About 42% of Americans
take in less calcium than the estimated average requirement.
NHANESIron is the lead active here, studied most for oxygen delivery to working muscle. 17 human studies on Iron back this formula, each one cited. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 9 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Backed by human trials".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 1,879 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 42% of Americans
take in less calcium than the estimated average requirement.
NHANES24.2% of US adults
aged 18 and over met both the aerobic and muscle strengthening activity guidelines in 2020, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202231% of US adults
said they were taking protein supplements such as powders, drinks, or bars, in a Pew Research Center survey fielded in July 2026.
Pew Research Center, 202621.1% of the US population
aged 15 and over took part in sports, exercise, or recreation on an average day in 2023, in the American Time Use Survey.
US Bureau of Labor Statistics, 202457.6%
During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.
CDC National Center for Health StatisticsAbout 10% of US women of reproductive age
are iron deficient.
Peer-reviewed analysis41.3% of US men aged 18 to 34
met both the aerobic and muscle strengthening activity guidelines in 2020, the highest rate of any age and sex group, in the National Health Interview Survey.
CDC National Center for Health Statistics, 202237% of US adults aged 18 to 29
said they were taking protein supplements such as powders, drinks, or bars, roughly double the rate among adults aged 65 and over, in a Pew Research Center survey fielded in July 2026.
Pew Research Center, 202659 to 66 days
was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.
Systematic review and meta-analysis, 202461% to 74%
About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.
Cohort study, 2015Meta-analysis, 2024
Pooling 26 studies in 1,439 adults, stevia intake lowered blood glucose by about 3.8 mg/dL on low-certainty evidence, with no detectable change in insulin or HbA1c.
The paperRandomised trial, 2023
In this trial, a single dose of microencapsulated cocoa blunted the temporary fall in a measure of blood vessel widening that follows hard eccentric exercise.
International journal of food sciences and nutritionRandomised trial, 2023
In 60 adults with excess weight, stevia drinks before a carb breakfast cut the two-hour insulin response versus sugar, with no detected difference in food intake over the next day.
AppetiteMeta-analysis, 2017
Across 185 studies, cutting sodium from about 201 to 66 mmol a day lowered systolic pressure by 1 mmHg in normal-reading adults and 5.5 mmHg in those with high readings.
Cochrane Database of Systematic ReviewsRandomised trial, 2001
In 412 adults, cutting sodium from high to low lowered systolic blood pressure by about 6.7 mmHg on a typical diet and about 3 mmHg on the DASH diet.
New England Journal of MedicineMeta-analysis, 2014
Across nine randomised trials in 756 adults, steviol glycosides produced small reductions in diastolic blood pressure and fasting blood glucose, while the systolic change of about 3 mmHg was not statistically distinguishable from placebo.
European Journal of Preventive CardiologyRandomised trial, 2026
Reports results for physical performance measures in participants randomised to cocoa extract supplementation within COSMOS.
JBMR PlusMeta-analysis, 2025
Pooling trials in healthy adults, dark chocolate intake was associated with a small change in peak oxygen uptake during exercise, and results varied across the individual trials.
Physiological reportsRandomised trial, 2024
In 53 adults with excess body weight, biscuits sweetened with stevia rebaudioside M instead of sucrose lowered the two-hour insulin and glucose responses, and appetite ratings were similar across all three versions.
EBioMedicineRandomised trial, 2024
In top-level athletes, short-term cocoa supplementation was accompanied by shifts in gut bacterial composition and in blood markers of lipid metabolism over the study period.
International journal of sport nutrition and exercise metabolismRandomised trial, 2025
A leucine-enriched beta-lactoglobulin preparation was compared with an isonitrogenous whey protein isolate for skeletal muscle protein synthesis, a stable-isotope marker measured over hours rather than a change in muscle size.
NutrientsSystematic review, 2026
Across the trials reviewed, whey and soy protein supplementation alongside resistance training in young adults was associated with changes in training adaptations, with the authors noting variability between studies.
Journal of Dietary SupplementsSystematic review, 2025
Supplementation with milk proteins was reviewed for effects on body composition and anthropometric measures, with results varying by the training and dietary context of the underlying trials.
NutrientsRandomised trial, 2020
Measured what added dietary salt did to sympathetic activity and endothelial function markers in a group showing salt-sensitive blood pressure responses. These are markers, not clinical outcomes.
The Journal of Clinical Endocrinology and MetabolismRandomised trial, 2026
Reports the effects of daily cocoa extract and multivitamin-multimineral supplementation on epigenetic ageing clock measures. Epigenetic clocks are surrogate markers, not clinical outcomes.
Nature MedicineSystematic review, 2026
Across trials of dietary flavonoids, cocoa among them, some studies reported better mood scores while the overall pattern of findings was inconsistent.
Nutrition reviewsMeta-analysis, 2024
Pooling randomised trials, nut intake was associated with small improvements on some cognitive test scores in adults.
Frontiers in nutritionSystematic review, 2025
Across the pooled trials the authors did not detect evidence supporting a restricted white diet, including avoidance of cola-type drinks, during dental bleaching. A failure to detect a difference is not proof that none exists.
Journal of DentistrySystematic review, 2026
Long-term plant and animal protein supplementation were compared for body composition, muscle strength and physical performance. The review did not detect a clear separation between the two sources, which is a failure to detect a difference rather than evidence that they perform identically.
Frontiers in NutritionRandomised trial, 2019
Whey protein isolate taken during endurance training did not produce a detectable change in cycling performance or the immune measures recorded, which is a failure to detect a difference and not evidence that none exists.
Frontiers in NutritionSystematic review, 2025
A review looked at early protein intake in infancy and later body weight and metabolic measures in children, finding associations across cohorts rather than a demonstrated cause.
The American Journal of Clinical NutritionMeta-analysis, 2013
Across 34 trials in 3,230 people, cutting salt by about 4.4 g a day lowered systolic blood pressure by about 4.2 mmHg and diastolic by about 2.1 mmHg.
Cochrane Database of Systematic ReviewsPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.
A randomised crossover study in 54 nonanemic young women with plasma ferritin at or below 20 ug/L gave labelled iron sulfate as single fasting morning doses of 40, 60, 80, 160 and 240 mg. Twenty four hours after doses of 60 mg or more, serum hepcidin was raised and fractional iron absorption from the following dose was 35% to 45% lower. Across the dose range a sixfold rise in dose, 40 to 240 mg, produced a threefold rise in iron absorbed, 6.7 to 18.1 mg. Total iron absorbed from three doses inside 24 hours was not significantly greater than from two morning doses. The measure was iron absorption and serum hepcidin, not a symptom.
In a randomised crossover trial, 12 healthy men aged 19 to 32 consumed 29.6 g of whey protein isolate, with plasma amino acids sampled at 30, 60, 90, 120 and 180 minutes after the dose. Essential amino acids, branched-chain amino acids and leucine all rose significantly from baseline in both arms. The trial's comparison was between a processed isolate and the standard form.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
9 ingredients, from each one's own page.
No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.
Before everyday stamina shifts. Ferritin, the storage marker, climbs over months of steady daily intake rather than days.
Cramp steadiness and hydration can shift within a day or two of raising intake. The blood pressure side, within the normal range, reads out over four to six weeks.
The amino acid rise happens inside an hour. Strength and lean mass changes are read at eight to twelve weeks in most trials, alongside resistance training.
Taste is immediate. The fat and protein register as mild fullness within about half an hour, and at these amounts there is nothing cumulative to wait on.
Vessel-function measures such as flow-mediated dilation shift within two to three hours of a single dose. Blood pressure readings settle over two to four weeks of daily use.
Caffeine peaks in blood 30 to 60 minutes in, so alertness lifts inside the hour. The theobromine behind it comes on slower and stays longer.
In an electrolyte drink after heavy sweating, within the hour. As a formulation ingredient it works on taste and texture, with no onset of its own.
The sweetness lands on the first sip. Anything beyond taste has only been studied with amounts far larger than a sweetener provides, read over one to two months.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.
Active vitamin D switches on the calcium-binding proteins and channels in the gut lining that carry calcium across the intestinal wall, so the body absorbs far more of the calcium it takes in. With too little vitamin D, much of a calcium dose passes straight through unabsorbed.
Established biochemistry. No combination trial has tested this exact pairing.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.