Cross-referencing clinical data
Oroxylum
- Category
- Herb
Nothing to show here, and the reason why.
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Oroxylum has none that clears that bar.
No pairing for Oroxylum has cleared review yet.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
Plays well withEstablished knowledge, not a trial
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Oroxylum + MCT OilFlavone aglycones such as baicalein and chrysin are poorly water soluble
Baicalein, chrysin and oroxylin A are lipophilic flavones with low aqueous solubility, which is a major limit on how much gets absorbed from a dry powder. Taking them with a fat containing meal or a lipid vehicle raises the dissolved fraction available for uptake. This is standard solubility chemistry rather than a special property of this plant. The size of the gain depends on the formulation.
Oroxylum + Sunflower LecithinPhospholipid complexation of poorly soluble flavonoids is an established formulation route
Phospholipid complexes and liposomal carriers are widely used to raise the bioavailability of lipophilic flavonoids, and the same chemistry applies to the Oroxylum flavones. Lecithin in a formulation acts as an emulsifier that keeps the flavone dispersed rather than settling out. This is a delivery mechanism, not an added activity. The pairing is formulation practice.
Oroxylum + Black Pepper Extract (Bioperine)Flavones are heavily glucuronidated, and piperine inhibits that pathway
Baicalein and chrysin are subject to extensive intestinal glucuronidation, which is the main reason oral chrysin shows such poor systemic exposure. Piperine inhibits UDP glucuronosyltransferases and has raised flavonoid exposure in animal work. Direct human data with Oroxylum is absent. Piperine also raises exposure to co administered medicines, which is a caution rather than a bonus.
Oroxylum + QuercetinBoth compete for the same conjugating enzymes and efflux transporters
Quercetin and the Oroxylum flavones are both substrates for UGT enzymes and for efflux transporters in the gut wall. Taken together in quantity they compete, which can raise exposure to one or both in a way that is hard to predict. Whether that is useful or a problem depends on what else is in the regimen. The direction is a real pharmacokinetic effect and the magnitude is unmeasured for this pair.
Oroxylum + GABAChrysin and baicalein bind the benzodiazepine site of GABA-A receptors in binding assays
Both chrysin and baicalein show affinity for the benzodiazepine binding site on GABA-A receptors in vitro, which is the mechanistic root of the calming reputation of this flavone family. Stacking with other agents aimed at GABAergic signalling can add on the drowsiness side. Oral GABA itself has poor central penetration, so the practical additive effect may be small. The receptor binding is laboratory work, not a demonstrated human sedative effect.
Oroxylum + Valerian RootOverlapping intent around evening calm, no combination data
Both are used in evening formulations and both are proposed to act somewhere around GABAergic signalling. Two sedating botanicals together mean more next morning heaviness for some people. No controlled work has tested this pair. Start with one before adding the other.
Oroxylum + Curcumin (Turmeric)Competition for the same intestinal conjugation capacity
Curcumin and the Oroxylum flavones are both cleared largely by glucuronidation in the gut wall and liver. Taken in quantity at the same time they draw on the same finite conjugating capacity, which can raise circulating levels of either. Both are also often sold with piperine, which compounds the effect. This is a pharmacokinetic caution rather than a synergy to seek out.
Who should be cautious
Nothing specific on file for Oroxylum. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.The forms it comes in.
Oroxylum bark, dried and milledWhole dried bark, flavones present as the natural glycoside and aglycone mixtureFits Traditional decoctions and preparations where whole plant material is intendedTrade-off Flavone content varies widely with source and harvest, and the lipophilic aglycones dissolve poorly from a dry powder. Dose per serving is not repeatable.
Oroxylum indicum extract, baicalein standardisedHydroethanolic extract concentrated to a stated baicalein or total flavone percentageFits Capsule products where a repeatable flavone dose is the requirementTrade-off Standardising to one marker says nothing about the others, and baicalein and chrysin behave differently on absorption. Two extracts at the same stated percentage may not deliver the same exposure.
Oroxylum seed extractSeed derived material, flavone profile differs from bark with different relative chrysin contentFits Products built specifically around the seed constituent profileTrade-off Seed and bark are separate inputs and literature on one does not transfer to the other. Labels often say Oroxylum indicum without naming the part.
Oroxylum pod as vegetableFresh immature pod, eaten grilled or in salads across Thailand, Laos and northeast IndiaFits Food use rather than supplementationTrade-off Nothing about the flavone dose from a culinary portion is characterised, and it is far from an extract level intake. This is a food, and the food and supplement literatures should not be blended.
What the strongest studies found
The essence, in one line each.
- Oroxylum indicum extract reduced memory deficits and increased hippocampal neurogenesis markers in a rat aging model induced by D-galactose.Animal study. Tanrangka et al., 2025 (Scientific Reports). PMID 41330961 ↗
- Oroxylum indicum extract protected cultured neuronal cells against a stress challenge, with the authors attributing the effect to upregulation of protective signalling pathways.In vitro study. Sreedharan et al., 2024 (Nutrients). PMID 38931243 ↗
These are the studies our verdict leans on, chosen from the 2 we read for Oroxylum. The full linked list is below.
The studies, linked.
2 sources behind our Oroxylum verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
- Clinical trialA Randomized, Double-Blind Placebo Controlled Study to Assess the Effects of an Oroxylum Indicum Extract (Sabroxy™) on Cognitive Function in Adults With Self-reported, Mild Cognitive ImpairmentxClinicalTrials.gov ↗NA · 70 participants · Completed
- Clinical trialAn 8-week Study Evaluating the Effects of a Dietary Supplement (Sabroxy®) on Insulin Resistance and Cognitive Function in Subjects With Mild Cognitive Impairment and Insulin ResistanceClinicalTrials.gov ↗NA · 140 participants · Recruiting
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.
