.

    Promising

Research strength. Research strength says how much work stands behind the combination. It is never a product score.

Fail closed. Where actives were studied on their own rather than together, each shows on its own evidence, never a combined effect no trial measured.

Independent record. Every finding is cited to a named trial, dated, and never written by the brand.

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

How much it moves the numbers

The size of the effect, in plain numbers.

Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.

Vitamin Crisk of developing a cold
Average change in the trials

About 52 percent lower risk of developing a cold, in trials of people undergoing brief periods of severe physical exertion.

Measured in
marathon runners, skiers and soldiers on subarctic exercises
Confidence interval
risk ratio 0.48, 95% CI 0.35 to 0.64
Magnesiumsystolic blood pressure
Average change in the trials

About 2 mmHg lower systolic and 1.8 mmHg lower diastolic, on average across the trials.

Measured in
adults, at a median 368 mg per day for about 3 months
Confidence interval
systolic 0.4 to 3.6 mmHg lower

Read at the source. The magnitude sits beside the same trial the claim already cites. It describes what the trials measured, never what any one person will feel.

What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Vitamin Cwithin 24 hours of a single doseMeasured within a day

    In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.

    Strong
  • Vitamin Dabout 3 months of daily useBuilds with daily use

    In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

    Early
  • Calciumwithin about one to six hours of a single doseMeasured within a day

    A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.

    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

Five ingredients, from each one's own page.

  • Vitamin CWithin hours

    Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.

    Its own page, the plain answer on timing

  • Vitamin DAbout six to twelve weeks

    25-hydroxyvitamin D climbs steadily over six to twelve weeks of daily use. That blood measurement is where the change shows up, rather than in a day-one sensation.

    Its own page, the plain answer on timing

  • Calcium

    No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.

    Its own page, the plain answer on timing

  • Magnesium

    A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.

    Its own page, the plain answer on timing

  • Potassium

    Cramp steadiness and hydration can shift within a day or two of raising intake. The blood pressure side, within the normal range, reads out over four to six weeks.

    Its own page, the plain answer on timing

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Format

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.

Best forGram-scale actives: creatine, collagen, protein, electrolytes, beta-alanine.
From the same shelf

Studied alongside this brand's other formulas

Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.

Questions shoppers ask

Is CALM Magnesium independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in CALM Magnesium?
CALM Magnesium is built on Vitamin C, Vitamin D, Calcium, Magnesium, Potassium. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 2,435 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by Natural VitalityWork at Natural Vitality? This verification is yours to claim →