Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Poke has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Pokeweed greens carry oxalate and triterpenoid saponins, both of which bind divalent minerals in the gut. Traditional preparation boils the shoots in several changes of water, which leaches much of this out along with the irritant fraction. Eating them alongside an iron supplement lowers how much of that iron is taken up.
Oxalate binds calcium into an insoluble salt in the gut, which is the same reason spinach calcium is poorly available. Poke greens sit in that same category of high-oxalate leaves. Anyone with a history of oxalate kidney stones should not be eating them at all.
Poke root and berry are strongly purgative, and anything that speeds transit shortens the window in which other nutrients and medicines are absorbed. Layering a bulk laxative on top compounds that. This is a caution about the combination rather than a benefit.
Repeated vomiting or watery stool strips potassium and sodium. Poke root causes both at doses that are not far above the traditional ones. The relevant point is not that potassium pairs well with poke, it is that poke creates the deficit in the first place, which is one of the reasons the root is not used as a supplement.
Nothing specific on file for Poke. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.2 sources behind our Poke verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.