Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Aquilegia formosa has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Cyanogenic glycosides in columbine seed and root release small amounts of hydrogen cyanide when plant tissue is crushed or chewed. The body clears cyanide mainly through rhodanese, which needs a sulfur donor, and cysteine feeds that sulfur pool. This is background biochemistry about handling a plant constituent, not a reason to combine the two on purpose.
Hydroxocobalamin binds cyanide directly to form cyanocobalamin, which is why the cyano form of B12 exists at all. Any cyanogenic plant material sits at the far end of that same chemistry. The point here is mechanistic bookkeeping about the genus, and it says nothing about a dosing pair.
Columbine flowers and leaves contain flavonoids and tannin-type polyphenols, and that class binds non-heme iron in the gut lumen into complexes the intestine absorbs poorly. A strong infusion taken with an iron supplement or an iron-rich meal lowers how much of that iron gets across. Spacing the two by a couple of hours removes the overlap.
Ascorbate reduces ferric iron to the ferrous form and keeps it soluble, which partly offsets the iron binding that plant polyphenols cause. Taken in the same sitting, it narrows the gap rather than closing it. This is a general polyphenol rule applied to a polyphenol-containing herb, not a finding specific to this species.
Western columbine appears in flower infusions alongside other mild aromatic flowers such as chamomile. The pairing is culinary and traditional rather than pharmacological, and no controlled work has looked at the combination. Read it as blending practice.
Nothing specific on file for Aquilegia formosa. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.