About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisMagnesium is the lead active here, studied most for calm and steady mood. 21 human studies on Magnesium back this formula, each one cited. Each serving carries 290 mg of Vitamin C, inside the range the published research used. Who it fits: skews toward women, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 5 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 2,435 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisAbout 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisAbout 42% of Americans
take in less calcium than the estimated average requirement.
NHANESAbout 48% of Americans
take in less magnesium than recommended from food and drink.
NIH Office of Dietary SupplementsMore than 1 in 3 US adults
regularly sleep less than the recommended seven hours a night.
Peer-reviewed analysis12% of US adults
regularly reported feelings of worry, nervousness, and anxiety in 2024, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202439% of adults worldwide
said they worried a lot the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.
Gallup, 202437% of adults worldwide
said they felt stressed the previous day, in the Gallup World Poll fielded in 2024 across 144 countries and territories.
Gallup, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health Statistics59 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Systematic review, 2021
Across 3 trials in older adults, it shortened the time to fall asleep by about 17 minutes.
BMC Complement Med TherRandomised trial, 2012
In 46 older adults with poor sleep, eight weeks of magnesium improved their scores on a sleep questionnaire against placebo.
older adults with poor sleepRandomised trial, 2026
In one trial, 20 adults on an antidepressant added magnesium, and low mood scores changed over six weeks, with the antidepressant doing part of the work by design.
East Asian Archives of PsychiatrySystematic review, 2024
Across exercise studies, magnesium was linked to less muscle soreness and better recovery, with people training hard possibly needing 10 to 20 percent more than sedentary people.
Journal of Translational MedicineControlled clinical trial, 2004
Adding vitamin C to an iron-fortified meal at a 4 to 1 ratio with iron raised non-heme iron absorption about 2.9-fold, from 4.1% to 11.7%.
American Journal of Clinical NutritionRandomised trial, 2026
In repeated single-person trials, vitamin C raised blood levels by 20.6 micromol/L and lowered two stress markers, with day-to-day swings bigger than differences between people.
Free Radical Biology and MedicineMeta-analysis, 2025
Across over 20 trials, magnesium raised HDL cholesterol by about 1.2 mg/dL but showed no clear change in LDL, total cholesterol or triglycerides.
Nutrition JournalMeta-analysis, 2011
Across 13 trials, about 500 mg of vitamin C daily lowered blood uric acid by roughly 0.35 mg/dL.
The paperMeta-analysis, 2014
Across 44 trials, vitamin C improved how well the blood vessel lining widens, a moderate effect of 0.50, larger at higher doses.
The paperMeta-analysis, 2014
Pooling 30 randomised trials in 5,615 adults averaging 61 years, vitamin D produced a small increase in overall muscle strength (standardised mean difference 0.17), with no detectable change in muscle mass or muscle power.
The Journal of Clinical Endocrinology and MetabolismMeta-analysis, 2012
Pooling 29 randomized trials, vitamin C at a median of 500 mg a day lowered systolic blood pressure by about 3.8 mmHg and diastolic by about 1.5 mmHg over a median of eight weeks.
American Journal of Clinical NutritionMeta-analysis, 2026
A review re-examined trials of vitamin D against heart and blood vessel outcomes, questioning how they were analyzed and what the combined result actually supports.
European Journal of EpidemiologyMeta-analysis, 2026
A review of reviews found vitamin D lowered blood inflammation markers, generally by a small amount.
InflammopharmacologyMeta-analysis, 2022
Across 13 randomised trials in women after midlife, vitamin D raised handgrip strength by about 0.88 kg, while a timed get-up-and-go mobility test showed no detectable difference.
Frontiers in EndocrinologySystematic review, 2022
Across 13 randomised trials in adults carrying several metabolic risk factors, vitamin D raised serum 25-hydroxyvitamin D levels and lowered fasting blood sugar, fasting insulin and an insulin-resistance index, with no detectable change in cholesterol or triglycerides. The authors call the overall picture inconclusive.
Frontiers in PharmacologyMeta-analysis, 2026
A review combined trials of vitamin D given to adults in intensive care and looked at survival, though the trials varied widely in dose, route and starting vitamin D status.
Frontiers in NutritionPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.
In a 12-month randomised, double-blind trial, 98 adults aged 50 and over drank a litre a day of either a naturally calcium- and magnesium-rich mineral water or a low-mineral water. The mineral-rich group had fewer falls at the 6-month assessment and higher appendicular muscle mass, with the minerals delivered as drinking water rather than a capsule.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Fail closed. Where actives were studied on their own rather than together, each shows on its own evidence, never a combined effect no trial measured.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.
Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.
About 52 percent lower risk of developing a cold, in trials of people undergoing brief periods of severe physical exertion.
About 2 mmHg lower systolic and 1.8 mmHg lower diastolic, on average across the trials.
Read at the source. The magnitude sits beside the same trial the claim already cites. It describes what the trials measured, never what any one person will feel.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.
In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.
A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
Five ingredients, from each one's own page.
Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.
25-hydroxyvitamin D climbs steadily over six to twelve weeks of daily use. That blood measurement is where the change shows up, rather than in a day-one sensation.
No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.
A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.
Cramp steadiness and hydration can shift within a day or two of raising intake. The blood pressure side, within the normal range, reads out over four to six weeks.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.
D3 absorbs calcium, K2 directs it to bones, Mg activates D3. The complete calcium optimization system.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.