Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Microcos has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Work in rodents has linked the GABA content of Microcos paniculata leaf to its activity in a seizure-threshold model, which places the plant on the same neurotransmitter axis as supplemental GABA. Whether orally taken GABA from either source crosses the blood-brain barrier in humans in useful amounts remains contested. The pairing is mechanistic and animal-derived. It is not human evidence for a combined effect.
L-theanine influences GABAergic and glutamatergic tone and is commonly used for a calm-alert state. Microcos leaf material has been characterised as carrying GABA and flavonoids with reported central activity in animals. If both are taken together, any drowsiness is likely to add rather than cancel. That matters for driving and machinery and is the reason to flag the pairing at all.
Magnesium is a physiological blocker at the NMDA receptor channel and a positive influence on GABA-A signalling, which is established receptor pharmacology independent of any botanical. Combining it with a plant characterised by GABA content puts two inputs on the same inhibitory system. The direction of any combined effect on alertness is downward, so evening dosing is the sensible placement.
Valerian constituents interact with GABA-A receptor sites and the plant is used for sleep onset. Microcos leaf sits on the same axis by way of its GABA content. Stacking two sedating botanicals raises the chance of next-morning grogginess more reliably than it raises benefit. Anyone taking a prescribed sedative should clear this pairing with a clinician first.
Microcos leaf carries a flavonoid and phenolic profile that has been characterised alongside its other constituents. Ascorbate regenerates oxidised flavonoid radicals back to their reduced form, which is standard antioxidant chemistry across polyphenol-bearing plants. This is a chemical relationship measured in solution. It has not been shown to change any clinical measure for this plant.
Nothing specific on file for Microcos. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 1 we read for Microcos. The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.